Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_060141                                                              18    1482
NP_008835                                                              17    2528
NP_001075109                                                           17    2528
NP_000570                                                              16    5631
NP_001093638                                                           16    5631
NP_004696                                                              16    5631
NP_872381                                                              16    5631
XP_005258854                                                           16    5631
XP_005258855                                                           16    5631
XP_005258852                                                           16    5631
XP_005258850                                                           16    5631
XP_005258848                                                           16    5631
XP_005272158                                                           16    5631
NP_114158                                                              16    5631
NP_848537                                                              16    7355
NP_113659                                                              16    7355
NP_006823                                                              16    7355
NP_001271203                                                           16    7355
NP_877497                                                              16    7355
XP_005267342                                                           16    7355
XP_006718768                                                           16    7355
XP_006718767                                                           16    7355
XP_006718766                                                           16    7355
XP_005269612                                                           16    7355
NP_001005178                                                           16    7355
NP_001128302                                                           15    9605
NP_060121                                                              15    9605
NP_001128303                                                           15    9605
NP_001128304                                                           15    9605
NP_005021                                                              15    9605
NP_001120965                                                           15    9605
NP_066187                                                              15    9605
NP_001139                                                              15    9605
NP_001257936                                                           15    9605
NP_001257935                                                           15    9605
NP_659435                                                              15    9605
XP_005256396                                                           15    9605
XP_005267096                                                           15    9605
XP_006715570                                                           15    9605
XP_006714257                                                           15    9605
XP_006714256                                                           15    9605
XP_006714255                                                           15    9605
XP_005263005                                                           15    9605
XP_006714254                                                           15    9605
XP_006714253                                                           15    9605
XP_005263002                                                           15    9605
XP_005262999                                                           15    9605
XP_006714252                                                           15    9605
XP_006714251                                                           15    9605
XP_006714250                                                           15    9605
>NP_060141
          Length = 677

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KQLASRLLE 9
           KQLA+R+LE
Sbjct: 530 KQLAARILE 538
>NP_008835
          Length = 4128

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KQLASRLLE 9
            KQLAS LLE
Sbjct: 1508 KQLASGLLE 1516
>NP_001075109
          Length = 4097

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KQLASRLLE 9
            KQLAS LLE
Sbjct: 1508 KQLASGLLE 1516
>NP_000570
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  KQLASRLL 8
          KQ+A+RLL
Sbjct: 26 KQIAARLL 33
>NP_001093638
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  KQLASRLL 8
          KQ+A+RLL
Sbjct: 26 KQIAARLL 33
>NP_004696
          Length = 761

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KQLASRLLE 9
           K +ASRLLE
Sbjct: 341 KVVASRLLE 349
>NP_872381
          Length = 350

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KQLASRLL 8
           K LASRLL
Sbjct: 287 KMLASRLL 294
>XP_005258854
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KQLASRLL 8
           K LASRLL
Sbjct: 174 KMLASRLL 181
>XP_005258855
          Length = 237

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KQLASRLL 8
           K LASRLL
Sbjct: 174 KMLASRLL 181
>XP_005258852
          Length = 320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KQLASRLL 8
           K LASRLL
Sbjct: 257 KMLASRLL 264
>XP_005258850
          Length = 376

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KQLASRLL 8
           K LASRLL
Sbjct: 313 KMLASRLL 320
>XP_005258848
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KQLASRLL 8
           K LASRLL
Sbjct: 320 KMLASRLL 327
>XP_005272158
          Length = 135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QLASRLLE 9
           QLA RLLE
Sbjct: 96  QLACRLLE 103
>NP_114158
          Length = 254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   QLASRLLE 9
           QLA RLLE
Sbjct: 96  QLACRLLE 103
>NP_848537
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  R+LE
Sbjct: 518 KQLTPRILE 526
>NP_113659
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  R+LE
Sbjct: 514 KQLTPRILE 522
>NP_006823
          Length = 680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQLASRLLE 9
           KQ+ +R+LE
Sbjct: 533 KQITARILE 541
>NP_001271203
          Length = 780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  RLL+
Sbjct: 285 KQLVERLLQ 293
>NP_877497
          Length = 776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  RLL+
Sbjct: 281 KQLVERLLQ 289
>XP_005267342
          Length = 691

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQLASRLLE 9
           KQ+ +R+LE
Sbjct: 544 KQITARILE 552
>XP_006718768
          Length = 483

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  R+LE
Sbjct: 334 KQLTPRILE 342
>XP_006718767
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  R+LE
Sbjct: 467 KQLTPRILE 475
>XP_006718766
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  R+LE
Sbjct: 514 KQLTPRILE 522
>XP_005269612
          Length = 669

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL  RLL+
Sbjct: 174 KQLVERLLQ 182
>NP_001005178
          Length = 320

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQ+  RLLE
Sbjct: 303 KQIRDRLLE 311
>NP_001128302
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL SRL E
Sbjct: 411 KQLKSRLPE 419
>NP_060121
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL SRL E
Sbjct: 411 KQLKSRLPE 419
>NP_001128303
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL SRL E
Sbjct: 411 KQLKSRLPE 419
>NP_001128304
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL SRL E
Sbjct: 411 KQLKSRLPE 419
>NP_005021
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KQLASRL 7
           K+LASRL
Sbjct: 574 KELASRL 580
>NP_001120965
          Length = 1863

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1017 LASRLIE 1023
>NP_066187
          Length = 1872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1026 LASRLIE 1032
>NP_001139
          Length = 3957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1026 LASRLIE 1032
>NP_001257936
          Length = 58

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KQLASRLL 8
          K+L SRLL
Sbjct: 12 KELVSRLL 19
>NP_001257935
          Length = 81

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KQLASRLL 8
          K+L SRLL
Sbjct: 12 KELVSRLL 19
>NP_659435
          Length = 63

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KQLASRLL 8
          K+L SRLL
Sbjct: 12 KELVSRLL 19
>XP_005256396
          Length = 131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KQLASRLL 8
          K+L SRLL
Sbjct: 12 KELVSRLL 19
>XP_005267096
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL SRL E
Sbjct: 411 KQLKSRLPE 419
>XP_006715570
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KQLASRLLE 9
           KQL SRL E
Sbjct: 411 KQLKSRLPE 419
>XP_006714257
          Length = 4145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1068 LASRLIE 1074
>XP_006714256
          Length = 1901

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1088 LASRLIE 1094
>XP_006714255
          Length = 1970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1076 LASRLIE 1082
>XP_005263005
          Length = 2019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1058 LASRLIE 1064
>XP_006714254
          Length = 2049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1088 LASRLIE 1094
>XP_006714253
          Length = 2069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1088 LASRLIE 1094
>XP_005263002
          Length = 4072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1026 LASRLIE 1032
>XP_005262999
          Length = 4147

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1070 LASRLIE 1076
>XP_006714252
          Length = 4153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1076 LASRLIE 1082
>XP_006714251
          Length = 4165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1088 LASRLIE 1094
>XP_006714250
          Length = 4190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LASRLLE 9
            LASRL+E
Sbjct: 1080 LASRLIE 1086
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.128    0.290 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 304,365
Number of extensions: 518
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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