Blast-Search of mutated query peptide against human proteome |
BLASTP 2.2.15 [Oct-15-2006] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= User_input (9 letters) Database: HUMAN_PROTEOME_FASTA 71,491 sequences; 45,948,801 total letters Searching..................................................doneScore E Sequences producing significant alignments: (bits) Value NP_006197 20 509 XP_006714104 20 509 XP_005265800 20 509 XP_006714103 20 509 XP_006714102 20 509 NP_055483 16 5631 NP_877949 16 5631 NP_000924 16 5631 NP_001166117 16 5631 NP_733828 16 5631 NP_851782 16 5631 XP_006723635 16 5631 XP_006723634 16 5631 XP_006723633 16 5631 XP_005260781 16 5631 XP_006723632 16 5631 XP_006723631 16 5631 XP_005262782 16 5631 XP_006714141 16 5631 XP_005262780 16 5631 XP_005262779 16 5631 XP_006711971 16 5631 XP_005246252 16 5631 XP_006711970 16 5631 XP_006711969 16 5631 XP_005246249 16 5631 XP_006711968 16 5631 XP_006711967 16 5631 NP_612455 16 5631 NP_775759 16 7355 NP_001275933 16 7355 NP_001275931 16 7355 NP_001172006 16 7355 NP_004300 16 7355 NP_003673 16 7355 NP_001129416 16 7355 NP_569830 16 7355 NP_569829 16 7355 NP_569828 16 7355 NP_569827 16 7355 NP_569826 16 7355 XP_005253263 16 7355 XP_005253262 16 7355 XP_005253261 16 7355 XP_005253260 16 7355 XP_006718426 16 7355 XP_005253259 16 7355 XP_005253258 16 7355 XP_005253257 16 7355 XP_005253256 16 7355 XP_005253255 16 7355 XP_006718425 16 7355 XP_005253254 16 7355 XP_005253253 16 7355 XP_005253252 16 7355 XP_006718424 16 7355 XP_005253251 16 7355 XP_005253250 16 7355 XP_005253249 16 7355 XP_005253248 16 7355 XP_006718423 16 7355 XP_005253247 16 7355 XP_005253246 16 7355 XP_005253245 16 7355 XP_005271931 16 7355 NP_001129415 16 7355 NP_569831 16 7355 NP_569832 16 7355 NP_006266 15 9605 NP_005617 15 9605 NP_001070962 15 9605 NP_001248332 15 9605 NP_002493 15 9605 NP_001275653 15 9605 NP_001121614 15 9605 NP_001186611 15 9605 NP_001265177 15 9605 NP_001265176 15 9605 NP_003133 15 9605 XP_006717932 15 9605 XP_005269918 15 9605 XP_005269917 15 9605 XP_005246868 15 9605 NP_056300 15 9605>NP_006197 Length = 1089 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 TDYLVIVE 9 TDYLVIVE Sbjct: 134 TDYLVIVE 141>XP_006714104 Length = 832 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 TDYLVIVE 9 TDYLVIVE Sbjct: 159 TDYLVIVE 166>XP_005265800 Length = 1089 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 TDYLVIVE 9 TDYLVIVE Sbjct: 134 TDYLVIVE 141>XP_006714103 Length = 1111 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 TDYLVIVE 9 TDYLVIVE Sbjct: 156 TDYLVIVE 163>XP_006714102 Length = 1114 Score = 19.6 bits (39), Expect = 509 Identities = 8/8 (100%), Positives = 8/8 (100%) Query: 2 TDYLVIVE 9 TDYLVIVE Sbjct: 159 TDYLVIVE 166>NP_055483 Length = 1949 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>NP_877949 Length = 1175 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>NP_000924 Length = 1194 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>NP_001166117 Length = 1187 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>NP_733828 Length = 1322 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 TDYL++V Sbjct: 236 TDYLLVV 242>NP_851782 Length = 1283 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 TDYL++V Sbjct: 212 TDYLLVV 218>XP_006723635 Length = 1175 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>XP_006723634 Length = 1187 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>XP_006723633 Length = 1194 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>XP_005260781 Length = 1206 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>XP_006723632 Length = 1206 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>XP_006723631 Length = 1206 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 6/7 (85%) Query: 1 KTDYLVI 7 KTDYL + Sbjct: 233 KTDYLTV 239>XP_005262782 Length = 1216 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 TDYL++V Sbjct: 138 TDYLLVV 144>XP_006714141 Length = 1259 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 TDYL++V Sbjct: 236 TDYLLVV 242>XP_005262780 Length = 1307 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 TDYL++V Sbjct: 236 TDYLLVV 242>XP_005262779 Length = 1314 Score = 16.2 bits (30), Expect = 5631 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 TDYL++V Sbjct: 236 TDYLLVV 242>XP_006711971 Length = 1517 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>XP_005246252 Length = 1850 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 444 KTNYVVII 451>XP_006711970 Length = 1948 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>XP_006711969 Length = 1949 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>XP_005246249 Length = 1949 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>XP_006711968 Length = 1949 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>XP_006711967 Length = 1949 Score = 16.2 bits (30), Expect = 5631 Identities = 5/8 (62%), Positives = 8/8 (100%) Query: 1 KTDYLVIV 8 KT+Y+VI+ Sbjct: 543 KTNYVVII 550>NP_612455 Length = 234 Score = 16.2 bits (30), Expect = 5631 Identities = 6/7 (85%), Positives = 6/7 (85%) Query: 2 TDYLVIV 8 TDY VIV Sbjct: 121 TDYFVIV 127>NP_775759 Length = 719 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 T+YLVI+ Sbjct: 394 TEYLVII 400>NP_001275933 Length = 657 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 T+YLVI+ Sbjct: 332 TEYLVII 338>NP_001275931 Length = 719 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 T+YLVI+ Sbjct: 394 TEYLVII 400>NP_001172006 Length = 204 Score = 15.8 bits (29), Expect = 7355 Identities = 5/6 (83%), Positives = 6/6 (100%) Query: 1 KTDYLV 6 KTDY+V Sbjct: 141 KTDYMV 146>NP_004300 Length = 204 Score = 15.8 bits (29), Expect = 7355 Identities = 5/6 (83%), Positives = 6/6 (100%) Query: 1 KTDYLV 6 KTDY+V Sbjct: 141 KTDYMV 146>NP_003673 Length = 1647 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_001129416 Length = 1541 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569830 Length = 1479 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569829 Length = 1608 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569828 Length = 1545 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569827 Length = 1565 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569826 Length = 1588 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253263 Length = 1231 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253262 Length = 1479 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253261 Length = 1541 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253260 Length = 1545 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_006718426 Length = 1553 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253259 Length = 1561 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253258 Length = 1565 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253257 Length = 1580 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253256 Length = 1588 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253255 Length = 1591 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_006718425 Length = 1596 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253254 Length = 1607 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253253 Length = 1608 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253252 Length = 1610 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_006718424 Length = 1611 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253251 Length = 1625 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253250 Length = 1628 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253249 Length = 1628 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253248 Length = 1630 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_006718423 Length = 1632 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253247 Length = 1646 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253246 Length = 1647 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005253245 Length = 1649 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>XP_005271931 Length = 719 Score = 15.8 bits (29), Expect = 7355 Identities = 5/7 (71%), Positives = 7/7 (100%) Query: 2 TDYLVIV 8 T+YLVI+ Sbjct: 394 TEYLVII 400>NP_001129415 Length = 1544 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569831 Length = 1581 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_569832 Length = 1587 Score = 15.8 bits (29), Expect = 7355 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 3 DYLVIV 8 DYLVIV Sbjct: 13 DYLVIV 18>NP_006266 Length = 344 Score = 15.4 bits (28), Expect = 9605 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 KTDYLVIVE 9 +T+Y +IVE Sbjct: 107 RTEYRLIVE 115>NP_005617 Length = 494 Score = 15.4 bits (28), Expect = 9605 Identities = 5/9 (55%), Positives = 8/9 (88%) Query: 1 KTDYLVIVE 9 +T+Y +IVE Sbjct: 101 RTEYRLIVE 109>NP_001070962 Length = 900 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>NP_001248332 Length = 899 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>NP_002493 Length = 899 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>NP_001275653 Length = 899 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>NP_001121614 Length = 195 Score = 15.4 bits (28), Expect = 9605 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 KTDYLVIVE 9 KT Y+ IVE Sbjct: 152 KTKYVKIVE 160>NP_001186611 Length = 200 Score = 15.4 bits (28), Expect = 9605 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 KTDYLVIVE 9 KT Y+ IVE Sbjct: 152 KTKYVKIVE 160>NP_001265177 Length = 252 Score = 15.4 bits (28), Expect = 9605 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 KTDYLVIVE 9 KT Y+ IVE Sbjct: 137 KTKYVKIVE 145>NP_001265176 Length = 185 Score = 15.4 bits (28), Expect = 9605 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 KTDYLVIVE 9 KT Y+ IVE Sbjct: 137 KTKYVKIVE 145>NP_003133 Length = 408 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 TDYLVIVE 9 TD+ VIVE Sbjct: 63 TDFNVIVE 70>XP_006717932 Length = 858 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>XP_005269918 Length = 900 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>XP_005269917 Length = 900 Score = 15.4 bits (28), Expect = 9605 Identities = 6/6 (100%), Positives = 6/6 (100%) Query: 4 YLVIVE 9 YLVIVE Sbjct: 39 YLVIVE 44>XP_005246868 Length = 408 Score = 15.4 bits (28), Expect = 9605 Identities = 6/8 (75%), Positives = 7/8 (87%) Query: 2 TDYLVIVE 9 TD+ VIVE Sbjct: 63 TDFNVIVE 70>NP_056300 Length = 267 Score = 15.4 bits (28), Expect = 9605 Identities = 6/9 (66%), Positives = 7/9 (77%) Query: 1 KTDYLVIVE 9 KT Y+ IVE Sbjct: 152 KTKYVKIVE 160Database: HUMAN_PROTEOME_FASTA Posted date: May 26, 2014 10:46 AM Number of letters in database: 45,948,801 Number of sequences in database: 71,491 Lambda K H 0.320 0.142 0.371 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 71491 Number of Hits to DB: 477,617 Number of extensions: 833 Number of successful extensions: 84 Number of sequences better than 10000.0: 84 Number of HSP's gapped: 84 Number of HSP's successfully gapped: 84 Length of query: 9 Length of database: 45,948,801 Length adjustment: 0 Effective length of query: 9 Effective length of database: 45,948,801 Effective search space: 413539209 Effective search space used: 413539209 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 28 (15.7 bits) S2: 28 (15.4 bits)
CANCERTOPE | Raghava's Group | IMTECH | CSIR | CRDD | GPSR Package |