Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           19     665
NP_036462                                                              19     665
NP_001243397                                                           19     665
XP_005269721                                                           19     665
NP_003048                                                              17    2528
NP_694857                                                              17    2528
XP_006726853                                                           17    2528
XP_006723596                                                           17    2528
XP_005267162                                                           17    2528
XP_005267161                                                           17    2528
XP_006715615                                                           17    2528
XP_005267160                                                           17    2528
XP_005267159                                                           17    2528
XP_006710111                                                           17    2528
NP_079366                                                              17    3301
XP_005257601                                                           17    3301
XP_005257599                                                           17    3301
XP_005257600                                                           17    3301
NP_001027462                                                           17    4312
NP_116025                                                              17    4312
NP_001005290                                                           17    4312
XP_006711048                                                           17    4312
XP_005271340                                                           17    4312
XP_006711047                                                           17    4312
XP_006711046                                                           17    4312
XP_006711045                                                           17    4312
XP_005271339                                                           17    4312
NP_056507                                                              17    4312
NP_060959                                                              16    5631
XP_005245393                                                           16    5631
XP_006711515                                                           16    5631
XP_006711514                                                           16    5631
XP_006711513                                                           16    5631
NP_001119516                                                           16    7355
NP_942012                                                              16    7355
NP_942008                                                              16    7355
NP_942007                                                              16    7355
NP_942009                                                              16    7355
NP_942011                                                              16    7355
NP_942010                                                              16    7355
NP_115689                                                              16    7355
NP_001269212                                                           16    7355
NP_542179                                                              16    7355
NP_006582                                                              16    7355
NP_001075042                                                           16    7355
XP_006724869                                                           16    7355
XP_006724868                                                           16    7355
XP_005274706                                                           16    7355
XP_005274705                                                           16    7355
XP_006724867                                                           16    7355
XP_005273773                                                           16    7355
XP_006713056                                                           16    7355
XP_005264949                                                           16    7355
XP_006712357                                                           16    7355
XP_006712356                                                           16    7355
XP_006712355                                                           16    7355
XP_006710345                                                           16    7355
XP_006710344                                                           16    7355
XP_006710343                                                           16    7355
XP_006710342                                                           16    7355
NP_006305                                                              16    7355
NP_001035522                                                           16    7355
NP_001010893                                                           16    7355
NP_001230913                                                           15    9605
NP_068810                                                              15    9605
NP_001138610                                                           15    9605
NP_001230914                                                           15    9605
NP_001032903                                                           15    9605
NP_001009                                                              15    9605
>NP_001243398
          Length = 1781

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KRKRTFVLK 9
           KRKR FVLK
Sbjct: 830 KRKRPFVLK 838
>NP_036462
          Length = 2073

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KRKRTFVLK 9
            KRKR FVLK
Sbjct: 1122 KRKRPFVLK 1130
>NP_001243397
          Length = 1890

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KRKRTFVLK 9
           KRKR FVLK
Sbjct: 939 KRKRPFVLK 947
>XP_005269721
          Length = 2073

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KRKRTFVLK 9
            KRKR FVLK
Sbjct: 1122 KRKRPFVLK 1130
>NP_003048
          Length = 554

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 344 RKRTFIL 350
>NP_694857
          Length = 506

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 344 RKRTFIL 350
>XP_006726853
          Length = 707

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KRKRTFVLK 9
           KR+RTFV K
Sbjct: 223 KRQRTFVEK 231
>XP_006723596
          Length = 707

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KRKRTFVLK 9
           KR+RTFV K
Sbjct: 223 KRQRTFVEK 231
>XP_005267162
          Length = 418

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 152 RKRTFIL 158
>XP_005267161
          Length = 418

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 152 RKRTFIL 158
>XP_006715615
          Length = 483

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 344 RKRTFIL 350
>XP_005267160
          Length = 573

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 344 RKRTFIL 350
>XP_005267159
          Length = 610

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   RKRTFVL 8
           RKRTF+L
Sbjct: 344 RKRTFIL 350
>XP_006710111
          Length = 566

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KRKRTFVLK 9
          KR+RTFV K
Sbjct: 82 KRQRTFVEK 90
>NP_079366
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRKRTFV 7
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>XP_005257601
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRKRTFV 7
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>XP_005257599
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRKRTFV 7
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>XP_005257600
          Length = 1123

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KRKRTFV 7
           KRK+TFV
Sbjct: 811 KRKKTFV 817
>NP_001027462
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>NP_116025
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>NP_001005290
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>XP_006711048
          Length = 310

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>XP_005271340
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>XP_006711047
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>XP_006711046
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>XP_006711045
          Length = 333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>XP_005271339
          Length = 363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+ TFVLK
Sbjct: 113 RRETFVLK 120
>NP_056507
          Length = 1932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KRKRTF 6
           KRKRTF
Sbjct: 788 KRKRTF 793
>NP_060959
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RKRTFVLK 9
            R+R FVLK
Sbjct: 2350 RERNFVLK 2357
>XP_005245393
          Length = 2663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RKRTFVLK 9
            R+R FVLK
Sbjct: 2350 RERNFVLK 2357
>XP_006711515
          Length = 2904

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RKRTFVLK 9
            R+R FVLK
Sbjct: 2290 RERNFVLK 2297
>XP_006711514
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RKRTFVLK 9
            R+R FVLK
Sbjct: 2350 RERNFVLK 2357
>XP_006711513
          Length = 2964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    RKRTFVLK 9
            R+R FVLK
Sbjct: 2350 RERNFVLK 2357
>NP_001119516
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_942012
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_942008
          Length = 388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_942007
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_942009
          Length = 374

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_942011
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_942010
          Length = 365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KRKRTFVL 8
          KRK++F+L
Sbjct: 83 KRKKSFLL 90
>NP_115689
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTFVLK 9
           RTFVLK
Sbjct: 527 RTFVLK 532
>NP_001269212
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 27 RKRWFVLR 34
>NP_542179
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 27 RKRWFVLR 34
>NP_006582
          Length = 466

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRKRTFVLK 9
           KRKR  VLK
Sbjct: 380 KRKRKRVLK 388
>NP_001075042
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 27 RKRWFVLR 34
>XP_006724869
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 27 RKRWFVLR 34
>XP_006724868
          Length = 564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 5  RKRWFVLR 12
>XP_005274706
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 5  RKRWFVLR 12
>XP_005274705
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 27 RKRWFVLR 34
>XP_006724867
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR FVL+
Sbjct: 27 RKRWFVLR 34
>XP_005273773
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KRKRTFVLK 9
           KRKR  VLK
Sbjct: 380 KRKRKRVLK 388
>XP_006713056
          Length = 384

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRKRTFVLK 9
           KRKR  +LK
Sbjct: 264 KRKRKAILK 272
>XP_005264949
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRKRTFVLK 9
           KRKR  +LK
Sbjct: 319 KRKRKAILK 327
>XP_006712357
          Length = 252

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RKRTFVLK 9
           +K+TFVL+
Sbjct: 183 KKKTFVLQ 190
>XP_006712356
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RKRTFVLK 9
           +K+TFVL+
Sbjct: 182 KKKTFVLQ 189
>XP_006712355
          Length = 304

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   RKRTFVLK 9
           +K+TFVL+
Sbjct: 183 KKKTFVLQ 190
>XP_006710345
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+R FVLK
Sbjct: 160 RRRWFVLK 167
>XP_006710344
          Length = 720

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+R FVLK
Sbjct: 425 RRRWFVLK 432
>XP_006710343
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+R FVLK
Sbjct: 459 RRRWFVLK 466
>XP_006710342
          Length = 761

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+R FVLK
Sbjct: 466 RRRWFVLK 473
>NP_006305
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   RKRTFVLK 9
           R+R FVLK
Sbjct: 418 RRRWFVLK 425
>NP_001035522
          Length = 356

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KRKRTFVLK 9
           KRKR  +LK
Sbjct: 236 KRKRKAILK 244
>NP_001010893
          Length = 438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KRKRTFVL 8
           KRKR F++
Sbjct: 431 KRKRNFLI 438
>NP_001230913
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KRKRTF 6
           KRKRT+
Sbjct: 301 KRKRTY 306
>NP_068810
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KRKRTF 6
           KRKRT+
Sbjct: 301 KRKRTY 306
>NP_001138610
          Length = 548

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KRKRTF 6
           KRKRT+
Sbjct: 298 KRKRTY 303
>NP_001230914
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KRKRTF 6
           KRKRT+
Sbjct: 301 KRKRTY 306
>NP_001032903
          Length = 574

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  RKRTFVLK 9
          RKR F+L+
Sbjct: 61 RKRWFILR 68
>NP_001009
          Length = 145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KRKRTF 6
          K+KRTF
Sbjct: 7  KKKRTF 12
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.143    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 484,112
Number of extensions: 925
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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