Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     869
NP_671714                                                              19     869
XP_006715890                                                           19     869
XP_005250160                                                           19     869
XP_005250159                                                           19     869
NP_002476                                                              16    7355
NP_001008225                                                           16    7355
NP_060473                                                              16    7355
NP_840060                                                              16    7355
NP_001167543                                                           16    7355
NP_775898                                                              16    7355
NP_001167542                                                           16    7355
NP_057279                                                              16    7355
NP_001271188                                                           16    7355
XP_006721905                                                           16    7355
XP_006721904                                                           16    7355
XP_006721903                                                           16    7355
XP_006721902                                                           16    7355
XP_006721901                                                           16    7355
XP_005257301                                                           16    7355
XP_006721900                                                           16    7355
XP_005254586                                                           16    7355
XP_005254585                                                           16    7355
XP_005254584                                                           16    7355
XP_005250980                                                           16    7355
XP_005248535                                                           16    7355
NP_003631                                                              15    9605
NP_000123                                                              15    9605
NP_115642                                                              15    9605
NP_071331                                                              15    9605
NP_004178                                                              15    9605
NP_003179                                                              15    9605
NP_001269551                                                           15    9605
NP_663304                                                              15    9605
NP_055591                                                              15    9605
NP_476511                                                              15    9605
NP_001128686                                                           15    9605
NP_001128685                                                           15    9605
NP_476510                                                              15    9605
NP_001254542                                                           15    9605
NP_002263                                                              15    9605
XP_005262092                                                           15    9605
XP_006719775                                                           15    9605
XP_006719774                                                           15    9605
XP_005254057                                                           15    9605
XP_006719772                                                           15    9605
XP_006719771                                                           15    9605
XP_006719770                                                           15    9605
XP_005254054                                                           15    9605
XP_005252342                                                           15    9605
XP_006715616                                                           15    9605
NP_443073                                                              15    9605
>NP_005742
          Length = 3907

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPELEVVRT 9
            KPELEVV T
Sbjct: 2462 KPELEVVLT 2470
>NP_671714
          Length = 3899

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPELEVVRT 9
            KPELEVV T
Sbjct: 2454 KPELEVVLT 2462
>XP_006715890
          Length = 3860

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPELEVVRT 9
            KPELEVV T
Sbjct: 2415 KPELEVVLT 2423
>XP_005250160
          Length = 3939

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPELEVVRT 9
            KPELEVV T
Sbjct: 2494 KPELEVVLT 2502
>XP_005250159
          Length = 3952

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KPELEVVRT 9
            KPELEVV T
Sbjct: 2507 KPELEVVLT 2515
>NP_002476
          Length = 754

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPELEV 6
           KPELE+
Sbjct: 571 KPELEI 576
>NP_001008225
          Length = 1403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPELEVVRT 9
           K ELE +RT
Sbjct: 430 KKELEAMRT 438
>NP_060473
          Length = 1416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPELEVVRT 9
           K ELE +RT
Sbjct: 443 KKELEAMRT 451
>NP_840060
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PELEVVR 8
           PELE+ R
Sbjct: 348 PELEIAR 354
>NP_001167543
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PELEVVR 8
           PELE+ R
Sbjct: 348 PELEIAR 354
>NP_775898
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>NP_001167542
          Length = 420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PELEVVR 8
           PELE+ R
Sbjct: 348 PELEIAR 354
>NP_057279
          Length = 1780

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    KPELEV 6
            KPELE+
Sbjct: 1580 KPELEI 1585
>NP_001271188
          Length = 1820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    KPELEV 6
            KPELE+
Sbjct: 1620 KPELEI 1625
>XP_006721905
          Length = 242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_006721904
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_006721903
          Length = 269

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_006721902
          Length = 282

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_006721901
          Length = 293

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_005257301
          Length = 308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_006721900
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  PELEVV 7
          PELEVV
Sbjct: 73 PELEVV 78
>XP_005254586
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPELEVVRT 9
           K ELE +RT
Sbjct: 419 KKELEAMRT 427
>XP_005254585
          Length = 1405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPELEVVRT 9
           K ELE +RT
Sbjct: 432 KKELEAMRT 440
>XP_005254584
          Length = 1411

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KPELEVVRT 9
           K ELE +RT
Sbjct: 438 KKELEAMRT 446
>XP_005250980
          Length = 672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KPELEV 6
           KPELE+
Sbjct: 489 KPELEI 494
>XP_005248535
          Length = 390

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   PELEVVR 8
           PELE+ R
Sbjct: 277 PELEIAR 283
>NP_003631
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PELEVV 7
           PELE+V
Sbjct: 849 PELEIV 854
>NP_000123
          Length = 2351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    KPELEV 6
            KPE+EV
Sbjct: 1638 KPEIEV 1643
>NP_115642
          Length = 1984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PELEVVRT 9
            P+L +VRT
Sbjct: 1148 PQLHLVRT 1155
>NP_071331
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KPELEVVRT 9
           KP+ E +RT
Sbjct: 301 KPDYEYLRT 309
>NP_004178
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PELEVVRT 9
            P+LE +RT
Sbjct: 1429 PDLERIRT 1436
>NP_003179
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           K +LEV+R+
Sbjct: 562 KKQLEVIRS 570
>NP_001269551
          Length = 1559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PELEVVRT 9
            P+LE +RT
Sbjct: 1428 PDLERIRT 1435
>NP_663304
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           K +LEV+R+
Sbjct: 589 KKQLEVIRS 597
>NP_055591
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 610 KPKSDMVRT 618
>NP_476511
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 562 KPKSDMVRT 570
>NP_001128686
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 660 KPKSDMVRT 668
>NP_001128685
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 612 KPKSDMVRT 620
>NP_476510
          Length = 759

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 690 KPKSDMVRT 698
>NP_001254542
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  PELEVVRT 9
          P LE VRT
Sbjct: 39 PRLESVRT 46
>NP_002263
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   PELEVVRT 9
           PE++ VRT
Sbjct: 128 PEIQKVRT 135
>XP_005262092
          Length = 1557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    PELEVVRT 9
            P+LE +RT
Sbjct: 1426 PDLERIRT 1433
>XP_006719775
          Length = 596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 527 KPKSDMVRT 535
>XP_006719774
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 557 KPKSDMVRT 565
>XP_005254057
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 639 KPKSDMVRT 647
>XP_006719772
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 640 KPKSDMVRT 648
>XP_006719771
          Length = 714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 645 KPKSDMVRT 653
>XP_006719770
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 675 KPKSDMVRT 683
>XP_005254054
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           KP+ ++VRT
Sbjct: 689 KPKSDMVRT 697
>XP_005252342
          Length = 1218

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   PELEVV 7
           PELE+V
Sbjct: 735 PELEIV 740
>XP_006715616
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KPELEVVRT 9
           K +LEV+R+
Sbjct: 459 KKQLEVIRS 467
>NP_443073
          Length = 268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  ELEVVRT 9
          EL++VRT
Sbjct: 58 ELQIVRT 64
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.131    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 718,465
Number of extensions: 1008
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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