Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_006222                                                              17    4312
NP_001257337                                                           17    4312
NP_067042                                                              17    4312
XP_006724850                                                           17    4312
XP_005262542                                                           17    4312
XP_006724100                                                           17    4312
XP_006719430                                                           17    4312
XP_006719429                                                           17    4312
XP_006719428                                                           17    4312
XP_005253933                                                           17    4312
NP_001084                                                              17    4312
NP_061147                                                              16    7355
NP_001172022                                                           16    7355
NP_001229322                                                           16    7355
NP_005591                                                              16    7355
NP_071325                                                              16    7355
NP_998778                                                              16    7355
NP_001172023                                                           16    7355
NP_001172021                                                           16    7355
XP_006723889                                                           16    7355
XP_006723888                                                           16    7355
XP_005260513                                                           16    7355
XP_005260512                                                           16    7355
XP_006713920                                                           16    7355
XP_006713919                                                           16    7355
XP_006711404                                                           16    7355
XP_005245273                                                           16    7355
XP_005245271                                                           16    7355
XP_005245272                                                           16    7355
NP_001070020                                                           16    7355

>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KRLGASVAF 9
            KRLGAS+AF
Sbjct: 1074 KRLGASLAF 1082



>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KRLGASVAF 9
            KRLGAS+AF
Sbjct: 1074 KRLGASLAF 1082



>NP_006222
          Length = 2286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRLGASVAF 9
            KRLG+SV +
Sbjct: 1857 KRLGSSVIY 1865



>NP_001257337
          Length = 312

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KRLGASVAF 9
          K+LG SV+F
Sbjct: 64 KKLGRSVSF 72



>NP_067042
          Length = 298

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KRLGASVAF 9
          K+LG SV+F
Sbjct: 64 KKLGRSVSF 72



>XP_006724850
          Length = 217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  RLGASVAF 9
          R+GA+VAF
Sbjct: 30 RVGAAVAF 37



>XP_005262542
          Length = 353

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  RLGASVAF 9
          R+GA+VAF
Sbjct: 30 RVGAAVAF 37



>XP_006724100
          Length = 305

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KRLGASVAF 9
          K+LG SV+F
Sbjct: 64 KKLGRSVSF 72



>XP_006719430
          Length = 2256

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRLGASVAF 9
            +R+GA VAF
Sbjct: 1162 QRMGAMVAF 1170



>XP_006719429
          Length = 2395

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRLGASVAF 9
            +R+GA VAF
Sbjct: 1301 QRMGAMVAF 1309



>XP_006719428
          Length = 2458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRLGASVAF 9
            +R+GA VAF
Sbjct: 1364 QRMGAMVAF 1372



>XP_005253933
          Length = 2458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRLGASVAF 9
            +R+GA VAF
Sbjct: 1364 QRMGAMVAF 1372



>NP_001084
          Length = 2458

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KRLGASVAF 9
            +R+GA VAF
Sbjct: 1364 QRMGAMVAF 1372



>NP_061147
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRLGASVAF 9
           K+LG  VAF
Sbjct: 115 KKLGDKVAF 123



>NP_001172022
          Length = 312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RLGASVAF 9
          RLGA +AF
Sbjct: 61 RLGACLAF 68



>NP_001229322
          Length = 606

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KRLGASVAF 9
          K+LG  VAF
Sbjct: 20 KKLGDKVAF 28



>NP_005591
          Length = 327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RLGASVAF 9
          RLGA +AF
Sbjct: 76 RLGACLAF 83



>NP_071325
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRLGASVA 8
           KR G+SVA
Sbjct: 313 KRFGSSVA 320



>NP_998778
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRLGASVA 8
           KR G+SVA
Sbjct: 313 KRFGSSVA 320



>NP_001172023
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RLGASVAF 9
          RLGA +AF
Sbjct: 40 RLGACLAF 47



>NP_001172021
          Length = 243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RLGASVAF 9
          RLGA +AF
Sbjct: 76 RLGACLAF 83



>XP_006723889
          Length = 629

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KRLGASVAF 9
          K+LG  VAF
Sbjct: 20 KKLGDKVAF 28



>XP_006723888
          Length = 665

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRLGASVAF 9
           K+LG  VAF
Sbjct: 115 KKLGDKVAF 123



>XP_005260513
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRLGASVAF 9
           K+LG  VAF
Sbjct: 115 KKLGDKVAF 123



>XP_005260512
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRLGASVAF 9
           K+LG  VAF
Sbjct: 115 KKLGDKVAF 123



>XP_006713920
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRLGASVA 8
           KR G+SVA
Sbjct: 313 KRFGSSVA 320



>XP_006713919
          Length = 701

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KRLGASVA 8
           KR G+SVA
Sbjct: 313 KRFGSSVA 320



>XP_006711404
          Length = 260

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLGASVAF 9
           RLGA +AF
Sbjct: 93  RLGACLAF 100



>XP_005245273
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RLGASVAF 9
          RLGA +AF
Sbjct: 40 RLGACLAF 47



>XP_005245271
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLGASVAF 9
           RLGA +AF
Sbjct: 93  RLGACLAF 100



>XP_005245272
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RLGASVAF 9
           RLGA +AF
Sbjct: 93  RLGACLAF 100



>NP_001070020
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRLGASVAF 9
           K+LG  VAF
Sbjct: 115 KKLGDKVAF 123



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.329    0.136    0.363 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 358,994
Number of extensions: 467
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)