Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001186551                                                           18    1935
NP_001243070                                                           17    3301
NP_003045                                                              17    4312
NP_065734                                                              16    5631
NP_001075445                                                           16    5631
NP_849194                                                              16    5631
NP_056211                                                              16    5631
NP_001269271                                                           16    5631
NP_001160006                                                           16    5631
NP_001160005                                                           16    5631
NP_001253970                                                           16    5631
NP_006707                                                              16    5631
NP_001253971                                                           16    5631
XP_006719294                                                           16    5631
XP_005250179                                                           16    5631
XP_005250177                                                           16    5631
XP_005248604                                                           16    5631
XP_005248602                                                           16    5631
XP_006713630                                                           16    5631
XP_006713629                                                           16    5631
XP_006713628                                                           16    5631
XP_006713627                                                           16    5631
XP_005270547                                                           16    5631
XP_005270546                                                           16    5631
XP_005270543                                                           16    5631
XP_005270542                                                           16    5631
NP_066960                                                              16    5631
NP_001136021                                                           16    5631
NP_001138947                                                           16    5631
NP_077726                                                              16    5631
NP_690850                                                              16    5631
NP_660187                                                              16    7355
NP_149163                                                              16    7355
NP_115972                                                              16    7355
NP_006304                                                              16    7355
NP_001239007                                                           16    7355
NP_114159                                                              16    7355
XP_005269318                                                           16    7355
XP_005269316                                                           16    7355
XP_006714396                                                           16    7355
XP_006714395                                                           16    7355
XP_006714394                                                           16    7355
XP_005263325                                                           16    7355
XP_005263324                                                           16    7355
NP_001273433                                                           15    9605
NP_001273432                                                           15    9605
NP_006635                                                              15    9605
NP_001273434                                                           15    9605
NP_002145                                                              15    9605
NP_055524                                                              15    9605
NP_060493                                                              15    9605
NP_000333                                                              15    9605
NP_009184                                                              15    9605
XP_005257650                                                           15    9605
XP_005257649                                                           15    9605
XP_006719820                                                           15    9605
XP_005266293                                                           15    9605
XP_006713751                                                           15    9605
XP_005247655                                                           15    9605
XP_005247654                                                           15    9605
NP_060749                                                              15    9605
>NP_001186551
          Length = 219

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  KPFVKILT 8
          +PFVKI+T
Sbjct: 21 EPFVKIIT 28
>NP_001243070
          Length = 299

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KPFVKIL 7
          KP+VKIL
Sbjct: 23 KPYVKIL 29
>NP_003045
          Length = 514

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PFVKILTN 9
           PF+ +LTN
Sbjct: 147 PFIGLLTN 154
>NP_065734
          Length = 347

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KPF ++LT
Sbjct: 330 KPFSRVLT 337
>NP_001075445
          Length = 266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KPF ++LT
Sbjct: 249 KPFSRVLT 256
>NP_849194
          Length = 329

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP VK+L N
Sbjct: 168 KPVVKLLHN 176
>NP_056211
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 415 KPLMKVLQN 423
>NP_001269271
          Length = 600

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 356 KPLMKVLQN 364
>NP_001160006
          Length = 575

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           +P VK+LT+
Sbjct: 505 QPLVKVLTD 513
>NP_001160005
          Length = 704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           +P VK+LT+
Sbjct: 634 QPLVKVLTD 642
>NP_001253970
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 398 KPLMKVLQN 406
>NP_006707
          Length = 674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 217 KPFVKV 222
>NP_001253971
          Length = 606

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 362 KPLMKVLQN 370
>XP_006719294
          Length = 2348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KPFVKIL 7
            KPF+K+L
Sbjct: 2263 KPFLKLL 2269
>XP_005250179
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 217 KPFVKV 222
>XP_005250177
          Length = 673

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 216 KPFVKV 221
>XP_005248604
          Length = 666

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           +P VK+LT+
Sbjct: 596 QPLVKVLTD 604
>XP_005248602
          Length = 700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           +P VK+LT+
Sbjct: 630 QPLVKVLTD 638
>XP_006713630
          Length = 620

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 429 KPLMKVLQN 437
>XP_006713629
          Length = 631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 387 KPLMKVLQN 395
>XP_006713628
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 415 KPLMKVLQN 423
>XP_006713627
          Length = 673

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP +K+L N
Sbjct: 429 KPLMKVLQN 437
>XP_005270547
          Length = 178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KPF ++LT
Sbjct: 161 KPFSRVLT 168
>XP_005270546
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KPF ++LT
Sbjct: 176 KPFSRVLT 183
>XP_005270543
          Length = 215

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KPF ++LT
Sbjct: 198 KPFSRVLT 205
>XP_005270542
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KPF ++LT
Sbjct: 329 KPFSRVLT 336
>NP_066960
          Length = 316

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPFVKILTN 9
           KP VK+L N
Sbjct: 155 KPVVKLLYN 163
>NP_001136021
          Length = 690

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           +P VK+LT+
Sbjct: 620 QPLVKVLTD 628
>NP_001138947
          Length = 2351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KPFVKIL 7
            KPF+K+L
Sbjct: 2263 KPFLKLL 2269
>NP_077726
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           +P VK+LT+
Sbjct: 654 QPLVKVLTD 662
>NP_690850
          Length = 1714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PFVKIL 7
          PFVKIL
Sbjct: 93 PFVKIL 98
>NP_660187
          Length = 1344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KPFVKIL 7
           KPF KI+
Sbjct: 359 KPFAKII 365
>NP_149163
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KPFVKIL 7
           KPF KI+
Sbjct: 359 KPFAKII 365
>NP_115972
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KPFVKIL 7
           KPF KI+
Sbjct: 359 KPFAKII 365
>NP_006304
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 754 KPFVKL 759
>NP_001239007
          Length = 981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 783 KPFVKL 788
>NP_114159
          Length = 840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           KP V++L+N
Sbjct: 140 KPVVELLSN 148
>XP_005269318
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 450 KPFVKL 455
>XP_005269316
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPFVKI 6
           KPFVK+
Sbjct: 662 KPFVKL 667
>XP_006714396
          Length = 840

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           KP V++L+N
Sbjct: 140 KPVVELLSN 148
>XP_006714395
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           KP V++L+N
Sbjct: 203 KPVVELLSN 211
>XP_006714394
          Length = 960

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           KP V++L+N
Sbjct: 304 KPVVELLSN 312
>XP_005263325
          Length = 970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           KP V++L+N
Sbjct: 304 KPVVELLSN 312
>XP_005263324
          Length = 1004

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPFVKILTN 9
           KP V++L+N
Sbjct: 304 KPVVELLSN 312
>NP_001273433
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 429 PFSKVLT 435
>NP_001273432
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 427 PFSKVLT 433
>NP_006635
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 427 PFSKVLT 433
>NP_001273434
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 351 PFSKVLT 357
>NP_002145
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 427 PFSKVLT 433
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    PFVKILT 8
            PF K+LT
Sbjct: 2602 PFFKLLT 2608
>NP_060493
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PFVKILTN 9
            PF+  LTN
Sbjct: 1405 PFLDFLTN 1412
>NP_000333
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PFV ILT
Sbjct: 860 PFVLILT 866
>NP_009184
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KPFVKILT 8
           KP++KI +
Sbjct: 161 KPYIKIFS 168
>XP_005257650
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PFV ILT
Sbjct: 795 PFVLILT 801
>XP_005257649
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PFV ILT
Sbjct: 860 PFVLILT 866
>XP_006719820
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 482 PFSKVLT 488
>XP_005266293
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PFVKILT 8
           PF K+LT
Sbjct: 429 PFSKVLT 435
>XP_006713751
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PFVKILTN 9
            PF+  LTN
Sbjct: 1406 PFLDFLTN 1413
>XP_005247655
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PFVKILTN 9
            PF+  LTN
Sbjct: 1406 PFLDFLTN 1413
>XP_005247654
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    PFVKILTN 9
            PF+  LTN
Sbjct: 1406 PFLDFLTN 1413
>NP_060749
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KPFVKILTN 9
          K ++K++TN
Sbjct: 10 KRYIKMITN 18
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.144    0.416 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 505,793
Number of extensions: 731
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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