Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_036462                                                              20     509
NP_001243397                                                           20     509
XP_005269721                                                           20     509
NP_001033794                                                           18    1935
NP_001129245                                                           17    4312
NP_006029                                                              17    4312
XP_006723957                                                           17    4312
NP_055935                                                              16    5631
NP_001185744                                                           16    5631
NP_057510                                                              16    5631
XP_005275558                                                           16    5631
XP_005275391                                                           16    5631
XP_005275259                                                           16    5631
XP_005274965                                                           16    5631
XP_005272815                                                           16    5631
XP_006725506                                                           16    5631
XP_005274885                                                           16    5631
XP_005261684                                                           16    5631
XP_005248836                                                           16    5631
NP_001277155                                                           16    7355
NP_001277156                                                           16    7355
NP_055998                                                              16    7355
NP_078887                                                              16    7355
NP_001158136                                                           16    7355
NP_001018099                                                           16    7355
NP_004952                                                              16    7355
NP_061897                                                              16    7355
XP_006724876                                                           16    7355
XP_006724875                                                           16    7355
XP_005254720                                                           16    7355
XP_005254719                                                           16    7355
XP_005254718                                                           16    7355
XP_006714675                                                           16    7355
XP_006714673                                                           16    7355
XP_006714672                                                           16    7355
XP_006714670                                                           16    7355
XP_006714669                                                           16    7355
XP_006714668                                                           16    7355
XP_006714667                                                           16    7355
XP_006714666                                                           16    7355
XP_005248555                                                           16    7355
XP_006714665                                                           16    7355
XP_005264436                                                           16    7355
XP_006712098                                                           16    7355
XP_006712097                                                           16    7355
NP_078966                                                              15    9605
NP_003453                                                              15    9605
NP_001032                                                              15    9605
NP_004997                                                              15    9605
NP_296374                                                              15    9605
NP_115565                                                              15    9605
NP_000986                                                              15    9605
NP_005119                                                              15    9605
NP_003133                                                              15    9605
NP_001186913                                                           15    9605
XP_006724131                                                           15    9605
XP_005268357                                                           15    9605
XP_005268356                                                           15    9605
XP_006714350                                                           15    9605
XP_005263229                                                           15    9605
XP_005264824                                                           15    9605
XP_005246868                                                           15    9605
NP_001186911                                                           15    9605
NP_001186910                                                           15    9605
NP_001186912                                                           15    9605
NP_938012                                                              15    9605
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           KTKV TTPS
Sbjct: 377 KTKVCTTPS 385
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           KTKV TTPS
Sbjct: 377 KTKVCTTPS 385
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           KTKV TTPS
Sbjct: 377 KTKVCTTPS 385
>NP_001033794
          Length = 731

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           K ++STTPS
Sbjct: 453 KVEISTTPS 461
>NP_001129245
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           K+K STTP+
Sbjct: 449 KSKPSTTPT 457
>NP_006029
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           K+K STTP+
Sbjct: 449 KSKPSTTPT 457
>XP_006723957
          Length = 520

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KTKVSTTPS 9
           K+K STTP+
Sbjct: 449 KSKPSTTPT 457
>NP_055935
          Length = 4169

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TKVSTTP 8
           TKVS TP
Sbjct: 742 TKVSATP 748
>NP_001185744
          Length = 1773

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 206 TKVSTTGS 213

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 955 TKVSTTGS 962
>NP_057510
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTKV  TP+
Sbjct: 459 KTKVMPTPT 467
>XP_005275558
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>XP_005275391
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>XP_005275259
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>XP_005274965
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>XP_005272815
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>XP_006725506
          Length = 250

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           +TK ST PS
Sbjct: 221 ETKTSTRPS 229
>XP_005274885
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>XP_005261684
          Length = 739

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTKV  TP+
Sbjct: 459 KTKVMPTPT 467
>XP_005248836
          Length = 1776

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 209 TKVSTTGS 216

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVSTT S
Sbjct: 958 TKVSTTGS 965
>NP_001277155
          Length = 2417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 726 KTKSTTLPS 734
>NP_001277156
          Length = 2362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 738 KTKSTTLPS 746
>NP_055998
          Length = 2434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 743 KTKSTTLPS 751
>NP_078887
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVS +PS
Sbjct: 411 TKVSKSPS 418
>NP_001158136
          Length = 2623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 932 KTKSTTLPS 940
>NP_001018099
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVS +PS
Sbjct: 274 TKVSKSPS 281
>NP_004952
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           KT++ TTP
Sbjct: 253 KTEIITTP 260
>NP_061897
          Length = 2071

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TKVSTTPS 9
            TKVS +PS
Sbjct: 1732 TKVSDSPS 1739
>XP_006724876
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           KT++ TTP
Sbjct: 140 KTEIITTP 147
>XP_006724875
          Length = 313

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTKVSTTP 8
          KT++ TTP
Sbjct: 60 KTEIITTP 67
>XP_005254720
          Length = 772

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVS +PS
Sbjct: 411 TKVSKSPS 418
>XP_005254719
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVS +PS
Sbjct: 274 TKVSKSPS 281
>XP_005254718
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TKVSTTPS 9
           TKVS +PS
Sbjct: 411 TKVSKSPS 418
>XP_006714675
          Length = 2275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 584 KTKSTTLPS 592
>XP_006714673
          Length = 2362

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 738 KTKSTTLPS 746
>XP_006714672
          Length = 2414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 723 KTKSTTLPS 731
>XP_006714670
          Length = 2425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 734 KTKSTTLPS 742
>XP_006714669
          Length = 2429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 738 KTKSTTLPS 746
>XP_006714668
          Length = 2429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 738 KTKSTTLPS 746
>XP_006714667
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 741 KTKSTTLPS 749
>XP_006714666
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 741 KTKSTTLPS 749
>XP_005248555
          Length = 2626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 935 KTKSTTLPS 943
>XP_006714665
          Length = 2651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK +T PS
Sbjct: 960 KTKSTTLPS 968
>XP_005264436
          Length = 1881

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TKVSTTPS 9
            TKVS +PS
Sbjct: 1732 TKVSDSPS 1739
>XP_006712098
          Length = 2059

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TKVSTTPS 9
            TKVS +PS
Sbjct: 1720 TKVSDSPS 1727
>XP_006712097
          Length = 2070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TKVSTTPS 9
            TKVS +PS
Sbjct: 1732 TKVSDSPS 1739
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    TKVSTTPS 9
            T VST PS
Sbjct: 4367 TDVSTNPS 4374
>NP_003453
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTKVSTTP 8
          KTK+ +TP
Sbjct: 71 KTKLPSTP 78
>NP_001032
          Length = 1827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  TKVSTTPS 9
          T+V+T PS
Sbjct: 51 TRVTTNPS 58
>NP_004997
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           +TKV+ TP
Sbjct: 605 QTKVAVTP 612
>NP_296374
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTKVSTTP 8
          KT++S TP
Sbjct: 19 KTRLSRTP 26
>NP_115565
          Length = 1191

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    KTKVSTTP 8
            K KVST P
Sbjct: 1156 KEKVSTEP 1163
>NP_000986
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTKVSTTP 8
          KT++S TP
Sbjct: 19 KTRLSRTP 26
>NP_005119
          Length = 2298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK S +PS
Sbjct: 708 KTKSSESPS 716
>NP_003133
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KTKVSTTPS 9
          KTK+  +PS
Sbjct: 86 KTKIRRSPS 94
>NP_001186913
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           +TKV+ TP
Sbjct: 619 QTKVAVTP 626
>XP_006724131
          Length = 2298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTKVSTTPS 9
           KTK S +PS
Sbjct: 708 KTKSSESPS 716
>XP_005268357
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    KTKVSTTP 8
            K KVST P
Sbjct: 1136 KEKVSTEP 1143
>XP_005268356
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    KTKVSTTP 8
            K KVST P
Sbjct: 1157 KEKVSTEP 1164
>XP_006714350
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTKVSTTP 8
          KT++S TP
Sbjct: 19 KTRLSRTP 26
>XP_005263229
          Length = 117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTKVSTTP 8
          KT++S TP
Sbjct: 19 KTRLSRTP 26
>XP_005264824
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KVSTTPS 9
           KVST PS
Sbjct: 229 KVSTRPS 235
>XP_005246868
          Length = 408

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KTKVSTTPS 9
          KTK+  +PS
Sbjct: 86 KTKIRRSPS 94
>NP_001186911
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           +TKV+ TP
Sbjct: 494 QTKVAVTP 501
>NP_001186910
          Length = 691

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           +TKV+ TP
Sbjct: 569 QTKVAVTP 576
>NP_001186912
          Length = 670

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KTKVSTTP 8
           +TKV+ TP
Sbjct: 548 QTKVAVTP 555
>NP_938012
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   KVSTTPS 9
           KVST PS
Sbjct: 229 KVSTRPS 235
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.284   0.0972    0.237 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 677,738
Number of extensions: 1042
Number of successful extensions: 74
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 18 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.8 bits)
S2: 28 (15.4 bits)

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