Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              18    1135
XP_005266703                                                           18    1135
NP_005465                                                              17    2528
NP_001015053                                                           17    2528
XP_006721692                                                           17    2528
XP_005256964                                                           17    2528
XP_005256963                                                           17    2528
XP_005256962                                                           17    2528
XP_005256961                                                           17    2528
NP_005076                                                              17    3301
NP_000740                                                              17    3301
XP_005272276                                                           17    3301
XP_005272275                                                           17    3301
XP_006717355                                                           17    3301
XP_005272274                                                           17    3301
XP_005272273                                                           17    3301
NP_597677                                                              17    4312
NP_056199                                                              17    4312
XP_005248339                                                           17    4312
XP_005248337                                                           17    4312
XP_006714531                                                           17    4312
XP_006714530                                                           17    4312
NP_997320                                                              16    7355
NP_004781                                                              16    7355
NP_695008                                                              16    7355
NP_695010                                                              16    7355
NP_695009                                                              16    7355
NP_037517                                                              16    7355
NP_060269                                                              16    7355
XP_006720240                                                           16    7355
XP_006720238                                                           16    7355
XP_005253612                                                           16    7355
XP_006718456                                                           16    7355
XP_003846701                                                           16    7355
NP_694948                                                              16    7355
NP_001230280                                                           15    9605
NP_057202                                                              15    9605
NP_054730                                                              15    9605
XP_006720705                                                           15    9605
XP_005250069                                                           15    9605
XP_005250068                                                           15    9605
XP_005250067                                                           15    9605
NP_001123920                                                           15    9605
NP_001094874                                                           15    9605
NP_659198                                                              15    9605
>NP_443179
          Length = 2170

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KQKQLSIGK 9
            KQKQ SIGK
Sbjct: 2139 KQKQPSIGK 2147
>XP_005266703
          Length = 1501

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KQKQLSIGK 9
            KQKQ SIGK
Sbjct: 1470 KQKQPSIGK 1478
>NP_005465
          Length = 1122

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 525 KQQQLQLGK 533
>NP_001015053
          Length = 1123

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 526 KQQQLQLGK 534
>XP_006721692
          Length = 1081

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 484 KQQQLQLGK 492
>XP_005256964
          Length = 1118

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 521 KQQQLQLGK 529
>XP_005256963
          Length = 1122

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 525 KQQQLQLGK 533
>XP_005256962
          Length = 1122

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 525 KQQQLQLGK 533
>XP_005256961
          Length = 1123

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQ+QL +GK
Sbjct: 526 KQQQLQLGK 534
>NP_005076
          Length = 2090

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           K KQL++GK
Sbjct: 203 KGKQLAVGK 211
>NP_000740
          Length = 458

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQKQLS G+
Sbjct: 377 KQKQLSDGE 385
>XP_005272276
          Length = 2036

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           K KQL++GK
Sbjct: 244 KGKQLAVGK 252
>XP_005272275
          Length = 2083

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           K KQL++GK
Sbjct: 244 KGKQLAVGK 252
>XP_006717355
          Length = 2120

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           K KQL++GK
Sbjct: 244 KGKQLAVGK 252
>XP_005272274
          Length = 2121

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           K KQL++GK
Sbjct: 244 KGKQLAVGK 252
>XP_005272273
          Length = 2132

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           K KQL++GK
Sbjct: 244 KGKQLAVGK 252
>NP_597677
          Length = 2804

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQK++ +GK
Sbjct: 325 KQKKMKLGK 333
>NP_056199
          Length = 2697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQK++ +GK
Sbjct: 325 KQKKMKLGK 333
>XP_005248339
          Length = 2584

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQK++ +GK
Sbjct: 105 KQKKMKLGK 113
>XP_005248337
          Length = 2698

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQK++ +GK
Sbjct: 325 KQKKMKLGK 333
>XP_006714531
          Length = 2738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQK++ +GK
Sbjct: 325 KQKKMKLGK 333
>XP_006714530
          Length = 2755

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KQKQLSIGK 9
           KQK++ +GK
Sbjct: 325 KQKKMKLGK 333
>NP_997320
          Length = 4471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KQKQLSIGK 9
           KQK L +G+
Sbjct: 605 KQKYLEVGR 613
>NP_004781
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKQLSIGK 9
           QK+L++GK
Sbjct: 314 QKELTMGK 321
>NP_695008
          Length = 550

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKQLSIGK 9
           QK+L++GK
Sbjct: 314 QKELTMGK 321
>NP_695010
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKQLSIGK 9
           QK+L++GK
Sbjct: 314 QKELTMGK 321
>NP_695009
          Length = 506

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QKQLSIGK 9
           QK+L++GK
Sbjct: 314 QKELTMGK 321
>NP_037517
          Length = 394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KQKQLSIGK 9
          K+K+L IG+
Sbjct: 61 KEKELCIGR 69
>NP_060269
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQKQLSIG 8
           K+K+LS+G
Sbjct: 210 KKKELSLG 217
>XP_006720240
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQKQLSIG 8
           K+K+LS+G
Sbjct: 210 KKKELSLG 217
>XP_006720238
          Length = 597

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQKQLSIG 8
           K+K+LS+G
Sbjct: 210 KKKELSLG 217
>XP_005253612
          Length = 4589

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KQKQLSIGK 9
           KQK L +G+
Sbjct: 723 KQKYLEVGR 731
>XP_006718456
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   KQLSIGK 9
           KQL++GK
Sbjct: 737 KQLTVGK 743
>XP_003846701
          Length = 143

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KQKQLSIGK 9
           K  QLS+GK
Sbjct: 128 KGTQLSVGK 136
>NP_694948
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KQKQLSIG 8
           +QK+LS+G
Sbjct: 134 RQKRLSLG 141
>NP_001230280
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKQLSIGK 9
           +KQL +GK
Sbjct: 157 KKQLQLGK 164
>NP_057202
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKQLSIGK 9
           +KQL +GK
Sbjct: 157 KKQLQLGK 164
>NP_054730
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KQKQLSIG 8
          K+K +SIG
Sbjct: 41 KEKNISIG 48
>XP_006720705
          Length = 508

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KQLSIGK 9
          KQLS+G+
Sbjct: 6  KQLSLGR 12
>XP_005250069
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKQLSIGK 9
           +KQL +GK
Sbjct: 157 KKQLQLGK 164
>XP_005250068
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKQLSIGK 9
           +KQL +GK
Sbjct: 133 KKQLQLGK 140
>XP_005250067
          Length = 638

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QKQLSIGK 9
           +KQL +GK
Sbjct: 157 KKQLQLGK 164
>NP_001123920
          Length = 175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KQLSIGK 9
          KQLS+G+
Sbjct: 16 KQLSLGR 22
>NP_001094874
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  KQLSIGK 9
          KQLS+G+
Sbjct: 6  KQLSLGR 12
>NP_659198
          Length = 536

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KQKQLSIG 8
          K+K +SIG
Sbjct: 41 KEKNISIG 48
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.304    0.124    0.298 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 494,410
Number of extensions: 598
Number of successful extensions: 45
Number of sequences better than 10000.0: 45
Number of HSP's gapped: 45
Number of HSP's successfully gapped: 45
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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