Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           21     175
NP_000170                                                              21     175
XP_005264328                                                           21     175
NP_001268422                                                           17    2528
NP_001268423                                                           17    2528
NP_002283                                                              17    2528
XP_005265184                                                           17    2528
NP_001276065                                                           17    3301
NP_004778                                                              17    3301
NP_001276064                                                           17    3301
NP_937870                                                              17    3301
NP_937872                                                              17    3301
XP_005248271                                                           17    3301
XP_006714049                                                           17    3301
XP_005248268                                                           17    3301
XP_006713970                                                           17    3301
XP_006713968                                                           17    3301
NP_002917                                                              17    3301
NP_776253                                                              17    4312
NP_003646                                                              17    4312
NP_001269836                                                           17    4312
NP_001269837                                                           17    4312
NP_001269838                                                           17    4312
NP_006576                                                              17    4312
XP_005245126                                                           17    4312
NP_001128206                                                           17    4312
NP_039224                                                              17    4312
NP_057336                                                              16    5631
NP_061181                                                              16    5631
NP_683692                                                              16    5631
NP_001184216                                                           16    5631
XP_005248208                                                           16    5631
XP_005248207                                                           16    5631
XP_006714021                                                           16    5631
XP_006712120                                                           16    5631
XP_005264512                                                           16    5631
XP_005264511                                                           16    5631
XP_006712119                                                           16    5631
XP_005264510                                                           16    5631
XP_006712118                                                           16    5631
XP_005264509                                                           16    5631
XP_005264508                                                           16    5631
XP_006712117                                                           16    5631
XP_005264507                                                           16    5631
XP_005264506                                                           16    5631
NP_001013372                                                           16    5631
NP_001005239                                                           16    5631
NP_001439                                                              16    7355
NP_060037                                                              16    7355
NP_001121902                                                           16    7355
NP_859075                                                              16    7355
NP_001121901                                                           16    7355
NP_055335                                                              16    7355
NP_001099008                                                           16    7355
NP_115818                                                              16    7355
NP_001005408                                                           16    7355
NP_064544                                                              16    7355
NP_001241878                                                           16    7355
XP_006721482                                                           16    7355
XP_005256470                                                           16    7355
XP_006719432                                                           16    7355
XP_006719431                                                           16    7355
XP_006714340                                                           16    7355
XP_006714339                                                           16    7355
XP_006714338                                                           16    7355
NP_001001392                                                           15    9605
NP_060876                                                              15    9605
NP_003363                                                              15    9605
NP_699188                                                              15    9605
XP_005256545                                                           15    9605
XP_005270979                                                           15    9605
NP_056972                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KRMVTGNGA 9
           KRMVTGNG+
Sbjct: 171 KRMVTGNGS 179
>NP_000170
          Length = 1360

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KRMVTGNGA 9
           KRMVTGNG+
Sbjct: 301 KRMVTGNGS 309
>XP_005264328
          Length = 1261

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KRMVTGNGA 9
           KRMVTGNG+
Sbjct: 202 KRMVTGNGS 210
>NP_001268422
          Length = 1058

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 MVTGNGA 9
         MVTGNG+
Sbjct: 1 MVTGNGS 7
>NP_001268423
          Length = 1058

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3 MVTGNGA 9
         MVTGNG+
Sbjct: 1 MVTGNGS 7
>NP_002283
          Length = 1798

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRMVTGNG 8
           KR+VTG G
Sbjct: 494 KRLVTGRG 501
>XP_005265184
          Length = 1798

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRMVTGNG 8
           KR+VTG G
Sbjct: 494 KRLVTGRG 501
>NP_001276065
          Length = 1521

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRMVTGN 7
           KR+VTGN
Sbjct: 674 KRIVTGN 680
>NP_004778
          Length = 1529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRMVTGN 7
           KR+VTGN
Sbjct: 682 KRIVTGN 688
>NP_001276064
          Length = 1525

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRMVTGN 7
           KR+VTGN
Sbjct: 678 KRIVTGN 684
>NP_937870
          Length = 799

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KRMVTGNG 8
           KR  TGNG
Sbjct: 595 KRSATGNG 602
>NP_937872
          Length = 1447

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    KRMVTGNG 8
            KR  TGNG
Sbjct: 1243 KRSATGNG 1250
>XP_005248271
          Length = 1404

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRMVTGN 7
           KR+VTGN
Sbjct: 557 KRIVTGN 563
>XP_006714049
          Length = 1509

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRMVTGN 7
           KR+VTGN
Sbjct: 686 KRIVTGN 692
>XP_005248268
          Length = 1533

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRMVTGN 7
           KR+VTGN
Sbjct: 686 KRIVTGN 692
>XP_006713970
          Length = 646

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KRMVTGNG 8
           KR  TGNG
Sbjct: 442 KRSATGNG 449
>XP_006713968
          Length = 1447

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    KRMVTGNG 8
            KR  TGNG
Sbjct: 1243 KRSATGNG 1250
>NP_002917
          Length = 1376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    KRMVTGNG 8
            KR  TGNG
Sbjct: 1243 KRSATGNG 1250
>NP_776253
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RMVTGNGA 9
           RM+TGN A
Sbjct: 174 RMITGNMA 181
>NP_003646
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KRMVTGNG 8
           K  VTGNG
Sbjct: 238 KEAVTGNG 245
>NP_001269836
          Length = 529

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRMVTGNGA 9
           KR+V G GA
Sbjct: 387 KRLVPGGGA 395
>NP_001269837
          Length = 497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRMVTGNGA 9
           KR+V G GA
Sbjct: 355 KRLVPGGGA 363
>NP_001269838
          Length = 475

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRMVTGNGA 9
           KR+V G GA
Sbjct: 333 KRLVPGGGA 341
>NP_006576
          Length = 548

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRMVTGNGA 9
           KR+V G GA
Sbjct: 406 KRLVPGGGA 414
>XP_005245126
          Length = 513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RMVTGNGA 9
           RM+TGN A
Sbjct: 174 RMITGNMA 181
>NP_001128206
          Length = 598

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KRMVTGNG 8
          +RM +GNG
Sbjct: 22 RRMASGNG 29
>NP_039224
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VTGNGA 9
          VTGNGA
Sbjct: 37 VTGNGA 42
>NP_057336
          Length = 4857

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>NP_061181
          Length = 548

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRMVTGNGA 9
           KR+ T NGA
Sbjct: 279 KRIATENGA 287
>NP_683692
          Length = 3051

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KRMVTGNG 8
            +RMVTG G
Sbjct: 1752 ERMVTGAG 1759
>NP_001184216
          Length = 326

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VTGNGA 9
          +TGNGA
Sbjct: 54 ITGNGA 59
>XP_005248208
          Length = 3097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KRMVTGNG 8
            +RMVTG G
Sbjct: 1752 ERMVTGAG 1759
>XP_005248207
          Length = 3098

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KRMVTGNG 8
            +RMVTG G
Sbjct: 1752 ERMVTGAG 1759
>XP_006714021
          Length = 3112

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KRMVTGNG 8
            +RMVTG G
Sbjct: 1752 ERMVTGAG 1759
>XP_006712120
          Length = 4812

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264512
          Length = 4840

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264511
          Length = 4847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_006712119
          Length = 4851

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264510
          Length = 4861

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_006712118
          Length = 4864

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264509
          Length = 4870

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264508
          Length = 4875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_006712117
          Length = 4878

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264507
          Length = 4880

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>XP_005264506
          Length = 4884

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3 MVTGNGA 9
         MVTG GA
Sbjct: 1 MVTGGGA 7
>NP_001013372
          Length = 326

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VTGNGA 9
          +TGNGA
Sbjct: 54 ITGNGA 59
>NP_001005239
          Length = 326

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  VTGNGA 9
          +TGNGA
Sbjct: 54 ITGNGA 59
>NP_001439
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KRMVTGNG 8
           +RM  GNG
Sbjct: 411 ERMAAGNG 418
>NP_060037
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RMVTGNGA 9
          R VTG+GA
Sbjct: 12 REVTGSGA 19
>NP_001121902
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 475 MLTGNG 480
>NP_859075
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RMVTGNGA 9
           RMV G GA
Sbjct: 198 RMVEGRGA 205
>NP_001121901
          Length = 1028

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 475 MLTGNG 480
>NP_055335
          Length = 1328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KRMVTGNG 8
          KR++TG G
Sbjct: 75 KRLITGLG 82
>NP_001099008
          Length = 1332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KRMVTGNG 8
          KR++TG G
Sbjct: 75 KRLITGLG 82
>NP_115818
          Length = 1562

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 608 MMTGNG 613
>NP_001005408
          Length = 1560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 608 MMTGNG 613
>NP_064544
          Length = 1026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 475 MLTGNG 480
>NP_001241878
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  MVTGNG 8
          M+TGNG
Sbjct: 45 MLTGNG 50
>XP_006721482
          Length = 723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KRMVTGNG 8
          KR++TG G
Sbjct: 75 KRLITGLG 82
>XP_005256470
          Length = 1120

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KRMVTGNG 8
          KR++TG G
Sbjct: 75 KRLITGLG 82
>XP_006719432
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RMVTGNGA 9
           RMV G GA
Sbjct: 198 RMVEGRGA 205
>XP_006719431
          Length = 283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   RMVTGNGA 9
           RMV G GA
Sbjct: 198 RMVEGRGA 205
>XP_006714340
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 475 MLTGNG 480
>XP_006714339
          Length = 795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 242 MLTGNG 247
>XP_006714338
          Length = 998

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   MVTGNG 8
           M+TGNG
Sbjct: 445 MLTGNG 450
>NP_001001392
          Length = 139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RMVTGNGA 9
           + V+GNGA
Sbjct: 116 QQVSGNGA 123
>NP_060876
          Length = 5412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   RMVTGN 7
           R+VTGN
Sbjct: 515 RLVTGN 520
>NP_003363
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 3  MVTGNG 8
          M TGNG
Sbjct: 13 MATGNG 18
>NP_699188
          Length = 471

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VTGNGA 9
           +TGNGA
Sbjct: 170 LTGNGA 175
>XP_005256545
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VTGNGA 9
           +TGNGA
Sbjct: 146 LTGNGA 151
>XP_005270979
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RMVTGNGA 9
           R+V+G GA
Sbjct: 684 RLVSGGGA 691
>NP_056972
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   RMVTGNGA 9
           R+V+G GA
Sbjct: 684 RLVSGGGA 691
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.128    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 699,271
Number of extensions: 2009
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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