Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           20     509
NP_036462                                                              20     509
NP_001243397                                                           20     509
NP_859526                                                              20     509
NP_002543                                                              20     509
NP_001177810                                                           20     509
NP_001177808                                                           20     509
NP_001177811                                                           20     509
NP_859525                                                              20     509
XP_005269721                                                           20     509
XP_006712619                                                           20     509
NP_001017969                                                           18    1482
XP_006716793                                                           18    1482
XP_005251442                                                           18    1482
NP_056355                                                              17    4312
XP_006720533                                                           17    4312
XP_006720532                                                           17    4312
XP_005254354                                                           17    4312
NP_775762                                                              17    4312
NP_001366                                                              16    5631
NP_683701                                                              16    7355
NP_001139                                                              16    7355
XP_003960376                                                           16    7355
XP_006716052                                                           16    7355
XP_006716051                                                           16    7355
XP_006714257                                                           16    7355
XP_005263002                                                           16    7355
XP_005262999                                                           16    7355
XP_006714252                                                           16    7355
XP_006714251                                                           16    7355
XP_006714250                                                           16    7355
XP_003403558                                                           16    7355
XP_006710844                                                           16    7355
XP_003846715                                                           16    7355
NP_000950                                                              16    7355
NP_001034674                                                           16    7355
NP_006827                                                              15    9605
NP_001013682                                                           15    9605
XP_005270918                                                           15    9605
>NP_001243398
          Length = 1781

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KPVLMKAFQ 9
           KPVL KAFQ
Sbjct: 894 KPVLRKAFQ 902
>NP_036462
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPVLMKAFQ 9
            KPVL KAFQ
Sbjct: 1186 KPVLRKAFQ 1194
>NP_001243397
          Length = 1890

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPVLMKAFQ 9
            KPVL KAFQ
Sbjct: 1003 KPVLRKAFQ 1011
>NP_859526
          Length = 436

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 369 KPVVMKAFE 377
>NP_002543
          Length = 436

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 369 KPVVMKAFE 377
>NP_001177810
          Length = 352

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 285 KPVVMKAFE 293
>NP_001177808
          Length = 436

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 369 KPVVMKAFE 377
>NP_001177811
          Length = 362

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 295 KPVVMKAFE 303
>NP_859525
          Length = 436

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 369 KPVVMKAFE 377
>XP_005269721
          Length = 2073

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPVLMKAFQ 9
            KPVL KAFQ
Sbjct: 1186 KPVLRKAFQ 1194
>XP_006712619
          Length = 352

 Score = 19.6 bits (39), Expect =   509
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   KPVLMKAFQ 9
           KPV+MKAF+
Sbjct: 285 KPVVMKAFE 293
>NP_001017969
          Length = 2103

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KPVLMKAFQ 9
           +P LMKAFQ
Sbjct: 822 EPKLMKAFQ 830
>XP_006716793
          Length = 1317

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KPVLMKAFQ 9
          +P LMKAFQ
Sbjct: 36 EPKLMKAFQ 44
>XP_005251442
          Length = 2073

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KPVLMKAFQ 9
           +P LMKAFQ
Sbjct: 792 EPKLMKAFQ 800
>NP_056355
          Length = 1393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PVLMKAFQ 9
           PVLM+A Q
Sbjct: 696 PVLMRALQ 703
>XP_006720533
          Length = 1098

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PVLMKAFQ 9
           PVLM+A Q
Sbjct: 401 PVLMRALQ 408
>XP_006720532
          Length = 1333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PVLMKAFQ 9
           PVLM+A Q
Sbjct: 636 PVLMRALQ 643
>XP_005254354
          Length = 1393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   PVLMKAFQ 9
           PVLM+A Q
Sbjct: 696 PVLMRALQ 703
>NP_775762
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KPVLMKAFQ 9
           KPVL KA++
Sbjct: 207 KPVLGKAYE 215
>NP_001366
          Length = 360

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   PVLMKAFQ 9
           P L KAFQ
Sbjct: 331 PALWKAFQ 338
>NP_683701
          Length = 409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KPVLMKAF 8
           KPV+ K F
Sbjct: 381 KPVIFKVF 388
>NP_001139
          Length = 3957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 1993 LMKAFQ 1998
>XP_003960376
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPVLMKAFQ 9
           +P L+ AFQ
Sbjct: 138 RPTLLAAFQ 146
>XP_006716052
          Length = 1409

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  KPVLMKA 7
          KP++MKA
Sbjct: 16 KPLIMKA 22
>XP_006716051
          Length = 1427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  KPVLMKA 7
          KP++MKA
Sbjct: 16 KPLIMKA 22
>XP_006714257
          Length = 4145

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 2002 LMKAFQ 2007
>XP_005263002
          Length = 4072

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 1960 LMKAFQ 1965
>XP_005262999
          Length = 4147

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 2004 LMKAFQ 2009
>XP_006714252
          Length = 4153

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 2010 LMKAFQ 2015
>XP_006714251
          Length = 4165

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 2022 LMKAFQ 2027
>XP_006714250
          Length = 4190

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    LMKAFQ 9
            LMKAFQ
Sbjct: 2047 LMKAFQ 2052
>XP_003403558
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPVLMKAFQ 9
           +P L+ AFQ
Sbjct: 138 RPTLLAAFQ 146
>XP_006710844
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VLMKAFQ 9
          +LMKA+Q
Sbjct: 50 ILMKAYQ 56
>XP_003846715
          Length = 196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPVLMKAFQ 9
           +P L+ AFQ
Sbjct: 138 RPTLLAAFQ 146
>NP_000950
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VLMKAFQ 9
          +LMKA+Q
Sbjct: 50 ILMKAYQ 56
>NP_001034674
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VLMKAFQ 9
          +LMKA+Q
Sbjct: 50 ILMKAYQ 56
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    PVLMKAFQ 9
            P++ +AFQ
Sbjct: 1618 PIVQRAFQ 1625
>NP_001013682
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KPVLMKAF 8
           KPV  KAF
Sbjct: 396 KPVWSKAF 403
>XP_005270918
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KPVLMKAF 8
           KPV  KAF
Sbjct: 396 KPVWSKAF 403
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.137    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 482,386
Number of extensions: 720
Number of successful extensions: 39
Number of sequences better than 10000.0: 39
Number of HSP's gapped: 39
Number of HSP's successfully gapped: 39
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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