Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              22     134
XP_006713721                                                           22     134
NP_003096                                                              17    4312
NP_055845                                                              16    5631
NP_001135865                                                           16    5631
NP_006394                                                              16    5631
NP_001257962                                                           16    5631
NP_001170977                                                           16    5631
NP_001628                                                              16    5631
NP_872415                                                              16    5631
XP_005258920                                                           16    5631
XP_005258919                                                           16    5631
XP_005258917                                                           16    5631
XP_005248148                                                           16    5631
XP_005248147                                                           16    5631
XP_005248146                                                           16    5631
XP_005248145                                                           16    5631
XP_005248144                                                           16    5631
XP_005248143                                                           16    5631
XP_005248142                                                           16    5631
XP_005248141                                                           16    5631
XP_005248140                                                           16    5631
XP_005248139                                                           16    5631
NP_149094                                                              16    7355
NP_694967                                                              16    7355
NP_060830                                                              16    7355
NP_001277251                                                           16    7355
NP_005500                                                              16    7355
NP_001277250                                                           16    7355
NP_001162154                                                           16    7355
XP_005274615                                                           16    7355
XP_005248810                                                           16    7355
XP_006715597                                                           16    7355
XP_005248809                                                           16    7355
XP_005266893                                                           16    7355
XP_005271970                                                           16    7355
XP_005271969                                                           16    7355
XP_005271967                                                           16    7355
XP_005271966                                                           16    7355
NP_001695                                                              16    7355
NP_653176                                                              16    7355
NP_001265045                                                           15    9605
NP_001137435                                                           15    9605
NP_076493                                                              15    9605
NP_000416                                                              15    9605
NP_060452                                                              15    9605
NP_001032252                                                           15    9605
NP_852111                                                              15    9605
NP_000136                                                              15    9605
NP_009124                                                              15    9605
NP_078964                                                              15    9605
XP_005252650                                                           15    9605
XP_006717569                                                           15    9605
XP_006717306                                                           15    9605
XP_006717305                                                           15    9605
XP_005266153                                                           15    9605
XP_006717304                                                           15    9605
XP_006714136                                                           15    9605
XP_005273230                                                           15    9605
XP_005273226                                                           15    9605
XP_006711471                                                           15    9605
NP_005192                                                              15    9605
NP_003077                                                              15    9605
>NP_006209
          Length = 1068

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KSQMHNKTV 9
           KS+MHNKTV
Sbjct: 672 KSEMHNKTV 680
>XP_006713721
          Length = 1068

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KSQMHNKTV 9
           KS+MHNKTV
Sbjct: 672 KSEMHNKTV 680
>NP_003096
          Length = 2214

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SQMHNKTV 9
            + +HNKTV
Sbjct: 1890 TSLHNKTV 1897
>NP_055845
          Length = 3013

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 652 AQMHNK 657
>NP_001135865
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSQMHNKTV 9
           K+Q HNK +
Sbjct: 595 KAQAHNKAL 603
>NP_006394
          Length = 834

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSQMHNKTV 9
           K+Q HNK +
Sbjct: 595 KAQAHNKAL 603
>NP_001257962
          Length = 685

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSQMHNKTV 9
           K+Q HNK +
Sbjct: 446 KAQAHNKAL 454
>NP_001170977
          Length = 688

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SQMHNKTV 9
          +Q+HN TV
Sbjct: 55 AQVHNSTV 62
>NP_001628
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  SQMHNKTV 9
          +Q+HN TV
Sbjct: 55 AQVHNSTV 62
>NP_872415
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSQMHNKT 8
           K Q HNK+
Sbjct: 132 KDQQHNKS 139
>XP_005258920
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSQMHNKT 8
           K Q HNK+
Sbjct: 96  KDQQHNKS 103
>XP_005258919
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSQMHNKT 8
           K Q HNK+
Sbjct: 96  KDQQHNKS 103
>XP_005258917
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSQMHNKT 8
           K Q HNK+
Sbjct: 132 KDQQHNKS 139
>XP_005248148
          Length = 3028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 667 AQMHNK 672
>XP_005248147
          Length = 3028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 667 AQMHNK 672
>XP_005248146
          Length = 3073

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 759 AQMHNK 764
>XP_005248145
          Length = 3079

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 718 AQMHNK 723
>XP_005248144
          Length = 3099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 744 AQMHNK 749
>XP_005248143
          Length = 3105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 744 AQMHNK 749
>XP_005248142
          Length = 3114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 759 AQMHNK 764
>XP_005248141
          Length = 3119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 759 AQMHNK 764
>XP_005248140
          Length = 3119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 759 AQMHNK 764
>XP_005248139
          Length = 3120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   SQMHNK 7
           +QMHNK
Sbjct: 759 AQMHNK 764
>NP_149094
          Length = 686

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SQMHNKT 8
           S MHNK+
Sbjct: 598 SSMHNKS 604
>NP_694967
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 222 QRHNKTL 228
>NP_060830
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 216 QRHNKTL 222
>NP_001277251
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2196 KEQTHSKTL 2204

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    QMHNKT 8
            Q HNKT
Sbjct: 2662 QCHNKT 2667
>NP_005500
          Length = 3027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2369 KEQTHSKTL 2377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    QMHNKT 8
            Q HNKT
Sbjct: 2835 QCHNKT 2840
>NP_001277250
          Length = 3048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2369 KEQTHSKTL 2377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    QMHNKT 8
            Q HNKT
Sbjct: 2856 QCHNKT 2861
>NP_001162154
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  QMHNKTV 9
          Q HNKT+
Sbjct: 84 QRHNKTL 90
>XP_005274615
          Length = 440

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 216 QRHNKTL 222
>XP_005248810
          Length = 1078

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KSQMHNKTV 9
           ++Q HNK++
Sbjct: 932 QTQTHNKSI 940
>XP_006715597
          Length = 1489

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KSQMHNKTV 9
           ++Q HNK++
Sbjct: 932 QTQTHNKSI 940
>XP_005248809
          Length = 1522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KSQMHNKTV 9
           ++Q HNK++
Sbjct: 932 QTQTHNKSI 940
>XP_005266893
          Length = 684

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 222 QRHNKTL 228
>XP_005271970
          Length = 2931

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2369 KEQTHSKTL 2377
>XP_005271969
          Length = 3020

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2303 KEQTHSKTL 2311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    QMHNKT 8
            Q HNKT
Sbjct: 2828 QCHNKT 2833
>XP_005271967
          Length = 3065

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2369 KEQTHSKTL 2377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    QMHNKT 8
            Q HNKT
Sbjct: 2873 QCHNKT 2878
>XP_005271966
          Length = 3086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KSQMHNKTV 9
            K Q H+KT+
Sbjct: 2369 KEQTHSKTL 2377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3    QMHNKT 8
            Q HNKT
Sbjct: 2894 QCHNKT 2899
>NP_001695
          Length = 1522

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KSQMHNKTV 9
           ++Q HNK++
Sbjct: 932 QTQTHNKSI 940
>NP_653176
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KSQMHNK 7
           KSQ+H K
Sbjct: 301 KSQLHKK 307
>NP_001265045
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 291 QNHNKTL 297
>NP_001137435
          Length = 1248

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 286 QNHNKTL 292
>NP_076493
          Length = 1253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 291 QNHNKTL 297
>NP_000416
          Length = 1257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   QMHNKTV 9
           Q HNKT+
Sbjct: 291 QNHNKTL 297
>NP_060452
          Length = 490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SQMHNKT 8
           +++HNKT
Sbjct: 130 AEIHNKT 136
>NP_001032252
          Length = 290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SQMHNKT 8
           +++HNKT
Sbjct: 130 AEIHNKT 136
>NP_852111
          Length = 669

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           KSQ HN  +
Sbjct: 400 KSQYHNYAI 408
>NP_000136
          Length = 695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           KSQ HN  +
Sbjct: 426 KSQYHNYAI 434
>NP_009124
          Length = 324

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HNKTV 9
           HNKTV
Sbjct: 266 HNKTV 270
>NP_078964
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  KSQMHNK 7
          KSQ HN+
Sbjct: 12 KSQAHNE 18
>XP_005252650
          Length = 692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  KSQMHNK 7
          KSQ HN+
Sbjct: 12 KSQAHNE 18
>XP_006717569
          Length = 1278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KSQMHNK 7
           KSQ HN+
Sbjct: 598 KSQAHNE 604
>XP_006717306
          Length = 1441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           K Q HNK +
Sbjct: 336 KFQQHNKAL 344
>XP_006717305
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           K Q HNK +
Sbjct: 336 KFQQHNKAL 344
>XP_005266153
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           K Q HNK +
Sbjct: 336 KFQQHNKAL 344
>XP_006717304
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           K Q HNK +
Sbjct: 336 KFQQHNKAL 344
>XP_006714136
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   HNKTV 9
           HNKTV
Sbjct: 289 HNKTV 293
>XP_005273230
          Length = 251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SQMHNKT 8
           +++HNKT
Sbjct: 130 AEIHNKT 136
>XP_005273226
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SQMHNKT 8
           +++HNKT
Sbjct: 130 AEIHNKT 136
>XP_006711471
          Length = 492

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   SQMHNKT 8
           +++HNKT
Sbjct: 130 AEIHNKT 136
>NP_005192
          Length = 355

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KSQMHNKT 8
           + Q HNKT
Sbjct: 227 RCQNHNKT 234
>NP_003077
          Length = 1469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KSQMHNKTV 9
           K Q HNK +
Sbjct: 336 KFQQHNKAL 344
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.107    0.280 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 517,920
Number of extensions: 756
Number of successful extensions: 69
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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