Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              22     134
NP_001075109                                                           22     134
NP_942133                                                              17    3301
NP_942131                                                              17    3301
NP_942134                                                              17    3301
NP_942135                                                              17    3301
NP_942136                                                              17    3301
NP_148983                                                              17    3301
NP_002598                                                              17    3301
XP_006725385                                                           17    3301
XP_006725384                                                           17    3301
XP_006725383                                                           17    3301
XP_005257325                                                           17    3301
XP_005257324                                                           17    3301
XP_005257323                                                           17    3301
XP_006721916                                                           17    3301
XP_006715796                                                           17    3301
XP_005249827                                                           17    3301
NP_006292                                                              17    4312
NP_001180440                                                           17    4312
NP_060631                                                              17    4312
XP_006719652                                                           17    4312
XP_006719651                                                           17    4312
XP_005269195                                                           17    4312
NP_079321                                                              16    5631
NP_597721                                                              16    5631
NP_001007170                                                           16    5631
NP_001129523                                                           16    5631
NP_700356                                                              16    5631
NP_005099                                                              16    5631
NP_002421                                                              16    5631
XP_005261808                                                           16    5631
XP_005249535                                                           16    5631
XP_006713512                                                           16    5631
XP_006713511                                                           16    5631
NP_001036236                                                           16    7355
NP_005347                                                              16    7355
NP_001161842                                                           16    7355
NP_055595                                                              16    7355
NP_002344                                                              16    7355
XP_006723625                                                           16    7355
XP_006715348                                                           16    7355
XP_005249560                                                           16    7355
XP_006711137                                                           16    7355
XP_005270921                                                           16    7355
XP_005270920                                                           16    7355
XP_005270919                                                           16    7355
XP_006710137                                                           16    7355
NP_710141                                                              16    7355
NP_068556                                                              16    7355
NP_004658                                                              15    9605
NP_002829                                                              15    9605
NP_036271                                                              15    9605
NP_997304                                                              15    9605
XP_006720790                                                           15    9605
XP_005268334                                                           15    9605
XP_005268333                                                           15    9605
XP_006720789                                                           15    9605
XP_006712334                                                           15    9605
XP_006712333                                                           15    9605
XP_006712332                                                           15    9605
XP_005246357                                                           15    9605
XP_006712331                                                           15    9605
XP_005246356                                                           15    9605
XP_006711535                                                           15    9605
NP_742067                                                              15    9605
>NP_008835
          Length = 4128

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KMTSMSPDY 9
            +MTSMSPDY
Sbjct: 2564 EMTSMSPDY 2572
>NP_001075109
          Length = 4097

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    KMTSMSPDY 9
            +MTSMSPDY
Sbjct: 2564 EMTSMSPDY 2572
>NP_942133
          Length = 2346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1663 KMTFKSPEY 1671
>NP_942131
          Length = 2383

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1700 KMTFKSPEY 1708
>NP_942134
          Length = 2288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1605 KMTFKSPEY 1613
>NP_942135
          Length = 2268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1585 KMTFKSPEY 1593
>NP_942136
          Length = 2346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1663 KMTFKSPEY 1671
>NP_148983
          Length = 196

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TSMSPDY 9
           TS++PDY
Sbjct: 182 TSLNPDY 188
>NP_002598
          Length = 211

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TSMSPDY 9
           TS++PDY
Sbjct: 182 TSLNPDY 188
>XP_006725385
          Length = 2038

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1355 KMTFKSPEY 1363
>XP_006725384
          Length = 2268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1585 KMTFKSPEY 1593
>XP_006725383
          Length = 2338

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1655 KMTFKSPEY 1663
>XP_005257325
          Length = 2038

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1355 KMTFKSPEY 1363
>XP_005257324
          Length = 2268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1585 KMTFKSPEY 1593
>XP_005257323
          Length = 2268

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1585 KMTFKSPEY 1593
>XP_006721916
          Length = 2375

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KMTSMSPDY 9
            KMT  SP+Y
Sbjct: 1692 KMTFKSPEY 1700
>XP_006715796
          Length = 211

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TSMSPDY 9
           TS++PDY
Sbjct: 182 TSLNPDY 188
>XP_005249827
          Length = 234

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TSMSPDY 9
           TS++PDY
Sbjct: 196 TSLNPDY 202
>NP_006292
          Length = 859

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMTSMSPD 8
           KM+S SPD
Sbjct: 605 KMSSSSPD 612
>NP_001180440
          Length = 892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMTSMSPD 8
           KM+S SPD
Sbjct: 638 KMSSSSPD 645
>NP_060631
          Length = 706

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KMTSMSPDY 9
           KMT+++P Y
Sbjct: 649 KMTTLTPAY 657
>XP_006719652
          Length = 759

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMTSMSPD 8
           KM+S SPD
Sbjct: 505 KMSSSSPD 512
>XP_006719651
          Length = 892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMTSMSPD 8
           KM+S SPD
Sbjct: 638 KMSSSSPD 645
>XP_005269195
          Length = 892

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMTSMSPD 8
           KM+S SPD
Sbjct: 638 KMSSSSPD 645
>NP_079321
          Length = 529

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   MTSMSP 7
           MTSMSP
Sbjct: 402 MTSMSP 407
>NP_597721
          Length = 744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KMTSMSPD 8
          KMT++SP+
Sbjct: 9  KMTAISPE 16
>NP_001007170
          Length = 256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  KMTSMSPD 8
          KMT++SP+
Sbjct: 9  KMTAISPE 16
>NP_001129523
          Length = 1059

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMTSMSPDY 9
           ++TSM P Y
Sbjct: 118 RVTSMEPGY 126
>NP_700356
          Length = 1119

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMTSMSPDY 9
           ++TSM P Y
Sbjct: 178 RVTSMEPGY 186
>NP_005099
          Length = 536

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MTSMSPD 8
           +TS+SPD
Sbjct: 112 LTSLSPD 118
>NP_002421
          Length = 1320

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TSMSPDY 9
           TS+SP+Y
Sbjct: 916 TSLSPNY 922
>XP_005261808
          Length = 529

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   MTSMSP 7
           MTSMSP
Sbjct: 402 MTSMSP 407
>XP_005249535
          Length = 932

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KMTSMSPDY 9
          K+TS S DY
Sbjct: 19 KLTSKSNDY 27
>XP_006713512
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   MTSMSPD 8
           +TS+SPD
Sbjct: 112 LTSLSPD 118
>XP_006713511
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  MTSMSPD 8
          +TS+SPD
Sbjct: 85 LTSLSPD 91
>NP_001036236
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMTSMSPD 8
           K  SMSPD
Sbjct: 276 KQGSMSPD 283
>NP_005347
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMTSMSPD 8
           K  SMSPD
Sbjct: 276 KQGSMSPD 283
>NP_001161842
          Length = 1782

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KMTSMSPDY 9
           ++TS+S DY
Sbjct: 818 RLTSVSRDY 826
>NP_055595
          Length = 1698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KMTSMSPDY 9
           ++TS+S DY
Sbjct: 734 RLTSVSRDY 742
>NP_002344
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  KMTSMSPD 8
          KMT  SPD
Sbjct: 40 KMTVCSPD 47
>XP_006723625
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MTSMSPDY 9
           M SMSP Y
Sbjct: 130 MNSMSPMY 137
>XP_006715348
          Length = 1734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KMTSMSPDY 9
           ++TS+S DY
Sbjct: 766 RLTSVSRDY 774
>XP_005249560
          Length = 1750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KMTSMSPDY 9
           ++TS+S DY
Sbjct: 786 RLTSVSRDY 794
>XP_006711137
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 MTSMSPDY 9
         MTS +PD+
Sbjct: 1 MTSWNPDH 8
>XP_005270921
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMTSMSPD 8
           K  SMSPD
Sbjct: 320 KQGSMSPD 327
>XP_005270920
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMTSMSPD 8
           K  SMSPD
Sbjct: 334 KQGSMSPD 341
>XP_005270919
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMTSMSPD 8
           K  SMSPD
Sbjct: 334 KQGSMSPD 341
>XP_006710137
          Length = 413

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 MTSMSPDY 9
         MTS +PD+
Sbjct: 1 MTSWNPDH 8
>NP_710141
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MTSMSPDY 9
           M SMSP Y
Sbjct: 130 MNSMSPMY 137
>NP_068556
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   MTSMSPDY 9
           M SMSP Y
Sbjct: 136 MNSMSPMY 143
>NP_004658
          Length = 4834

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    KMTSMSPD 8
            KM+S  PD
Sbjct: 4450 KMSSFGPD 4457
>NP_002829
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TSMSPD 8
          TS+SPD
Sbjct: 74 TSLSPD 79
>NP_036271
          Length = 458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMTSMSPD 8
           K+T +SPD
Sbjct: 413 KVTYLSPD 420
>NP_997304
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  KMTSMSP 7
          KMTS SP
Sbjct: 86 KMTSPSP 92
>XP_006720790
          Length = 4748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    KMTSMSPD 8
            KM+S  PD
Sbjct: 4364 KMSSFGPD 4371
>XP_005268334
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    KMTSMSPD 8
            KM+S  PD
Sbjct: 4412 KMSSFGPD 4419
>XP_005268333
          Length = 4796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    KMTSMSPD 8
            KM+S  PD
Sbjct: 4412 KMSSFGPD 4419
>XP_006720789
          Length = 4829

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    KMTSMSPD 8
            KM+S  PD
Sbjct: 4445 KMSSFGPD 4452
>XP_006712334
          Length = 1891

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 904 KRTSLHPSY 912
>XP_006712333
          Length = 1714

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 716 KRTSLHPSY 724
>XP_006712332
          Length = 1892

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 905 KRTSLHPSY 913
>XP_005246357
          Length = 1899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 905 KRTSLHPSY 913
>XP_006712331
          Length = 1902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 904 KRTSLHPSY 912
>XP_005246356
          Length = 1903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 905 KRTSLHPSY 913
>XP_006711535
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  TSMSPD 8
          TS+SPD
Sbjct: 74 TSLSPD 79
>NP_742067
          Length = 1888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMTSMSPDY 9
           K TS+ P Y
Sbjct: 905 KRTSLHPSY 913
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.307    0.115    0.323 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 661,155
Number of extensions: 814
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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