Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              21     175
XP_005262424                                                           21     175
NP_067048                                                              17    3301
NP_061141                                                              17    3301
XP_005255020                                                           17    3301
NP_001034764                                                           17    3301
NP_004632                                                              17    4312
NP_001182555                                                           17    4312
NP_005952                                                              17    4312
XP_006725823                                                           17    4312
XP_005252668                                                           17    4312
XP_006717572                                                           17    4312
XP_005252667                                                           17    4312
XP_005252666                                                           17    4312
XP_005252665                                                           17    4312
XP_005252663                                                           17    4312
XP_005252662                                                           17    4312
NP_001273632                                                           16    5631
NP_001273635                                                           16    5631
NP_057701                                                              16    5631
NP_001273634                                                           16    5631
NP_065684                                                              16    5631
NP_061855                                                              16    5631
NP_997204                                                              16    5631
NP_005474                                                              16    7355
NP_060626                                                              16    7355
NP_056193                                                              16    7355
NP_002829                                                              16    7355
NP_055430                                                              16    7355
NP_055316                                                              16    7355
NP_005867                                                              16    7355
XP_006721236                                                           16    7355
XP_006721235                                                           16    7355
XP_005255921                                                           16    7355
XP_005255920                                                           16    7355
XP_005255919                                                           16    7355
XP_005255917                                                           16    7355
XP_005255916                                                           16    7355
XP_006712257                                                           16    7355
XP_006712255                                                           16    7355
XP_005246295                                                           16    7355
XP_006712253                                                           16    7355
XP_006712252                                                           16    7355
XP_005246294                                                           16    7355
XP_006712251                                                           16    7355
XP_005246293                                                           16    7355
XP_005246292                                                           16    7355
XP_006712250                                                           16    7355
XP_006711538                                                           16    7355
XP_006711536                                                           16    7355
NP_006302                                                              15    9605
NP_001265430                                                           15    9605
NP_001164433                                                           15    9605
NP_001546                                                              15    9605
NP_001164432                                                           15    9605
NP_001265431                                                           15    9605
XP_006724819                                                           15    9605
XP_006724818                                                           15    9605
XP_005256932                                                           15    9605
XP_006721667                                                           15    9605
XP_005256931                                                           15    9605
XP_005256930                                                           15    9605
XP_006721666                                                           15    9605
XP_005256929                                                           15    9605
XP_005256928                                                           15    9605
XP_006721665                                                           15    9605
XP_005256925                                                           15    9605
XP_005256924                                                           15    9605
XP_006721664                                                           15    9605
XP_005256923                                                           15    9605
XP_006710300                                                           15    9605
>NP_722576
          Length = 3080

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTTITANPR 9
            +TTITANPR
Sbjct: 2110 RTTITANPR 2118
>XP_005262424
          Length = 2875

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTTITANPR 9
            +TTITANPR
Sbjct: 1905 RTTITANPR 1913
>NP_067048
          Length = 248

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTITANP 8
           TTIT NP
Sbjct: 151 TTITTNP 157
>NP_061141
          Length = 944

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K TIT+NP
Sbjct: 714 KLTITSNP 721
>XP_005255020
          Length = 799

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K TIT+NP
Sbjct: 569 KLTITSNP 576
>NP_001034764
          Length = 929

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K TIT+NP
Sbjct: 699 KLTITSNP 706
>NP_004632
          Length = 1027

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 800 TITANP 805
>NP_001182555
          Length = 1068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 784 TITANP 789
>NP_005952
          Length = 2439

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    TTITANP 8
            TTIT NP
Sbjct: 1543 TTITPNP 1549
>XP_006725823
          Length = 1825

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    TTITANP 8
            TTIT NP
Sbjct: 1543 TTITPNP 1549
>XP_005252668
          Length = 839

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 555 TITANP 560
>XP_006717572
          Length = 1003

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 800 TITANP 805
>XP_005252667
          Length = 1052

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 768 TITANP 773
>XP_005252666
          Length = 1057

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 773 TITANP 778
>XP_005252665
          Length = 1068

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 784 TITANP 789
>XP_005252663
          Length = 1084

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 800 TITANP 805
>XP_005252662
          Length = 1084

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TITANP 8
           TITANP
Sbjct: 800 TITANP 805
>NP_001273632
          Length = 83

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTTITANPR 9
          K T+T++PR
Sbjct: 7  KITLTSDPR 15
>NP_001273635
          Length = 71

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTTITANPR 9
          K T+T++PR
Sbjct: 7  KITLTSDPR 15
>NP_057701
          Length = 85

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTTITANPR 9
          K T+T++PR
Sbjct: 7  KITLTSDPR 15
>NP_001273634
          Length = 71

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTTITANPR 9
          K T+T++PR
Sbjct: 7  KITLTSDPR 15
>NP_065684
          Length = 353

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TTITANP 8
           TT+ ANP
Sbjct: 296 TTVVANP 302
>NP_061855
          Length = 306

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TTITANP 8
          T++TANP
Sbjct: 17 TSLTANP 23
>NP_997204
          Length = 480

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   TTITANP 8
           TT++ANP
Sbjct: 312 TTLSANP 318
>NP_005474
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K T+TA+P
Sbjct: 945 KATLTASP 952
>NP_060626
          Length = 4363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KTTITANPR 9
            KTT T  PR
Sbjct: 2090 KTTSTEEPR 2098
>NP_056193
          Length = 4388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KTTITANPR 9
            KTT T  PR
Sbjct: 2090 KTTSTEEPR 2098
>NP_002829
          Length = 1306

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTITAN 7
           TTITAN
Sbjct: 187 TTITAN 192
>NP_055430
          Length = 1217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTTITANP 8
          +TT T NP
Sbjct: 21 RTTATVNP 28
>NP_055316
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  TTITANP 8
          TT+TA+P
Sbjct: 21 TTLTADP 27
>NP_005867
          Length = 3267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 742 KCIITANP 749
>XP_006721236
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTTITANP 8
          +TT T NP
Sbjct: 18 RTTATVNP 25
>XP_006721235
          Length = 1214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTTITANP 8
          +TT T NP
Sbjct: 18 RTTATVNP 25
>XP_005255921
          Length = 1227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTTITANP 8
          +TT T NP
Sbjct: 31 RTTATVNP 38
>XP_005255920
          Length = 1229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTTITANP 8
          +TT T NP
Sbjct: 33 RTTATVNP 40
>XP_005255919
          Length = 1860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           +TT T NP
Sbjct: 826 RTTATVNP 833
>XP_005255917
          Length = 1984

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           +TT T NP
Sbjct: 826 RTTATVNP 833
>XP_005255916
          Length = 2022

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           +TT T NP
Sbjct: 826 RTTATVNP 833
>XP_006712257
          Length = 1718

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 742 KCIITANP 749
>XP_006712255
          Length = 2622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 742 KCIITANP 749
>XP_005246295
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 589 KCIITANP 596
>XP_006712253
          Length = 3117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 592 KCIITANP 599
>XP_006712252
          Length = 3163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 638 KCIITANP 645
>XP_005246294
          Length = 3173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 648 KCIITANP 655
>XP_006712251
          Length = 3176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 651 KCIITANP 658
>XP_005246293
          Length = 3206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 742 KCIITANP 749
>XP_005246292
          Length = 3208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 683 KCIITANP 690
>XP_006712250
          Length = 3248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KTTITANP 8
           K  ITANP
Sbjct: 723 KCIITANP 730
>XP_006711538
          Length = 1189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TTITAN 7
          TTITAN
Sbjct: 70 TTITAN 75
>XP_006711536
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TTITAN 7
           TTITAN
Sbjct: 121 TTITAN 126
>NP_006302
          Length = 2440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1924 KTTITA 1929
>NP_001265430
          Length = 126

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTTITANPR 9
          K+T +A+PR
Sbjct: 23 KSTASASPR 31
>NP_001164433
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K T+TA+P
Sbjct: 218 KPTLTAHP 225
>NP_001546
          Length = 1336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K T+TA+P
Sbjct: 227 KPTLTAHP 234
>NP_001164432
          Length = 1341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K T+TA+P
Sbjct: 227 KPTLTAHP 234
>NP_001265431
          Length = 71

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTTITANPR 9
          K+T +A+PR
Sbjct: 23 KSTASASPR 31
>XP_006724819
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K T+TA+P
Sbjct: 227 KPTLTAHP 234
>XP_006724818
          Length = 1304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTTITANP 8
           K T+TA+P
Sbjct: 227 KPTLTAHP 234
>XP_005256932
          Length = 2448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1932 KTTITA 1937
>XP_006721667
          Length = 2456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1940 KTTITA 1945
>XP_005256931
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1950 KTTITA 1955
>XP_005256930
          Length = 2508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1992 KTTITA 1997
>XP_006721666
          Length = 2511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_005256929
          Length = 2514

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1998 KTTITA 2003
>XP_005256928
          Length = 2515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 1999 KTTITA 2004
>XP_006721665
          Length = 2523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 2007 KTTITA 2012
>XP_005256925
          Length = 2523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 2007 KTTITA 2012
>XP_005256924
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_006721664
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_005256923
          Length = 2524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KTTITA 6
            KTTITA
Sbjct: 2008 KTTITA 2013
>XP_006710300
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KTTITANPR 9
           KTT+ + PR
Sbjct: 733 KTTLHSTPR 741
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.116    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 559,023
Number of extensions: 938
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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