Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_004351                                                              20     390
NP_071351                                                              16    5631
NP_001157790                                                           16    7355
NP_001265390                                                           16    7355
NP_001265389                                                           16    7355
NP_055715                                                              16    7355
NP_001265387                                                           16    7355
NP_001157791                                                           16    7355
NP_001157789                                                           16    7355
NP_001448                                                              16    7355
NP_001269166                                                           16    7355
NP_001269167                                                           16    7355
NP_036307                                                              16    7355
NP_208385                                                              16    7355
NP_078907                                                              16    7355
NP_075049                                                              16    7355
NP_071896                                                              16    7355
NP_932348                                                              16    7355
NP_612808                                                              16    7355
NP_945327                                                              16    7355
XP_005256402                                                           16    7355
XP_006722342                                                           16    7355
XP_005271733                                                           16    7355
XP_006718971                                                           16    7355
XP_006718969                                                           16    7355
XP_006718968                                                           16    7355
XP_005271730                                                           16    7355
XP_005252908                                                           16    7355
XP_005270105                                                           16    7355
XP_006713130                                                           16    7355
XP_005265039                                                           16    7355
XP_005265038                                                           16    7355
XP_005265035                                                           16    7355
XP_005265034                                                           16    7355
NP_002464                                                              15    9605
NP_075044                                                              15    9605
NP_060484                                                              15    9605
NP_073739                                                              15    9605
NP_005036                                                              15    9605
NP_774959                                                              15    9605
NP_001258875                                                           15    9605
NP_003053                                                              15    9605
NP_689905                                                              15    9605
NP_775102                                                              15    9605
NP_054722                                                              15    9605
NP_001243727                                                           15    9605
NP_001158058                                                           15    9605
NP_001011551                                                           15    9605
XP_005260342                                                           15    9605
XP_005257137                                                           15    9605
XP_005257136                                                           15    9605
XP_005257135                                                           15    9605
XP_005256326                                                           15    9605
XP_006711681                                                           15    9605
XP_006711680                                                           15    9605
XP_005245637                                                           15    9605
>NP_004351
          Length = 882

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KRVEVSKDF 9
           KRVEVS+DF
Sbjct: 491 KRVEVSEDF 499
>NP_071351
          Length = 2752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KRVEVSKD 8
            K VEV+KD
Sbjct: 1991 KNVEVNKD 1998
>NP_001157790
          Length = 2591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001265390
          Length = 1128

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVEVSKDF 9
           K +E+SKD+
Sbjct: 740 KSLEISKDW 748
>NP_001265389
          Length = 1174

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVEVSKDF 9
           K +E+SKD+
Sbjct: 786 KSLEISKDW 794
>NP_055715
          Length = 1166

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVEVSKDF 9
           K +E+SKD+
Sbjct: 778 KSLEISKDW 786
>NP_001265387
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVEVSKDF 9
           K +E+SKD+
Sbjct: 845 KSLEISKDW 853
>NP_001157791
          Length = 2578

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001157789
          Length = 2633

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001448
          Length = 2602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_001269166
          Length = 893

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR++V KD
Sbjct: 685 KRIKVEKD 692
>NP_001269167
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR++V KD
Sbjct: 614 KRIKVEKD 621
>NP_036307
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVEVSKD 8
           R+E+SKD
Sbjct: 311 RIEMSKD 317
>NP_208385
          Length = 415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVEVSKD 8
           R+E+SKD
Sbjct: 311 RIEMSKD 317
>NP_078907
          Length = 507

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           K VEV +DF
Sbjct: 477 KFVEVERDF 485
>NP_075049
          Length = 823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR++V KD
Sbjct: 615 KRIKVEKD 622
>NP_071896
          Length = 800

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KRVEVSKD 8
           K VEV KD
Sbjct: 430 KEVEVKKD 437
>NP_932348
          Length = 915

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVSKDF 9
           E+SKDF
Sbjct: 511 EISKDF 516
>NP_612808
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR++V KD
Sbjct: 686 KRIKVEKD 693
>NP_945327
          Length = 599

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KRV ++KD
Sbjct: 383 KRVSINKD 390
>XP_005256402
          Length = 751

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVSKDF 9
           E+SKDF
Sbjct: 511 EISKDF 516
>XP_006722342
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   EVSKDF 9
           E+SKDF
Sbjct: 522 EISKDF 527
>XP_005271733
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           K VEV +DF
Sbjct: 299 KFVEVERDF 307
>XP_006718971
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           K VEV +DF
Sbjct: 299 KFVEVERDF 307
>XP_006718969
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           K VEV +DF
Sbjct: 299 KFVEVERDF 307
>XP_006718968
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           K VEV +DF
Sbjct: 299 KFVEVERDF 307
>XP_005271730
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           K VEV +DF
Sbjct: 618 KFVEVERDF 626
>XP_005252908
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   RVEVSKD 8
           R+E+SKD
Sbjct: 306 RIEMSKD 312
>XP_005270105
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KRVEVSKD 8
           K VEV KD
Sbjct: 430 KEVEVKKD 437
>XP_006713130
          Length = 2109

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265039
          Length = 2177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265038
          Length = 2181

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265035
          Length = 2609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>XP_005265034
          Length = 2622

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVEVSKD 8
           RVEV KD
Sbjct: 955 RVEVGKD 961
>NP_002464
          Length = 1960

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRVEVSKD 8
          K+V+V+KD
Sbjct: 63 KKVKVNKD 70
>NP_075044
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KRVEVSKDF 9
           KR+++ K+F
Sbjct: 634 KRIKLEKEF 642
>NP_060484
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KRVEVSKDF 9
           KR+++ K+F
Sbjct: 634 KRIKLEKEF 642
>NP_073739
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    KRVEVSKD 8
            K+V++S+D
Sbjct: 1395 KKVQISRD 1402
>NP_005036
          Length = 3460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RVEVSKDF 9
            R+E S+DF
Sbjct: 2040 RLEFSRDF 2047
>NP_774959
          Length = 3458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    RVEVSKDF 9
            R+E S+DF
Sbjct: 2040 RLEFSRDF 2047
>NP_001258875
          Length = 1530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KRVEVSKD 8
           KR+++SK+
Sbjct: 334 KRIDISKN 341
>NP_003053
          Length = 1523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KRVEVSKD 8
           KR+++SK+
Sbjct: 334 KRIDISKN 341
>NP_689905
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRVEVSKDF 9
          +R+E+SK F
Sbjct: 59 ERMELSKSF 67
>NP_775102
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR+EVS D
Sbjct: 383 KRLEVSVD 390
>NP_054722
          Length = 1227

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVEVSKDF 9
           R+EV +DF
Sbjct: 390 RLEVDEDF 397
>NP_001243727
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVEVSKDF 9
           KRV V +DF
Sbjct: 121 KRVAVVEDF 129
>NP_001158058
          Length = 3708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KRVEVSKD 8
           K++E+S+D
Sbjct: 625 KQIEISQD 632
>NP_001011551
          Length = 318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRVEVSKDF 9
          +R+E+SK F
Sbjct: 59 ERMELSKSF 67
>XP_005260342
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KRVEVSKDF 9
          KRV V +DF
Sbjct: 43 KRVAVVEDF 51
>XP_005257137
          Length = 614

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR+EVS D
Sbjct: 384 KRLEVSVD 391
>XP_005257136
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR+EVS D
Sbjct: 385 KRLEVSVD 392
>XP_005257135
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVEVSKD 8
           KR+EVS D
Sbjct: 386 KRLEVSVD 393
>XP_005256326
          Length = 1192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVEVSKDF 9
           R+EV +DF
Sbjct: 355 RLEVDEDF 362
>XP_006711681
          Length = 3448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KRVEVSKD 8
           K++E+S+D
Sbjct: 625 KQIEISQD 632
>XP_006711680
          Length = 3617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KRVEVSKD 8
           K++E+S+D
Sbjct: 534 KQIEISQD 541
>XP_005245637
          Length = 3683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KRVEVSKD 8
           K++E+S+D
Sbjct: 625 KQIEISQD 632
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.133    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,774
Number of extensions: 795
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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