Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000312                                                              21     229
NP_116200                                                              17    4312
NP_036203                                                              17    4312
XP_005271768                                                           17    4312
XP_005271766                                                           17    4312
NP_477352                                                              16    5631
NP_000057                                                              16    5631
NP_001265472                                                           16    5631
NP_078800                                                              16    5631
XP_005261692                                                           16    5631
XP_005261691                                                           16    5631
XP_005259175                                                           16    5631
XP_005259174                                                           16    5631
XP_006723374                                                           16    5631
XP_005259173                                                           16    5631
XP_006723373                                                           16    5631
XP_006723372                                                           16    5631
XP_005259172                                                           16    5631
XP_005259171                                                           16    5631
XP_006723371                                                           16    5631
XP_006713805                                                           16    5631
XP_005269417                                                           16    5631
XP_005269415                                                           16    5631
XP_005269414                                                           16    5631
XP_005271223                                                           16    5631
XP_006710936                                                           16    5631
NP_067008                                                              16    5631
NP_000431                                                              16    7355
NP_000274                                                              16    7355
NP_001138763                                                           16    7355
NP_003861                                                              16    7355
NP_116188                                                              16    7355
NP_001188358                                                           16    7355
NP_036427                                                              16    7355
NP_036298                                                              16    7355
NP_001186210                                                           16    7355
XP_006724957                                                           16    7355
XP_006724246                                                           16    7355
XP_006724245                                                           16    7355
XP_006724244                                                           16    7355
XP_006724243                                                           16    7355
XP_005261477                                                           16    7355
XP_005261476                                                           16    7355
XP_005261474                                                           16    7355
XP_006724242                                                           16    7355
XP_005261473                                                           16    7355
XP_005261472                                                           16    7355
XP_005255041                                                           16    7355
XP_005251496                                                           16    7355
NP_849193                                                              15    9605
XP_006713080                                                           15    9605
>NP_000312
          Length = 928

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KMYRLAYLR 9
           K+YRLAYLR
Sbjct: 653 KVYRLAYLR 661
>NP_116200
          Length = 411

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  YRLAYLR 9
          YRL YLR
Sbjct: 34 YRLKYLR 40
>NP_036203
          Length = 195

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           +MYR AYL
Sbjct: 143 RMYRPAYL 150
>XP_005271768
          Length = 211

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  YRLAYLR 9
          YRL YLR
Sbjct: 34 YRLKYLR 40
>XP_005271766
          Length = 264

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  YRLAYLR 9
          YRL YLR
Sbjct: 34 YRLKYLR 40
>NP_477352
          Length = 2102

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MYRLAYLR 9
           +YRL Y+R
Sbjct: 896 VYRLEYMR 903
>NP_000057
          Length = 591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  KMYRLAYL 8
          K YR AYL
Sbjct: 82 KRYRYAYL 89
>NP_001265472
          Length = 539

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  KMYRLAYL 8
          K YR AYL
Sbjct: 30 KRYRYAYL 37
>NP_078800
          Length = 1226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+YR AYL
Sbjct: 405 KLYRDAYL 412
>XP_005261692
          Length = 1854

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MYRLAYLR 9
           +YRL Y+R
Sbjct: 924 VYRLEYMR 931
>XP_005261691
          Length = 2099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MYRLAYLR 9
           +YRL Y+R
Sbjct: 924 VYRLEYMR 931
>XP_005259175
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KMYRLAYL 8
          K+Y+L YL
Sbjct: 22 KLYQLVYL 29
>XP_005259174
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 226 KLYQLVYL 233
>XP_006723374
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005259173
          Length = 1099

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 526 KLYQLVYL 533
>XP_006723373
          Length = 1120

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 547 KLYQLVYL 554
>XP_006723372
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005259172
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_005259171
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_006723371
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>XP_006713805
          Length = 1074

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+YR AYL
Sbjct: 223 KLYRDAYL 230
>XP_005269417
          Length = 1104

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+YR AYL
Sbjct: 405 KLYRDAYL 412
>XP_005269415
          Length = 1229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+YR AYL
Sbjct: 378 KLYRDAYL 385
>XP_005269414
          Length = 1256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+YR AYL
Sbjct: 405 KLYRDAYL 412
>XP_005271223
          Length = 628

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMYRLAYL 8
           K YR AYL
Sbjct: 119 KRYRYAYL 126
>XP_006710936
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMYRLAYL 8
           K YR AYL
Sbjct: 121 KRYRYAYL 128
>NP_067008
          Length = 1159

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y+L YL
Sbjct: 586 KLYQLVYL 593
>NP_000431
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y L+YL
Sbjct: 223 KVYHLSYL 230
>NP_000274
          Length = 854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y L+YL
Sbjct: 221 KIYHLSYL 228
>NP_001138763
          Length = 853

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMYRLAYL 8
           K+Y L+YL
Sbjct: 221 KIYHLSYL 228
>NP_003861
          Length = 1657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RLAYLR 9
           RLAYLR
Sbjct: 798 RLAYLR 803
>NP_116188
          Length = 267

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YRLAYLR 9
           +R+AYLR
Sbjct: 218 HRIAYLR 224
>NP_001188358
          Length = 2170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1480 LYRLAFL 1486
>NP_036427
          Length = 2220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>NP_036298
          Length = 956

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MYRLAY 7
           MYRL+Y
Sbjct: 371 MYRLSY 376
>NP_001186210
          Length = 2220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>XP_006724957
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KMYRLAYLR 9
          KM++L +LR
Sbjct: 39 KMFKLRWLR 47
>XP_006724246
          Length = 2103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_006724245
          Length = 2191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1501 LYRLAFL 1507
>XP_006724244
          Length = 2191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>XP_006724243
          Length = 2196

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1501 LYRLAFL 1507
>XP_005261477
          Length = 2200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005261476
          Length = 2210

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1515 LYRLAFL 1521
>XP_005261474
          Length = 2225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1530 LYRLAFL 1536
>XP_006724242
          Length = 2226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005261473
          Length = 2250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005261472
          Length = 2255

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    MYRLAYL 8
            +YRLA+L
Sbjct: 1560 LYRLAFL 1566
>XP_005255041
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RLAYLR 9
           RLAYLR
Sbjct: 798 RLAYLR 803
>XP_005251496
          Length = 653

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   MYRLAY 7
           MYRL+Y
Sbjct: 371 MYRLSY 376
>NP_849193
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MYRLAYLR 9
           MY+++Y R
Sbjct: 717 MYKMSYYR 724
>XP_006713080
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   MYRLAYLR 9
           MY+++Y R
Sbjct: 717 MYKMSYYR 724
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.149    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 458,475
Number of extensions: 794
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package