Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              20     509
NP_733762                                                              20     509
XP_006713860                                                           20     509
XP_006713859                                                           20     509
XP_005247910                                                           20     509
XP_005247909                                                           20     509
NP_001106881                                                           18    1482
NP_002776                                                              18    1482
NP_976032                                                              18    1482
NP_001866                                                              17    2528
NP_001116105                                                           17    2528
NP_001116106                                                           17    2528
NP_001034568                                                           17    2528
XP_005268301                                                           17    2528
XP_006720407                                                           17    2528
NP_291021                                                              17    3301
NP_001091976                                                           17    3301
NP_001275702                                                           17    3301
NP_001277042                                                           17    3301
NP_057313                                                              17    3301
XP_006725459                                                           17    3301
XP_006725458                                                           17    3301
XP_006725457                                                           17    3301
XP_005278454                                                           17    3301
XP_005278453                                                           17    3301
XP_006718315                                                           17    3301
XP_005253032                                                           17    3301
XP_006718314                                                           17    3301
XP_005253031                                                           17    3301
XP_006718313                                                           17    3301
XP_005253030                                                           17    3301
NP_000831                                                              17    4312
NP_085143                                                              17    4312
NP_001123481                                                           17    4312
NP_872431                                                              17    4312
XP_006719218                                                           17    4312
XP_006712069                                                           17    4312
XP_006712068                                                           17    4312
XP_005262670                                                           17    4312
NP_000724                                                              16    5631
NP_006436                                                              16    5631
NP_996882                                                              16    5631
NP_057092                                                              16    5631
NP_112536                                                              16    5631
NP_056337                                                              16    5631
XP_005264422                                                           16    5631
XP_005264421                                                           16    5631
NP_001180393                                                           16    5631
NP_008821                                                              16    7355
NP_001278414                                                           16    7355
NP_653309                                                              16    7355
NP_660339                                                              16    7355
NP_065744                                                              16    7355
XP_005258677                                                           16    7355
XP_005258487                                                           16    7355
NP_006197                                                              15    9605
NP_055598                                                              15    9605
NP_000928                                                              15    9605
NP_443132                                                              15    9605
NP_001026836                                                           15    9605
NP_955389                                                              15    9605
NP_937757                                                              15    9605
NP_937756                                                              15    9605
XP_006725628                                                           15    9605
XP_006725627                                                           15    9605
XP_005254865                                                           15    9605
XP_006714104                                                           15    9605
XP_005265800                                                           15    9605
XP_006714103                                                           15    9605
XP_006714102                                                           15    9605
NP_001026979                                                           15    9605
NP_006129                                                              15    9605
>NP_005179
          Length = 906

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           KSTI LTCN
Sbjct: 225 KSTIDLTCN 233
>NP_733762
          Length = 982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           KSTI LTCN
Sbjct: 217 KSTIDLTCN 225
>XP_006713860
          Length = 914

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           KSTI LTCN
Sbjct: 245 KSTIDLTCN 253
>XP_006713859
          Length = 966

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           KSTI LTCN
Sbjct: 245 KSTIDLTCN 253
>XP_005247910
          Length = 982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           KSTI LTCN
Sbjct: 217 KSTIDLTCN 225
>XP_005247909
          Length = 1010

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           KSTI LTCN
Sbjct: 245 KSTIDLTCN 253
>NP_001106881
          Length = 213

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TIVLTCN 9
          T++LTCN
Sbjct: 42 TVILTCN 48
>NP_002776
          Length = 335

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TIVLTCN 9
           T++LTCN
Sbjct: 164 TVILTCN 170
>NP_976032
          Length = 213

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TIVLTCN 9
          T++LTCN
Sbjct: 42 TVILTCN 48
>NP_001866
          Length = 1500

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSTIVLTCN 9
            K T+V+ CN
Sbjct: 1008 KKTVVVNCN 1016
>NP_001116105
          Length = 1506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSTIVLTCN 9
            K T+V+ CN
Sbjct: 1014 KKTVVVNCN 1022
>NP_001116106
          Length = 1049

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSTIVLTCN 9
           K T+V+ CN
Sbjct: 557 KKTVVVNCN 565
>NP_001034568
          Length = 823

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   STIVLTC 8
           ST+VLTC
Sbjct: 175 STLVLTC 181
>XP_005268301
          Length = 662

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  STIVLTC 8
          ST+VLTC
Sbjct: 14 STLVLTC 20
>XP_006720407
          Length = 813

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   STIVLTC 8
           ST+VLTC
Sbjct: 165 STLVLTC 171
>NP_291021
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           K ++VLTC+
Sbjct: 159 KGSVVLTCH 167
>NP_001091976
          Length = 293

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           K ++VLTC+
Sbjct: 159 KGSVVLTCH 167
>NP_001275702
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KSTIVLTCN 9
          K ++VLTC+
Sbjct: 31 KGSVVLTCH 39
>NP_001277042
          Length = 164

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KSTIVLTCN 9
          K ++VLTC+
Sbjct: 31 KGSVVLTCH 39
>NP_057313
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 242 KSTLILVC 249
>XP_006725459
          Length = 164

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KSTIVLTCN 9
          K ++VLTC+
Sbjct: 31 KGSVVLTCH 39
>XP_006725458
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           K ++VLTC+
Sbjct: 159 KGSVVLTCH 167
>XP_006725457
          Length = 293

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           K ++VLTC+
Sbjct: 159 KGSVVLTCH 167
>XP_005278454
          Length = 292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           K ++VLTC+
Sbjct: 159 KGSVVLTCH 167
>XP_005278453
          Length = 293

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSTIVLTCN 9
           K ++VLTC+
Sbjct: 159 KGSVVLTCH 167
>XP_006718315
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 242 KSTLILVC 249
>XP_005253032
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 242 KSTLILVC 249
>XP_006718314
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 242 KSTLILVC 249
>XP_005253031
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 242 KSTLILVC 249
>XP_006718313
          Length = 276

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 242 KSTLILVC 249
>XP_005253030
          Length = 336

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST++L C
Sbjct: 302 KSTLILVC 309
>NP_000831
          Length = 879

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KSTIVLTCN 9
           + T++L CN
Sbjct: 723 RETVILKCN 731
>NP_085143
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST+V TC
Sbjct: 139 KSTLVPTC 146
>NP_001123481
          Length = 908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STIVLTCN 9
           +T+V TCN
Sbjct: 760 NTVVKTCN 767
>NP_872431
          Length = 908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STIVLTCN 9
           +T+V TCN
Sbjct: 760 NTVVKTCN 767
>XP_006719218
          Length = 665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KSTIVLTC 8
           KST+V TC
Sbjct: 139 KSTLVPTC 146
>XP_006712069
          Length = 908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STIVLTCN 9
           +T+V TCN
Sbjct: 760 NTVVKTCN 767
>XP_006712068
          Length = 908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STIVLTCN 9
           +T+V TCN
Sbjct: 760 NTVVKTCN 767
>XP_005262670
          Length = 908

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   STIVLTCN 9
           +T+V TCN
Sbjct: 760 NTVVKTCN 767
>NP_000724
          Length = 207

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  STIVLTC 8
          +T++LTC
Sbjct: 43 TTVILTC 49
>NP_006436
          Length = 2335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1    KSTIVLTCN 9
            + TI++TC+
Sbjct: 2209 EKTIIITCS 2217
>NP_996882
          Length = 1551

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    STIVLTCN 9
            S+I+L CN
Sbjct: 1522 SSIILDCN 1529
>NP_057092
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KSTIVLTC 8
          K+TI+L C
Sbjct: 44 KTTIILRC 51
>NP_112536
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   TIVLTCN 9
           T++LTC+
Sbjct: 164 TVILTCD 170
>NP_056337
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KSTIVLTC 8
          K+TI+L C
Sbjct: 44 KTTIILRC 51
>XP_005264422
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KSTIVLTC 8
          K+TI+L C
Sbjct: 44 KTTIILRC 51
>XP_005264421
          Length = 374

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KSTIVLTC 8
          K+TI+L C
Sbjct: 44 KTTIILRC 51
>NP_001180393
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KSTIVLTC 8
          K+TI+L C
Sbjct: 44 KTTIILRC 51
>NP_008821
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSTIVLTC 8
           K  +VLTC
Sbjct: 161 KDIVVLTC 168
>NP_001278414
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSTIVLTC 8
           K  +VLTC
Sbjct: 161 KDIVVLTC 168
>NP_653309
          Length = 1434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    STIVLTCN 9
            STIVLT N
Sbjct: 1228 STIVLTGN 1235
>NP_660339
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           T+VLTC
Sbjct: 240 TLVLTC 245
>NP_065744
          Length = 2113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   STIVLTC 8
           ST++L+C
Sbjct: 390 STVILSC 396
>XP_005258677
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           T+VLTC
Sbjct: 240 TLVLTC 245
>XP_005258487
          Length = 244

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSTIVLTC 8
           K  +VLTC
Sbjct: 140 KDIVVLTC 147
>NP_006197
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           TIV+TC
Sbjct: 230 TIVVTC 235
>NP_055598
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KSTIVLTC 8
           K+T++L+C
Sbjct: 154 KATLLLSC 161
>NP_000928
          Length = 1970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   STIVLTCN 9
           S +VL CN
Sbjct: 975 SKVVLPCN 982
>NP_443132
          Length = 3538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    STIVLTCN 9
            STI+  CN
Sbjct: 1271 STIIYGCN 1278
>NP_001026836
          Length = 91

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  STIVLTCN 9
          STI + CN
Sbjct: 67 STIAMWCN 74
>NP_955389
          Length = 501

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KSTIVLTC 8
           K+T++L+C
Sbjct: 154 KATLLLSC 161
>NP_937757
          Length = 3667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    STIVLTCN 9
            STI+  CN
Sbjct: 1335 STIIYGCN 1342
>NP_937756
          Length = 3707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    STIVLTCN 9
            STI+  CN
Sbjct: 1375 STIIYGCN 1382
>XP_006725628
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KSTIVLTC 8
           K+T++L+C
Sbjct: 154 KATLLLSC 161
>XP_006725627
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KSTIVLTC 8
           K+T++L+C
Sbjct: 154 KATLLLSC 161
>XP_005254865
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KSTIVLTC 8
           K+T++L+C
Sbjct: 154 KATLLLSC 161
>XP_006714104
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           TIV+TC
Sbjct: 255 TIVVTC 260
>XP_005265800
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           TIV+TC
Sbjct: 230 TIVVTC 235
>XP_006714103
          Length = 1111

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           TIV+TC
Sbjct: 252 TIVVTC 257
>XP_006714102
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TIVLTC 8
           TIV+TC
Sbjct: 255 TIVVTC 260
>NP_001026979
          Length = 168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   STIVLTCN 9
           STI + CN
Sbjct: 144 STIAMWCN 151
>NP_006129
          Length = 214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   STIVLTCN 9
           STI + CN
Sbjct: 190 STIAMWCN 197
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.126    0.368 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 464,464
Number of extensions: 756
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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