Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              18    1482
NP_001087241                                                           18    1482
XP_005265799                                                           18    1482
XP_005265798                                                           18    1482
XP_005265797                                                           18    1482
NP_060839                                                              17    3301
NP_001138680                                                           17    3301
NP_001160022                                                           17    4312
NP_000193                                                              17    4312
NP_006114                                                              17    4312
NP_003817                                                              16    5631
NP_001002912                                                           15    9605
NP_002968                                                              15    9605
NP_003038                                                              15    9605
NP_005779                                                              15    9605
NP_001138639                                                           15    9605
NP_001138638                                                           15    9605
XP_006718184                                                           15    9605
XP_005252787                                                           15    9605
XP_005246814                                                           15    9605
XP_005270507                                                           15    9605
XP_006710414                                                           15    9605
XP_006710413                                                           15    9605
XP_006710412                                                           15    9605
XP_006710411                                                           15    9605
>NP_000213
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ VQLIEK
Sbjct: 918 KQIVQLIEK 926
>NP_001087241
          Length = 972

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ VQLIEK
Sbjct: 914 KQIVQLIEK 922
>XP_005265799
          Length = 973

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ VQLIEK
Sbjct: 915 KQIVQLIEK 923
>XP_005265798
          Length = 976

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ VQLIEK
Sbjct: 918 KQIVQLIEK 926
>XP_005265797
          Length = 977

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ VQLIEK
Sbjct: 919 KQIVQLIEK 927
>NP_060839
          Length = 529

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KQSVQLIEK 9
          KQ+VQL++K
Sbjct: 70 KQTVQLLKK 78
>NP_001138680
          Length = 467

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1  KQSVQLIEK 9
          KQ+VQL++K
Sbjct: 70 KQTVQLLKK 78
>NP_001160022
          Length = 460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQSVQLIEK 9
           +Q++QL+EK
Sbjct: 113 EQAIQLLEK 121
>NP_000193
          Length = 550

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQSVQLIEK 9
           +Q++QL+EK
Sbjct: 203 EQAIQLLEK 211
>NP_006114
          Length = 343

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KQSVQLIEK 9
           +Q++QL+EK
Sbjct: 203 EQAIQLLEK 211
>NP_003817
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QSVQLIEK 9
           ++VQLIEK
Sbjct: 93  EAVQLIEK 100
>NP_001002912
          Length = 1530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           K+S QL++K
Sbjct: 757 KESQQLVQK 765
>NP_002968
          Length = 1977

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KQSVQLIEK 9
          KQS+ LIE+
Sbjct: 17 KQSLALIEQ 25
>NP_003038
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KQSVQLIE 8
           KQ+++L+E
Sbjct: 583 KQAIELVE 590
>NP_005779
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ+V L+EK
Sbjct: 481 KQTVFLLEK 489
>NP_001138639
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ+V L+EK
Sbjct: 404 KQTVFLLEK 412
>NP_001138638
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ+V L+EK
Sbjct: 419 KQTVFLLEK 427
>XP_006718184
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ+V L+EK
Sbjct: 317 KQTVFLLEK 325
>XP_005252787
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           KQ+V L+EK
Sbjct: 448 KQTVFLLEK 456
>XP_005246814
          Length = 1988

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KQSVQLIEK 9
          KQS+ LIE+
Sbjct: 17 KQSLALIEQ 25
>XP_005270507
          Length = 788

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KQSVQLIEK 9
          K+S QL++K
Sbjct: 15 KESQQLVQK 23
>XP_006710414
          Length = 834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KQSVQLIEK 9
          K+S QL++K
Sbjct: 61 KESQQLVQK 69
>XP_006710413
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KQSVQLIEK 9
          K+S QL++K
Sbjct: 75 KESQQLVQK 83
>XP_006710412
          Length = 1333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           K+S QL++K
Sbjct: 560 KESQQLVQK 568
>XP_006710411
          Length = 1528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQSVQLIEK 9
           K+S QL++K
Sbjct: 755 KESQQLVQK 763
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.121    0.265 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 311,367
Number of extensions: 478
Number of successful extensions: 25
Number of sequences better than 10000.0: 25
Number of HSP's gapped: 25
Number of HSP's successfully gapped: 25
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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