Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              20     390
XP_005273257                                                           20     390
XP_005251977                                                           16    5631
NP_001004451                                                           16    5631
NP_473448                                                              16    5631
NP_001258747                                                           16    7355
NP_001258748                                                           16    7355
NP_001119812                                                           16    7355
NP_004220                                                              16    7355
NP_056364                                                              16    7355
NP_116220                                                              16    7355
XP_005272757                                                           16    7355
XP_005272756                                                           16    7355
XP_005267570                                                           16    7355
XP_006720171                                                           16    7355
XP_005267569                                                           16    7355
XP_005267568                                                           16    7355
XP_006720170                                                           16    7355
XP_006720169                                                           16    7355
NP_056130                                                              15    9605
NP_001275918                                                           15    9605
NP_001159451                                                           15    9605
NP_001026868                                                           15    9605
NP_004216                                                              15    9605
NP_777360                                                              15    9605
NP_057425                                                              15    9605
NP_219479                                                              15    9605
NP_002807                                                              15    9605
XP_006719964                                                           15    9605
XP_006719963                                                           15    9605
XP_006719962                                                           15    9605
XP_006719961                                                           15    9605
XP_006719960                                                           15    9605
XP_005266656                                                           15    9605
XP_006719393                                                           15    9605
XP_006719392                                                           15    9605
XP_006719391                                                           15    9605
XP_006719390                                                           15    9605
XP_006719389                                                           15    9605
XP_006719388                                                           15    9605
XP_006719387                                                           15    9605
XP_006717953                                                           15    9605
XP_006717952                                                           15    9605
XP_006717951                                                           15    9605
XP_006717950                                                           15    9605
XP_006717949                                                           15    9605
XP_006717948                                                           15    9605
XP_005248705                                                           15    9605
XP_006715387                                                           15    9605
XP_006715386                                                           15    9605
XP_006714838                                                           15    9605
XP_005268463                                                           15    9605
XP_005268461                                                           15    9605
NP_004285                                                              15    9605
>NP_064450
          Length = 1722

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SVQLDSHQ 9
           SVQLDSHQ
Sbjct: 795 SVQLDSHQ 802
>XP_005273257
          Length = 1726

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   SVQLDSHQ 9
           SVQLDSHQ
Sbjct: 799 SVQLDSHQ 806
>XP_005251977
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VQLDSH 8
          +QLDSH
Sbjct: 49 IQLDSH 54
>NP_001004451
          Length = 322

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VQLDSH 8
          +QLDSH
Sbjct: 49 IQLDSH 54
>NP_473448
          Length = 313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  VQLDSH 8
          +QLDSH
Sbjct: 49 IQLDSH 54
>NP_001258747
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VQLDSHQ 9
           VQLD H+
Sbjct: 242 VQLDGHE 248
>NP_001258748
          Length = 177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VQLDSHQ 9
           VQLD H+
Sbjct: 165 VQLDGHE 171
>NP_001119812
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VQLDSHQ 9
           VQLD H+
Sbjct: 242 VQLDGHE 248
>NP_004220
          Length = 1454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VQLDSHQ 9
          VQL++HQ
Sbjct: 4  VQLENHQ 10
>NP_056364
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 488 QLDAHQ 493
>NP_116220
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   VQLDSHQ 9
           VQLD H+
Sbjct: 242 VQLDGHE 248
>XP_005272757
          Length = 1410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VQLDSHQ 9
          VQL++HQ
Sbjct: 4  VQLENHQ 10
>XP_005272756
          Length = 1443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VQLDSHQ 9
          VQL++HQ
Sbjct: 4  VQLENHQ 10
>XP_005267570
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 544 QLDAHQ 549
>XP_006720171
          Length = 1240

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 565 QLDAHQ 570
>XP_005267569
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 665 QLDAHQ 670
>XP_005267568
          Length = 1340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 665 QLDAHQ 670
>XP_006720170
          Length = 1354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 679 QLDAHQ 684
>XP_006720169
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   QLDSHQ 9
           QLD+HQ
Sbjct: 686 QLDAHQ 691
>NP_056130
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSVQLDSHQ 9
           KSVQ  SH+
Sbjct: 108 KSVQPQSHK 116
>NP_001275918
          Length = 2286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>NP_001159451
          Length = 1994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 544 SIQADVHQ 551
>NP_001026868
          Length = 892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 887 QLDDHQ 892
>NP_004216
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   SVQLDSH 8
           SVQ++SH
Sbjct: 899 SVQINSH 905
>NP_777360
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   VQLDSHQ 9
           +QLD H+
Sbjct: 211 IQLDQHE 217
>NP_057425
          Length = 2302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>NP_219479
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KSVQLDSHQ 9
          +S +LD HQ
Sbjct: 90 RSSELDRHQ 98
>NP_002807
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   VQLDSHQ 9
           +QLD H+
Sbjct: 231 IQLDQHE 237
>XP_006719964
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
>XP_006719963
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
>XP_006719962
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
>XP_006719961
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
>XP_006719960
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
>XP_005266656
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
>XP_006719393
          Length = 866

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 861 QLDDHQ 866
>XP_006719392
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 869 QLDDHQ 874
>XP_006719391
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 888 QLDDHQ 893
>XP_006719390
          Length = 900

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 895 QLDDHQ 900
>XP_006719389
          Length = 901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 896 QLDDHQ 901
>XP_006719388
          Length = 954

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 949 QLDDHQ 954
>XP_006719387
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   QLDSHQ 9
           QLD HQ
Sbjct: 950 QLDDHQ 955
>XP_006717953
          Length = 2008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 544 SIQADVHQ 551
>XP_006717952
          Length = 2300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>XP_006717951
          Length = 2315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>XP_006717950
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>XP_006717949
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>XP_006717948
          Length = 2316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   SVQLDSHQ 9
           S+Q D HQ
Sbjct: 852 SIQADVHQ 859
>XP_005248705
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KSVQLDSHQ 9
          +S +LD HQ
Sbjct: 15 RSSELDRHQ 23
>XP_006715387
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KSVQLDSHQ 9
          +S +LD HQ
Sbjct: 24 RSSELDRHQ 32
>XP_006715386
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KSVQLDSHQ 9
          +S +LD HQ
Sbjct: 24 RSSELDRHQ 32
>XP_006714838
          Length = 955

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KSVQLDSHQ 9
          KSVQ  SH+
Sbjct: 44 KSVQPQSHK 52
>XP_005268463
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSVQLDSHQ 9
           KSVQ  SH+
Sbjct: 185 KSVQPQSHK 193
>XP_005268461
          Length = 1096

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSVQLDSHQ 9
           KSVQ  SH+
Sbjct: 185 KSVQPQSHK 193
>NP_004285
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  VQLDSHQ 9
          +QL SHQ
Sbjct: 23 IQLHSHQ 29
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.114    0.288 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 477,443
Number of extensions: 530
Number of successful extensions: 54
Number of sequences better than 10000.0: 54
Number of HSP's gapped: 54
Number of HSP's successfully gapped: 54
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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