Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           18    1135
NP_001020014                                                           18    1135
NP_055903                                                              18    1135
NP_001171661                                                           17    3301
NP_004245                                                              17    3301
NP_001171665                                                           17    3301
NP_001171662                                                           17    3301
NP_036443                                                              17    3301
XP_006717498                                                           17    3301
XP_006717497                                                           17    3301
NP_116239                                                              17    4312
NP_001245350                                                           17    4312
NP_001070736                                                           17    4312
NP_001120670                                                           16    5631
NP_009198                                                              16    5631
NP_060895                                                              16    5631
XP_005257055                                                           16    5631
XP_005257053                                                           16    5631
XP_005257052                                                           16    5631
NP_005903                                                              16    7355
NP_002042                                                              16    7355
NP_001002295                                                           16    7355
NP_001092909                                                           16    7355
NP_443124                                                              16    7355
NP_006460                                                              16    7355
NP_071332                                                              16    7355
XP_005252500                                                           16    7355
XP_005252499                                                           16    7355
XP_005244900                                                           16    7355
NP_003202                                                              16    7355
NP_006840                                                              16    7355
NP_001070248                                                           16    7355
NP_001263256                                                           15    9605
NP_001263255                                                           15    9605
NP_700357                                                              15    9605
NP_653186                                                              15    9605
NP_001264044                                                           15    9605
NP_001252542                                                           15    9605
NP_001010985                                                           15    9605
XP_006718494                                                           15    9605
XP_005273799                                                           15    9605
XP_006718493                                                           15    9605
XP_005250558                                                           15    9605
XP_006710676                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KRVAVLNGQ 9
          KRVAV NGQ
Sbjct: 71 KRVAVPNGQ 79
>NP_001020014
          Length = 1029

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           KRVAV NGQ
Sbjct: 107 KRVAVPNGQ 115
>NP_055903
          Length = 1723

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KRVAVLNGQ 9
          KRVAV NGQ
Sbjct: 71 KRVAVPNGQ 79
>NP_001171661
          Length = 542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RVAV NG+
Sbjct: 277 RRVAVFNGK 285
>NP_004245
          Length = 542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RVAV NG+
Sbjct: 277 RRVAVFNGK 285
>NP_001171665
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RVAV NG+
Sbjct: 154 RRVAVFNGK 162
>NP_001171662
          Length = 451

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RVAV NG+
Sbjct: 186 RRVAVFNGK 194
>NP_036443
          Length = 393

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVAVLNG 8
           KR+ VLNG
Sbjct: 341 KRILVLNG 348
>XP_006717498
          Length = 288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVAVLNG 8
           KR+ VLNG
Sbjct: 235 KRILVLNG 242
>XP_006717497
          Length = 394

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVAVLNG 8
           KR+ VLNG
Sbjct: 341 KRILVLNG 348
>NP_116239
          Length = 461

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           KR+A+L GQ
Sbjct: 321 KRLAMLRGQ 329
>NP_001245350
          Length = 296

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           KR+A+L GQ
Sbjct: 156 KRLAMLRGQ 164
>NP_001070736
          Length = 471

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           KR+A+L GQ
Sbjct: 331 KRLAMLRGQ 339
>NP_001120670
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVAVLNGQ 9
           +RV VL GQ
Sbjct: 531 RRVGVLQGQ 539
>NP_009198
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVAVLNGQ 9
           +RV VL GQ
Sbjct: 531 RRVGVLQGQ 539
>NP_060895
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           K++AV+ GQ
Sbjct: 418 KQIAVMRGQ 426
>XP_005257055
          Length = 578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVAVLNGQ 9
           +RV VL GQ
Sbjct: 304 RRVGVLQGQ 312
>XP_005257053
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVAVLNGQ 9
           +RV VL GQ
Sbjct: 531 RRVGVLQGQ 539
>XP_005257052
          Length = 805

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRVAVLNGQ 9
           +RV VL GQ
Sbjct: 531 RRVGVLQGQ 539
>NP_005903
          Length = 332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRVAVLNG 8
           KR+AVL G
Sbjct: 224 KRIAVLPG 231
>NP_002042
          Length = 443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  AVLNGQ 9
          AVLNGQ
Sbjct: 17 AVLNGQ 22
>NP_001002295
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  AVLNGQ 9
          AVLNGQ
Sbjct: 17 AVLNGQ 22
>NP_001092909
          Length = 1008

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   RVAVLNG 8
           RVA LNG
Sbjct: 424 RVAALNG 430
>NP_443124
          Length = 2459

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           R+AVL GQ
Sbjct: 636 RLAVLRGQ 643
>NP_006460
          Length = 642

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VAVLNGQ 9
           VAVLNG+
Sbjct: 554 VAVLNGK 560
>NP_071332
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRVAVLN 7
           KRV+VLN
Sbjct: 224 KRVSVLN 230
>XP_005252500
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  AVLNGQ 9
          AVLNGQ
Sbjct: 17 AVLNGQ 22
>XP_005252499
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  AVLNGQ 9
          AVLNGQ
Sbjct: 17 AVLNGQ 22
>XP_005244900
          Length = 424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VAVLNGQ 9
           VAVLNG+
Sbjct: 336 VAVLNGK 342
>NP_003202
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           R+AV NG+
Sbjct: 225 RIAVFNGK 232
>NP_006840
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   AVLNGQ 9
           AVLNGQ
Sbjct: 366 AVLNGQ 371
>NP_001070248
          Length = 991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           R+AVL GQ
Sbjct: 636 RLAVLRGQ 643
>NP_001263256
          Length = 445

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           RVA +NG+
Sbjct: 193 RVAAINGK 200
>NP_001263255
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           RVA +NG+
Sbjct: 267 RVAAINGK 274
>NP_700357
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RVAVLNGQ 9
          RVA +NG+
Sbjct: 80 RVAAINGK 87
>NP_653186
          Length = 553

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           RVA +NG+
Sbjct: 301 RVAAINGK 308
>NP_001264044
          Length = 4516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   AVLNGQ 9
           A+LNGQ
Sbjct: 498 AILNGQ 503
>NP_001252542
          Length = 331

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RV+V NG+
Sbjct: 97  RRVSVRNGE 105
>NP_001010985
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RV+V NG+
Sbjct: 97  RRVSVRNGE 105
>XP_006718494
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           RVA +NG+
Sbjct: 291 RVAAINGK 298
>XP_005273799
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           RVA +NG+
Sbjct: 326 RVAAINGK 333
>XP_006718493
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RVAVLNGQ 9
           RVA +NG+
Sbjct: 326 RVAAINGK 333
>XP_005250558
          Length = 1024

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RVAVLNGQ 9
           RVA++NG+
Sbjct: 485 RVALVNGK 492
>XP_006710676
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRVAVLNGQ 9
           +RV+V NG+
Sbjct: 97  RRVSVRNGE 105
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.133    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 440,526
Number of extensions: 716
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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