Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              20     299
NP_055985                                                              18    1935
NP_001121678                                                           18    1935
NP_001121676                                                           18    1935
NP_001121677                                                           18    1935
NP_061325                                                              18    1935
NP_940998                                                              18    1935
NP_001155313                                                           18    1935
XP_006723893                                                           18    1935
XP_005260515                                                           18    1935
XP_006723892                                                           18    1935
XP_006723891                                                           18    1935
XP_006723890                                                           18    1935
XP_006716505                                                           18    1935
XP_006716504                                                           18    1935
XP_006716503                                                           18    1935
XP_006716502                                                           18    1935
XP_006716501                                                           18    1935
NP_060310                                                              17    4312
XP_006718462                                                           17    4312
NP_689629                                                              16    5631
NP_001138938                                                           16    5631
NP_667341                                                              16    5631
NP_001138939                                                           16    5631
XP_006726144                                                           16    5631
XP_006726052                                                           16    5631
XP_006725966                                                           16    5631
XP_006725965                                                           16    5631
XP_006725871                                                           16    5631
XP_006725755                                                           16    5631
XP_006725541                                                           16    5631
XP_006725094                                                           16    5631
XP_005250850                                                           16    5631
XP_005250849                                                           16    5631
XP_005250848                                                           16    5631
XP_005250847                                                           16    5631
XP_005250846                                                           16    5631
XP_006715112                                                           16    5631
NP_057460                                                              16    7355
NP_001244928                                                           16    7355
NP_775827                                                              16    7355
NP_055901                                                              16    7355
XP_006721607                                                           16    7355
XP_005256736                                                           16    7355
XP_006718532                                                           16    7355
XP_006718531                                                           16    7355
NP_001137447                                                           16    7355
NP_055839                                                              16    7355
NP_001273088                                                           16    7355
NP_001012331                                                           15    9605
NP_002520                                                              15    9605
NP_006010                                                              15    9605
NP_004466                                                              15    9605
NP_001275517                                                           15    9605
NP_001002843                                                           15    9605
NP_001007793                                                           15    9605
NP_060131                                                              15    9605
NP_002334                                                              15    9605
NP_065834                                                              15    9605
NP_072091                                                              15    9605
XP_005258010                                                           15    9605
XP_005258009                                                           15    9605
XP_005258007                                                           15    9605
XP_005273767                                                           15    9605
XP_006718480                                                           15    9605
XP_005273766                                                           15    9605
XP_006710454                                                           15    9605
XP_006710453                                                           15    9605
XP_005270593                                                           15    9605
NP_001896                                                              15    9605
>NP_055365
          Length = 1032

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KNVRDVRGL 9
           KNVR+VRGL
Sbjct: 949 KNVREVRGL 957
>NP_055985
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>NP_001121678
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>NP_001121676
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>NP_001121677
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>NP_061325
          Length = 870

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 643 KNLREVRG 650
>NP_940998
          Length = 867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 643 KNLREVRG 650
>NP_001155313
          Length = 870

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 643 KNLREVRG 650
>XP_006723893
          Length = 870

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 643 KNLREVRG 650
>XP_005260515
          Length = 870

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 643 KNLREVRG 650
>XP_006723892
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 644 KNLREVRG 651
>XP_006723891
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 644 KNLREVRG 651
>XP_006723890
          Length = 871

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 644 KNLREVRG 651
>XP_006716505
          Length = 630

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 417 KNLREVRG 424
>XP_006716504
          Length = 881

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 417 KNLREVRG 424
>XP_006716503
          Length = 1122

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>XP_006716502
          Length = 1122

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>XP_006716501
          Length = 1122

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KNVRDVRG 8
           KN+R+VRG
Sbjct: 658 KNLREVRG 665
>NP_060310
          Length = 251

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KNVRDVRG 8
          KN+ D+RG
Sbjct: 67 KNLSDIRG 74
>XP_006718462
          Length = 4966

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    VRDVRGL 9
            +RDVRGL
Sbjct: 1197 LRDVRGL 1203
>NP_689629
          Length = 333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KNVRDV 6
           KNVRDV
Sbjct: 253 KNVRDV 258
>NP_001138938
          Length = 177

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>NP_667341
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>NP_001138939
          Length = 190

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006726144
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006726052
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006725966
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006725965
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006725871
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006725755
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006725541
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_006725094
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>XP_005250850
          Length = 181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KNVRDV 6
           KNVRDV
Sbjct: 101 KNVRDV 106
>XP_005250849
          Length = 181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KNVRDV 6
           KNVRDV
Sbjct: 101 KNVRDV 106
>XP_005250848
          Length = 181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KNVRDV 6
           KNVRDV
Sbjct: 101 KNVRDV 106
>XP_005250847
          Length = 222

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KNVRDV 6
           KNVRDV
Sbjct: 142 KNVRDV 147
>XP_005250846
          Length = 241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KNVRDV 6
           KNVRDV
Sbjct: 161 KNVRDV 166
>XP_006715112
          Length = 201

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   NVRDVRG 8
           ++RDVRG
Sbjct: 94  HIRDVRG 100
>NP_057460
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVRDVRGL 9
           NVRD +GL
Sbjct: 832 NVRDRQGL 839
>NP_001244928
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVRDVRGL 9
           NVRD +GL
Sbjct: 873 NVRDRQGL 880
>NP_775827
          Length = 444

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN+RD+R
Sbjct: 111 KNLRDMR 117
>NP_055901
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VRDVRG 8
           VRD+RG
Sbjct: 697 VRDIRG 702
>XP_006721607
          Length = 1130

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVRDVRGL 9
           NVRD +GL
Sbjct: 832 NVRDRQGL 839
>XP_005256736
          Length = 1169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   NVRDVRGL 9
           NVRD +GL
Sbjct: 831 NVRDRQGL 838
>XP_006718532
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN+RD+R
Sbjct: 111 KNLRDMR 117
>XP_006718531
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN+RD+R
Sbjct: 111 KNLRDMR 117
>NP_001137447
          Length = 393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KNVRDVRGL 9
           KN+ +VR L
Sbjct: 197 KNIEEVRSL 205
>NP_055839
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRDVRGL 9
           VRD+RG+
Sbjct: 723 VRDLRGI 729
>NP_001273088
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN+RD+R
Sbjct: 111 KNLRDMR 117
>NP_001012331
          Length = 790

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VRDVRGL 9
          +RD+RGL
Sbjct: 84 LRDLRGL 90
>NP_002520
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VRDVRGL 9
          +RD+RGL
Sbjct: 84 LRDLRGL 90
>NP_006010
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KNVRDVRG 8
           + +RDVRG
Sbjct: 106 QELRDVRG 113
>NP_004466
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KNVRDVRGL 9
           KNV+D++ +
Sbjct: 94  KNVQDIKNV 102
>NP_001275517
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN++D+R
Sbjct: 879 KNIKDLR 885
>NP_001002843
          Length = 966

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN++D+R
Sbjct: 866 KNIKDLR 872
>NP_001007793
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VRDVRGL 9
          +RD+RGL
Sbjct: 54 LRDLRGL 60
>NP_060131
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   KNVRDVR 7
           KN++D+R
Sbjct: 879 KNIKDLR 885
>NP_002334
          Length = 710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KNVRDVRG 8
          +N+R VRG
Sbjct: 43 RNMRKVRG 50
>NP_065834
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   NVRDVRGL 9
           N+++ RGL
Sbjct: 173 NIKEARGL 180
>NP_072091
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   NVRDVRGL 9
           NV+DV+ L
Sbjct: 321 NVKDVKAL 328
>XP_005258010
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KNVRDVRGL 9
          KNV+D++ +
Sbjct: 17 KNVQDIKNV 25
>XP_005258009
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  KNVRDVRGL 9
          KNV+D++ +
Sbjct: 45 KNVQDIKNV 53
>XP_005258007
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KNVRDVRGL 9
           KNV+D++ +
Sbjct: 94  KNVQDIKNV 102
>XP_005273767
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KNVRDVRG 8
           + +RDVRG
Sbjct: 106 QELRDVRG 113
>XP_006718480
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KNVRDVRG 8
           + +RDVRG
Sbjct: 106 QELRDVRG 113
>XP_005273766
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KNVRDVRG 8
           + +RDVRG
Sbjct: 106 QELRDVRG 113
>XP_006710454
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NVRDVRGL 9
           +VR++RGL
Sbjct: 200 SVRELRGL 207
>XP_006710453
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NVRDVRGL 9
           +VR++RGL
Sbjct: 200 SVRELRGL 207
>XP_005270593
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NVRDVRGL 9
           +VR++RGL
Sbjct: 200 SVRELRGL 207
>NP_001896
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   NVRDVRGL 9
           +VR++RGL
Sbjct: 200 SVRELRGL 207
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.146    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 470,604
Number of extensions: 704
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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