Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              20     509
XP_006716142                                                           20     509
XP_005250088                                                           20     509
XP_006716141                                                           20     509
XP_005250085                                                           20     509
XP_006716140                                                           20     509
XP_005250084                                                           20     509
XP_005250083                                                           20     509
XP_005250082                                                           20     509
NP_003473                                                              18    1135
NP_001340                                                              18    1135
XP_006719679                                                           18    1135
XP_005269219                                                           18    1135
XP_006719678                                                           18    1135
XP_006719677                                                           18    1135
NP_001014990                                                           17    3301
NP_054899                                                              17    3301
NP_003096                                                              16    5631
NP_001130                                                              16    7355
NP_001136244                                                           15    9605
NP_001136243                                                           15    9605
NP_001153605                                                           15    9605
NP_062816                                                              15    9605
NP_001153606                                                           15    9605
NP_001153602                                                           15    9605
NP_001153604                                                           15    9605
NP_008923                                                              15    9605
NP_964013                                                              15    9605
NP_001128689                                                           15    9605
>NP_733751
          Length = 4911

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4770 KSNVYLARS 4778
>XP_006716142
          Length = 4927

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4786 KSNVYLARS 4794
>XP_005250088
          Length = 4928

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4787 KSNVYLARS 4795
>XP_006716141
          Length = 4959

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4818 KSNVYLARS 4826
>XP_005250085
          Length = 4979

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4838 KSNVYLARS 4846
>XP_006716140
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4841 KSNVYLARS 4849
>XP_005250084
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4841 KSNVYLARS 4849
>XP_005250083
          Length = 4982

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4841 KSNVYLARS 4849
>XP_005250082
          Length = 4983

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            KSNVYLA+S
Sbjct: 4842 KSNVYLARS 4850
>NP_003473
          Length = 5537

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            K+NVYLA+S
Sbjct: 5396 KNNVYLARS 5404
>NP_001340
          Length = 501

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KSNVYLAQS 9
           K+N YLAQS
Sbjct: 241 KNNAYLAQS 249
>XP_006719679
          Length = 5536

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            K+NVYLA+S
Sbjct: 5395 KNNVYLARS 5403
>XP_005269219
          Length = 5537

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            K+NVYLA+S
Sbjct: 5396 KNNVYLARS 5404
>XP_006719678
          Length = 5539

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            K+NVYLA+S
Sbjct: 5398 KNNVYLARS 5406
>XP_006719677
          Length = 5540

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1    KSNVYLAQS 9
            K+NVYLA+S
Sbjct: 5399 KNNVYLARS 5407
>NP_001014990
          Length = 126

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  KSNVYLAQS 9
          +SN+Y+A+S
Sbjct: 51 RSNLYIAES 59
>NP_054899
          Length = 206

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KSNVYLAQS 9
           +SN+Y+A+S
Sbjct: 131 RSNLYIAES 139
>NP_003096
          Length = 2214

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSNVYLAQS 9
           K+NVY++ S
Sbjct: 517 KTNVYISSS 525
>NP_001130
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KSNVYLA 7
           K N+YLA
Sbjct: 310 KGNIYLA 316
>NP_001136244
          Length = 1677

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NVYLAQS 9
            N+Y+AQ+
Sbjct: 1539 NIYIAQN 1545
>NP_001136243
          Length = 1682

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    NVYLAQS 9
            N+Y+AQ+
Sbjct: 1544 NIYIAQN 1550
>NP_001153605
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSNVYLAQS 9
           K NV +AQS
Sbjct: 807 KENVQVAQS 815
>NP_062816
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSNVYLAQS 9
           K NV +AQS
Sbjct: 788 KENVQVAQS 796
>NP_001153606
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSNVYLAQS 9
           K NV +AQS
Sbjct: 678 KENVQVAQS 686
>NP_001153602
          Length = 923

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSNVYLAQS 9
           K NV +AQS
Sbjct: 779 KENVQVAQS 787
>NP_001153604
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSNVYLAQS 9
           K NV +AQS
Sbjct: 798 KENVQVAQS 806
>NP_008923
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYLAQS 9
           N+YLAQ+
Sbjct: 204 NLYLAQN 210
>NP_964013
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYLAQS 9
           N+YLAQ+
Sbjct: 204 NLYLAQN 210
>NP_001128689
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NVYLAQS 9
           N+YLAQ+
Sbjct: 204 NLYLAQN 210
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.111    0.267 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 380,258
Number of extensions: 412
Number of successful extensions: 29
Number of sequences better than 10000.0: 29
Number of HSP's gapped: 29
Number of HSP's successfully gapped: 29
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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