Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005091                                                              21     229
NP_653080                                                              21     229
XP_005267292                                                           21     229
XP_005267291                                                           21     229
XP_005267290                                                           21     229
NP_055904                                                              18    1135
XP_006715095                                                           18    1135
XP_006715094                                                           18    1135
XP_006715093                                                           18    1135
XP_006715092                                                           18    1135
NP_001176                                                              18    1482
NP_005834                                                              17    3301
NP_000825                                                              17    4312
NP_996816                                                              17    4312
NP_004637                                                              17    4312
XP_005259018                                                           17    4312
NP_001153648                                                           16    5631
NP_001153647                                                           16    5631
NP_115543                                                              16    5631
XP_005255740                                                           16    5631
XP_005255739                                                           16    5631
NP_001175                                                              16    7355
NP_001094343                                                           16    7355
NP_689550                                                              16    7355
NP_001229725                                                           16    7355
NP_001229724                                                           16    7355
NP_689472                                                              16    7355
NP_055484                                                              16    7355
XP_006723231                                                           16    7355
XP_005258877                                                           16    7355
XP_005258876                                                           16    7355
XP_005256320                                                           16    7355
XP_005255849                                                           16    7355
XP_005255848                                                           16    7355
NP_054756                                                              16    7355
NP_057434                                                              15    9605
NP_062550                                                              15    9605
NP_891989                                                              15    9605
NP_065972                                                              15    9605
NP_001136241                                                           15    9605
NP_891991                                                              15    9605
NP_001019626                                                           15    9605
NP_116269                                                              15    9605
NP_037402                                                              15    9605
NP_006718                                                              15    9605
NP_001008781                                                           15    9605
NP_001008392                                                           15    9605
XP_006720224                                                           15    9605
XP_005267794                                                           15    9605
XP_005267793                                                           15    9605
XP_005267792                                                           15    9605
XP_006720223                                                           15    9605
XP_006718013                                                           15    9605
XP_005248564                                                           15    9605
NP_005900                                                              15    9605
NP_068598                                                              15    9605
>NP_005091
          Length = 1782

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTEAEPTYV 9
            KTEAEPT+V
Sbjct: 1345 KTEAEPTHV 1353
>NP_653080
          Length = 1684

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTEAEPTYV 9
            KTEAEPT+V
Sbjct: 1247 KTEAEPTHV 1255
>XP_005267292
          Length = 1677

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTEAEPTYV 9
            KTEAEPT+V
Sbjct: 1240 KTEAEPTHV 1248
>XP_005267291
          Length = 1684

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTEAEPTYV 9
            KTEAEPT+V
Sbjct: 1247 KTEAEPTHV 1255
>XP_005267290
          Length = 1782

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KTEAEPTYV 9
            KTEAEPT+V
Sbjct: 1345 KTEAEPTHV 1353
>NP_055904
          Length = 2517

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTEAEPT 7
           KTEAEPT
Sbjct: 620 KTEAEPT 626
>XP_006715095
          Length = 2046

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTEAEPT 7
           KTEAEPT
Sbjct: 149 KTEAEPT 155
>XP_006715094
          Length = 2407

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTEAEPT 7
           KTEAEPT
Sbjct: 510 KTEAEPT 516
>XP_006715093
          Length = 2459

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTEAEPT 7
           KTEAEPT
Sbjct: 562 KTEAEPT 568
>XP_006715092
          Length = 2490

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KTEAEPT 7
           KTEAEPT
Sbjct: 620 KTEAEPT 626
>NP_001176
          Length = 298

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KTEAEPTYV 9
           K EAEP YV
Sbjct: 167 KWEAEPVYV 175
>NP_005834
          Length = 525

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KTEAEPTYV 9
           K+E EP Y+
Sbjct: 284 KSEPEPVYI 292
>NP_000825
          Length = 1484

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KTEAEPTYV 9
           KT+ EP Y+
Sbjct: 445 KTDEEPGYI 453
>NP_996816
          Length = 5202

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    TEAEPTYV 9
            TE+ PTYV
Sbjct: 2807 TESLPTYV 2814
>NP_004637
          Length = 1241

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    TEAEPTY 8
            TEAEP Y
Sbjct: 1133 TEAEPYY 1139
>XP_005259018
          Length = 1128

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2    TEAEPTY 8
            TEAEP Y
Sbjct: 1020 TEAEPYY 1026
>NP_001153648
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTEAEPTY 8
          KTE +PT+
Sbjct: 48 KTEDQPTF 55
>NP_001153647
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KTEAEPTY 8
          KTE +PT+
Sbjct: 48 KTEDQPTF 55
>NP_115543
          Length = 813

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTEAEPTY 8
          KTE EP +
Sbjct: 79 KTETEPVF 86
>XP_005255740
          Length = 551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTEAEPTY 8
          KTE EP +
Sbjct: 89 KTETEPVF 96
>XP_005255739
          Length = 823

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  KTEAEPTY 8
          KTE EP +
Sbjct: 89 KTETEPVF 96
>NP_001175
          Length = 2644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KTEAEPTYV 9
          KT+++PT V
Sbjct: 58 KTDSQPTSV 66
>NP_001094343
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  EAEPTY 8
          E EPTY
Sbjct: 24 ETEPTY 29
>NP_689550
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  EAEPTY 8
          E EPTY
Sbjct: 24 ETEPTY 29
>NP_001229725
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  EAEPTYV 9
          E+EP+Y+
Sbjct: 38 ESEPSYI 44
>NP_001229724
          Length = 696

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  EAEPTYV 9
          E+EP+Y+
Sbjct: 38 ESEPSYI 44
>NP_689472
          Length = 1910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    TEAEPTYV 9
            ++ EPTYV
Sbjct: 1615 SKPEPTYV 1622
>NP_055484
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   EAEPTYV 9
           E+EP+Y+
Sbjct: 161 ESEPSYI 167
>XP_006723231
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KTEAEPT 7
         KTEA+P+
Sbjct: 2 KTEAQPS 8
>XP_005258877
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KTEAEPT 7
         KTEA+P+
Sbjct: 2 KTEAQPS 8
>XP_005258876
          Length = 818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  KTEAEPT 7
          KTEA+P+
Sbjct: 84 KTEAQPS 90
>XP_005256320
          Length = 819

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   EAEPTYV 9
           E+EP+Y+
Sbjct: 161 ESEPSYI 167
>XP_005255849
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  EAEPTY 8
          E EPTY
Sbjct: 24 ETEPTY 29
>XP_005255848
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  EAEPTY 8
          E EPTY
Sbjct: 24 ETEPTY 29
>NP_054756
          Length = 736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1 KTEAEPT 7
         KTEA+P+
Sbjct: 2 KTEAQPS 8
>NP_057434
          Length = 1377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>NP_062550
          Length = 393

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TEAEPTYV 9
           TEA P Y+
Sbjct: 272 TEANPQYL 279
>NP_891989
          Length = 2046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>NP_065972
          Length = 2133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>NP_001136241
          Length = 1790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    AEPTY 8
            AEPTY
Sbjct: 1538 AEPTY 1542
>NP_891991
          Length = 2090

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>NP_001019626
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   EAEPTYV 9
           E EPT+V
Sbjct: 469 EMEPTFV 475
>NP_116269
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   AEPTY 8
           AEPTY
Sbjct: 281 AEPTY 285
>NP_037402
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KTEAEPTYV 9
           K+EA P Y+
Sbjct: 336 KSEAPPIYL 344
>NP_006718
          Length = 788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KTEAEPTYV 9
           K EAE T+V
Sbjct: 347 KVEAENTHV 355
>NP_001008781
          Length = 4557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3   EAEPTY 8
           E EPTY
Sbjct: 277 EKEPTY 282
>NP_001008392
          Length = 1079

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KTEAEPTYV 9
           KTE  P Y+
Sbjct: 894 KTEKTPVYM 902
>XP_006720224
          Length = 1276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>XP_005267794
          Length = 1379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>XP_005267793
          Length = 1390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>XP_005267792
          Length = 1420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>XP_006720223
          Length = 1989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  EAEPTYV 9
          EA+P YV
Sbjct: 93 EAQPKYV 99
>XP_006718013
          Length = 1778

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4    AEPTY 8
            AEPTY
Sbjct: 1526 AEPTY 1530
>XP_005248564
          Length = 2342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    KTEAEPTYV 9
            KTE  P+++
Sbjct: 1968 KTELSPSFI 1976
>NP_005900
          Length = 2468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    KTEAEPTYV 9
            KTE  P+++
Sbjct: 2094 KTELSPSFI 2102
>NP_068598
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KTEAEP 6
           KTE+EP
Sbjct: 645 KTESEP 650
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.296    0.116    0.309 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 842,178
Number of extensions: 1383
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package