Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     509
NP_055869                                                              17    3301
NP_001006948                                                           17    3301
XP_006719360                                                           17    3301
XP_005268797                                                           17    3301
XP_005268796                                                           17    3301
XP_005268795                                                           17    3301
XP_005268794                                                           17    3301
NP_835366                                                              17    4312
NP_835365                                                              17    4312
NP_835364                                                              17    4312
NP_000546                                                              17    4312
XP_005262148                                                           17    4312
XP_005265204                                                           17    4312
XP_006713218                                                           17    4312
XP_006713214                                                           17    4312
NP_570971                                                              16    5631
NP_064590                                                              16    5631
XP_006720476                                                           16    5631
XP_005277471                                                           16    5631
XP_006711526                                                           16    5631
XP_006711525                                                           16    5631
XP_006711524                                                           16    5631
NP_001257354                                                           16    7355
NP_660333                                                              16    7355
NP_003609                                                              16    7355
NP_055504                                                              16    7355
NP_001277192                                                           16    7355
NP_056011                                                              16    7355
NP_001124479                                                           16    7355
NP_872343                                                              16    7355
NP_653292                                                              16    7355
NP_001157118                                                           16    7355
XP_005262928                                                           16    7355
XP_005262927                                                           16    7355
XP_005262926                                                           16    7355
XP_006712687                                                           16    7355
XP_006712686                                                           16    7355
XP_006712685                                                           16    7355
XP_006712684                                                           16    7355
XP_006712683                                                           16    7355
XP_006712682                                                           16    7355
XP_006712681                                                           16    7355
XP_005246730                                                           16    7355
XP_005246729                                                           16    7355
XP_006712680                                                           16    7355
XP_006712679                                                           16    7355
NP_001138615                                                           16    7355
NP_001073862                                                           16    7355
NP_056359                                                              15    9605
NP_001138626                                                           15    9605
NP_001028676                                                           15    9605
NP_001364                                                              15    9605
NP_695013                                                              15    9605
NP_695014                                                              15    9605
NP_659426                                                              15    9605
NP_006663                                                              15    9605
NP_001117                                                              15    9605
NP_149349                                                              15    9605
NP_695015                                                              15    9605
XP_006726639                                                           15    9605
XP_006711798                                                           15    9605
NP_696961                                                              15    9605
>NP_002430
          Length = 1137

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KSIY PLEL
Sbjct: 226 KSIYTPLEL 234
>NP_055869
          Length = 1464

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KS+Y+P E+
Sbjct: 489 KSLYLPQEM 497
>NP_001006948
          Length = 522

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KS+Y+P E+
Sbjct: 489 KSLYLPQEM 497
>XP_006719360
          Length = 1011

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KSIYMPLEL 9
          KS+Y+P E+
Sbjct: 36 KSLYLPQEM 44
>XP_005268797
          Length = 1384

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KS+Y+P E+
Sbjct: 489 KSLYLPQEM 497
>XP_005268796
          Length = 1403

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KS+Y+P E+
Sbjct: 428 KSLYLPQEM 436
>XP_005268795
          Length = 1416

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KS+Y+P E+
Sbjct: 441 KSLYLPQEM 449
>XP_005268794
          Length = 1443

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KS+Y+P E+
Sbjct: 489 KSLYLPQEM 497
>NP_835366
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K +Y+PL L
Sbjct: 342 KDLYLPLSL 350
>NP_835365
          Length = 365

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K +Y+PL L
Sbjct: 347 KDLYLPLSL 355
>NP_835364
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K +Y+PL L
Sbjct: 342 KDLYLPLSL 350
>NP_000546
          Length = 441

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K +Y+PL L
Sbjct: 423 KDLYLPLSL 431
>XP_005262148
          Length = 434

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K +Y+PL L
Sbjct: 416 KDLYLPLSL 424
>XP_005265204
          Length = 2256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K  Y+PLEL
Sbjct: 173 KDSYVPLEL 181
>XP_006713218
          Length = 2282

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K  Y+PLEL
Sbjct: 199 KDSYVPLEL 207
>XP_006713214
          Length = 2311

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           K  Y+PLEL
Sbjct: 228 KDSYVPLEL 236
>NP_570971
          Length = 926

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 343 IYLPLEV 349
>NP_064590
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 334 IYLPLEV 340
>XP_006720476
          Length = 933

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 350 IYLPLEV 356
>XP_005277471
          Length = 764

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 255 IYLPLEV 261
>XP_006711526
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 334 IYLPLEV 340
>XP_006711525
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 334 IYLPLEV 340
>XP_006711524
          Length = 843

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IYMPLEL 9
           IY+PLE+
Sbjct: 334 IYLPLEV 340
>NP_001257354
          Length = 873

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KSI++P E+
Sbjct: 419 KSIFIPQEM 427
>NP_660333
          Length = 1321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SIYMPLEL 9
            S+Y PL+L
Sbjct: 1018 SLYYPLDL 1025
>NP_003609
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           KSI++P E+
Sbjct: 440 KSIFIPQEM 448
>NP_055504
          Length = 2186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1203 SLYMPL 1208
>NP_001277192
          Length = 2180

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1197 SLYMPL 1202
>NP_056011
          Length = 1609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SIYMPLEL 9
            S Y PLEL
Sbjct: 1456 SAYCPLEL 1463
>NP_001124479
          Length = 1610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SIYMPLEL 9
            S Y PLEL
Sbjct: 1457 SAYCPLEL 1464
>NP_872343
          Length = 279

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  SIYMPLE 8
          S Y+PLE
Sbjct: 77 SFYLPLE 83
>NP_653292
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YMPLEL 9
           Y+PLEL
Sbjct: 545 YLPLEL 550
>NP_001157118
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SIYMPLE 8
           S Y+PLE
Sbjct: 250 SFYLPLE 256
>XP_005262928
          Length = 965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SIYMPLEL 9
           S Y PLEL
Sbjct: 812 SAYCPLEL 819
>XP_005262927
          Length = 1526

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SIYMPLEL 9
            S Y PLEL
Sbjct: 1373 SAYCPLEL 1380
>XP_005262926
          Length = 1609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    SIYMPLEL 9
            S Y PLEL
Sbjct: 1456 SAYCPLEL 1463
>XP_006712687
          Length = 2166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712686
          Length = 2173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712685
          Length = 2175

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712684
          Length = 2189

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1197 SLYMPL 1202
>XP_006712683
          Length = 2195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1203 SLYMPL 1208
>XP_006712682
          Length = 2199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712681
          Length = 2199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_005246730
          Length = 2199

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_005246729
          Length = 2201

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712680
          Length = 2206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>XP_006712679
          Length = 2208

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    SIYMPL 7
            S+YMPL
Sbjct: 1216 SLYMPL 1221
>NP_001138615
          Length = 404

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   SIYMPLE 8
           S Y+PLE
Sbjct: 202 SFYLPLE 208
>NP_001073862
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KSIYMPLEL 9
           +S+Y PL+L
Sbjct: 392 QSMYYPLQL 400
>NP_056359
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSIYMPLE 8
           KS+Y PL+
Sbjct: 144 KSMYPPLD 151
>NP_001138626
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           KS+Y P +L
Sbjct: 185 KSLYNPYDL 193
>NP_001028676
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KSIYMPLE 8
           KS+Y PL+
Sbjct: 144 KSMYPPLD 151
>NP_001364
          Length = 4515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           KS+Y P +L
Sbjct: 185 KSLYNPYDL 193
>NP_695013
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SIYMPLEL 9
           SIYMP  L
Sbjct: 245 SIYMPAVL 252
>NP_695014
          Length = 405

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SIYMPLEL 9
           SIYMP  L
Sbjct: 245 SIYMPAVL 252
>NP_659426
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           KS+Y P +L
Sbjct: 185 KSLYNPYDL 193
>NP_006663
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IYMPLEL 9
           I MPLEL
Sbjct: 213 IVMPLEL 219
>NP_001117
          Length = 456

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           KSIY  LE+
Sbjct: 203 KSIYPTLEI 211
>NP_149349
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   SIYMPLEL 9
           SIYMP  L
Sbjct: 245 SIYMPAVL 252
>NP_695015
          Length = 253

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  SIYMPLEL 9
          SIYMP  L
Sbjct: 63 SIYMPAVL 70
>XP_006726639
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           KS++ P EL
Sbjct: 189 KSLHFPCEL 197
>XP_006711798
          Length = 4586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KSIYMPLEL 9
           KS+Y P +L
Sbjct: 185 KSLYNPYDL 193
>NP_696961
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IYMPLEL 9
           I MPLEL
Sbjct: 215 IVMPLEL 221
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.141    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 607,338
Number of extensions: 1054
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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