Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001181915                                                           18    1135
NP_000258                                                              18    1135
NP_001035957                                                           18    1135
XP_006721991                                                           18    1135
XP_006721990                                                           18    1135
XP_006721989                                                           18    1135
XP_005258041                                                           18    1135
XP_006721988                                                           18    1135
XP_006721987                                                           18    1135
XP_006721986                                                           18    1135
XP_005258040                                                           18    1135
XP_006721985                                                           18    1135
XP_006710703                                                           18    1135
NP_001229510                                                           16    7355
NP_061866                                                              16    7355
NP_001269723                                                           16    7355
NP_055705                                                              16    7355
NP_001035924                                                           16    7355
NP_878913                                                              16    7355
XP_005260790                                                           16    7355
XP_005260787                                                           16    7355
XP_005260789                                                           16    7355
XP_006723640                                                           16    7355
XP_006723639                                                           16    7355
XP_005260788                                                           16    7355
XP_006723638                                                           16    7355
XP_006723637                                                           16    7355
XP_006723636                                                           16    7355
XP_006713549                                                           16    7355
NP_001231509                                                           15    9605
NP_002728                                                              15    9605
NP_003487                                                              15    9605
>NP_001181915
          Length = 517

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 309 KRVMALLR 316
>NP_000258
          Length = 2818

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 757 KRVMALLR 764
>NP_001035957
          Length = 2839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 757 KRVMALLR 764
>XP_006721991
          Length = 1632

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 767 KRVMALLR 774
>XP_006721990
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 767 KRVMALLR 774
>XP_006721989
          Length = 2823

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 767 KRVMALLR 774
>XP_005258041
          Length = 2836

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 757 KRVMALLR 764
>XP_006721988
          Length = 2846

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 767 KRVMALLR 774
>XP_006721987
          Length = 2849

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 767 KRVMALLR 774
>XP_006721986
          Length = 2854

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 754 KRVMALLR 761
>XP_005258040
          Length = 2857

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 757 KRVMALLR 764
>XP_006721985
          Length = 2867

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 767 KRVMALLR 774
>XP_006710703
          Length = 552

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   KRVMALLR 8
           KRVMALLR
Sbjct: 309 KRVMALLR 316
>NP_001229510
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 718 KKVMLLLRV 726
>NP_061866
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 669 KKVMLLLRV 677
>NP_001269723
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           KR+MAL +L
Sbjct: 182 KRIMALEKL 190
>NP_055705
          Length = 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           KR+MAL +L
Sbjct: 182 KRIMALEKL 190
>NP_001035924
          Length = 1133

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           KR+MAL +L
Sbjct: 422 KRIMALEKL 430
>NP_878913
          Length = 1135

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           KR+MAL +L
Sbjct: 422 KRIMALEKL 430
>XP_005260790
          Length = 689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 463 KKVMLLLRV 471
>XP_005260787
          Length = 861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 635 KKVMLLLRV 643
>XP_005260789
          Length = 850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 624 KKVMLLLRV 632
>XP_006723640
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 669 KKVMLLLRV 677
>XP_006723639
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 669 KKVMLLLRV 677
>XP_005260788
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 669 KKVMLLLRV 677
>XP_006723638
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 669 KKVMLLLRV 677
>XP_006723637
          Length = 895

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 669 KKVMLLLRV 677
>XP_006723636
          Length = 944

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           K+VM LLR+
Sbjct: 718 KKVMLLLRV 726
>XP_006713549
          Length = 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVMALLRL 9
           KR+MAL +L
Sbjct: 182 KRIMALEKL 190
>NP_001231509
          Length = 3859

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRVMALLRL 9
            +RV+ LLRL
Sbjct: 3543 ERVLQLLRL 3551
>NP_002728
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRVMALL 7
           KRV+ALL
Sbjct: 388 KRVLALL 394
>NP_003487
          Length = 3830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRVMALLRL 9
            +RV+ LLRL
Sbjct: 3514 ERVLQLLRL 3522
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.351    0.153    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 247,989
Number of extensions: 433
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.9 bits)
S2: 28 (15.4 bits)

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