Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              20     390
NP_065928                                                              18    1935
XP_005256527                                                           18    1935
NP_000284                                                              17    4312
NP_689753                                                              17    4312
XP_005256040                                                           17    4312
NP_000072                                                              16    5631
NP_001166137                                                           16    5631
NP_001166136                                                           16    5631
NP_001166135                                                           16    5631
NP_066991                                                              16    5631
NP_001166134                                                           16    5631
XP_006722488                                                           16    5631
XP_006722487                                                           16    5631
XP_006722486                                                           16    5631
XP_006722485                                                           16    5631
XP_005266720                                                           16    5631
XP_006722484                                                           16    5631
XP_005266717                                                           16    5631
XP_005266715                                                           16    5631
XP_005273087                                                           16    5631
XP_006711794                                                           16    5631
XP_005273086                                                           16    5631
XP_005273085                                                           16    5631
XP_005273084                                                           16    5631
NP_004817                                                              16    7355
NP_001277716                                                           16    7355
NP_073572                                                              15    9605
NP_055625                                                              15    9605
NP_001073890                                                           15    9605
XP_006722755                                                           15    9605
XP_006711734                                                           15    9605
XP_006711733                                                           15    9605
XP_006711732                                                           15    9605
XP_006711731                                                           15    9605
XP_006711730                                                           15    9605
XP_006711729                                                           15    9605
XP_005245695                                                           15    9605
>NP_002430
          Length = 1137

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KRSKSIYMP 9
           KRSKSIY P
Sbjct: 223 KRSKSIYTP 231
>NP_065928
          Length = 4427

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+K +Y+P
Sbjct: 2464 KRTKGVYVP 2472
>XP_005256527
          Length = 4427

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+K +Y+P
Sbjct: 2464 KRTKGVYVP 2472
>NP_000284
          Length = 1093

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KRSKSIYMP 9
          KRS S+Y P
Sbjct: 23 KRSGSVYEP 31
>NP_689753
          Length = 684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRSKSIYMP 9
           K+ KS+Y+P
Sbjct: 555 KQFKSVYVP 563
>XP_005256040
          Length = 1093

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KRSKSIYMP 9
          KRS S+Y P
Sbjct: 23 KRSGSVYEP 31
>NP_000072
          Length = 3801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+KS+ +P
Sbjct: 1499 KRNKSLILP 1507
>NP_001166137
          Length = 262

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRSKSIYMP 9
           KRSKSI  P
Sbjct: 239 KRSKSIRPP 247
>NP_001166136
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRSKSIYMP 9
           KRSKSI  P
Sbjct: 258 KRSKSIRPP 266
>NP_001166135
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRSKSIYMP 9
           KRSKSI  P
Sbjct: 258 KRSKSIRPP 266
>NP_066991
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRSKSIYMP 9
           KRSKSI  P
Sbjct: 258 KRSKSIRPP 266
>NP_001166134
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRSKSIYMP 9
           KRSKSI  P
Sbjct: 258 KRSKSIRPP 266
>XP_006722488
          Length = 1084

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_006722487
          Length = 1102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_006722486
          Length = 1150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_006722485
          Length = 1168

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_005266720
          Length = 1234

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_006722484
          Length = 1252

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_005266717
          Length = 1254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_005266715
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KRSKSIYMP 9
          KRS S+++P
Sbjct: 67 KRSSSMFIP 75
>XP_005273087
          Length = 2788

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+KS+ +P
Sbjct: 1499 KRNKSLILP 1507
>XP_006711794
          Length = 3022

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KRSKSIYMP 9
           KR+KS+ +P
Sbjct: 720 KRNKSLILP 728
>XP_005273086
          Length = 3264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+KS+ +P
Sbjct: 1499 KRNKSLILP 1507
>XP_005273085
          Length = 3755

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+KS+ +P
Sbjct: 1499 KRNKSLILP 1507
>XP_005273084
          Length = 3801

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    KRSKSIYMP 9
            KR+KS+ +P
Sbjct: 1499 KRNKSLILP 1507
>NP_004817
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KRSKSIYM 8
           +RS+SIY+
Sbjct: 723 RRSQSIYL 730
>NP_001277716
          Length = 773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KRSKSIYM 8
           +RS+SIY+
Sbjct: 721 RRSQSIYL 728
>NP_073572
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RSKSIY 7
           RSKS+Y
Sbjct: 516 RSKSVY 521
>NP_055625
          Length = 3117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1276 ERSKSSVMP 1284
>NP_001073890
          Length = 1703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KRSKSIY 7
           KR+K+IY
Sbjct: 710 KRTKTIY 716
>XP_006722755
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KRSKSIY 7
           KR+K+IY
Sbjct: 710 KRTKTIY 716
>XP_006711734
          Length = 3136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1254 ERSKSSVMP 1262
>XP_006711733
          Length = 3137

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1255 ERSKSSVMP 1263
>XP_006711732
          Length = 3154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1272 ERSKSSVMP 1280
>XP_006711731
          Length = 3157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1275 ERSKSSVMP 1283
>XP_006711730
          Length = 3157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1275 ERSKSSVMP 1283
>XP_006711729
          Length = 3158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1276 ERSKSSVMP 1284
>XP_005245695
          Length = 3158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KRSKSIYMP 9
            +RSKS  MP
Sbjct: 1276 ERSKSSVMP 1284
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.126    0.349 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,164
Number of extensions: 684
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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