Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001167554                                                           19     665
NP_001167553                                                           19     665
NP_060322                                                              19     665
NP_001167552                                                           19     665
NP_000305                                                              18    1482
XP_006717989                                                           18    1482
NP_000151                                                              18    1935
XP_006722340                                                           18    1935
XP_006722339                                                           18    1935
NP_001171795                                                           17    3301
NP_001171802                                                           17    3301
NP_001171796                                                           17    3301
NP_116127                                                              17    3301
NP_071451                                                              17    3301
XP_006711644                                                           17    3301
XP_006721553                                                           17    4312
XP_006721552                                                           17    4312
XP_006721551                                                           17    4312
XP_006721550                                                           17    4312
XP_005256620                                                           17    4312
NP_001274141                                                           16    5631
NP_003226                                                              16    5631
NP_065867                                                              16    5631
NP_001116291                                                           16    5631
XP_005251100                                                           16    5631
XP_006716686                                                           16    5631
XP_005251099                                                           16    5631
XP_005251097                                                           16    5631
XP_005251095                                                           16    5631
XP_006716685                                                           16    5631
XP_006716433                                                           16    5631
XP_005273633                                                           16    5631
XP_006716432                                                           16    5631
XP_005273632                                                           16    5631
XP_005246008                                                           16    5631
XP_005246007                                                           16    5631
NP_112561                                                              16    5631
NP_055112                                                              16    7355
NP_001167558                                                           16    7355
NP_858045                                                              16    7355
NP_006525                                                              16    7355
NP_001167559                                                           16    7355
XP_005274573                                                           16    7355
NP_001165907                                                           15    9605
NP_002628                                                              15    9605
NP_000283                                                              15    9605
NP_071324                                                              15    9605
NP_001116142                                                           15    9605
NP_006531                                                              15    9605
NP_071761                                                              15    9605
NP_758872                                                              15    9605
NP_060875                                                              15    9605
NP_055670                                                              15    9605
NP_002229                                                              15    9605
XP_006724724                                                           15    9605
XP_006724561                                                           15    9605
XP_005274607                                                           15    9605
XP_005274605                                                           15    9605
XP_006724560                                                           15    9605
XP_006724559                                                           15    9605
XP_005258057                                                           15    9605
XP_005251190                                                           15    9605
XP_005251188                                                           15    9605
XP_005251189                                                           15    9605
XP_005251187                                                           15    9605
XP_005251186                                                           15    9605
XP_005251185                                                           15    9605
>NP_001167554
          Length = 1039

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMMFETIQC 9
           KM+FET+ C
Sbjct: 977 KMLFETLTC 985
>NP_001167553
          Length = 1040

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMMFETIQC 9
           KM+FET+ C
Sbjct: 978 KMLFETLTC 986
>NP_060322
          Length = 1062

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KMMFETIQC 9
            KM+FET+ C
Sbjct: 1000 KMLFETLTC 1008
>NP_001167552
          Length = 1062

 Score = 19.2 bits (38), Expect =   665
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    KMMFETIQC 9
            KM+FET+ C
Sbjct: 1000 KMLFETLTC 1008
>NP_000305
          Length = 403

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KMMFETI 7
           KMMFETI
Sbjct: 197 KMMFETI 203
>XP_006717989
          Length = 388

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 1   KMMFETI 7
           KMMFETI
Sbjct: 182 KMMFETI 188
>NP_000151
          Length = 477

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           K +FE +QC
Sbjct: 286 KCLFENVQC 294
>XP_006722340
          Length = 477

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           K +FE +QC
Sbjct: 286 KCLFENVQC 294
>XP_006722339
          Length = 523

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           K +FE +QC
Sbjct: 316 KCLFENVQC 324
>NP_001171795
          Length = 382

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          FET+QC
Sbjct: 53 FETLQC 58
>NP_001171802
          Length = 192

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          FET+QC
Sbjct: 47 FETLQC 52
>NP_001171796
          Length = 287

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          FET+QC
Sbjct: 47 FETLQC 52
>NP_116127
          Length = 376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          FET+QC
Sbjct: 47 FETLQC 52
>NP_071451
          Length = 1025

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           KMM++ I C
Sbjct: 852 KMMYKAIHC 860
>XP_006711644
          Length = 293

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          FET+QC
Sbjct: 53 FETLQC 58
>XP_006721553
          Length = 2286

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KMMFETIQC 9
            ++ F TIQC
Sbjct: 1235 RIRFSTIQC 1243
>XP_006721552
          Length = 2299

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KMMFETIQC 9
            ++ F TIQC
Sbjct: 1235 RIRFSTIQC 1243
>XP_006721551
          Length = 2301

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KMMFETIQC 9
            ++ F TIQC
Sbjct: 1197 RIRFSTIQC 1205
>XP_006721550
          Length = 2326

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KMMFETIQC 9
            ++ F TIQC
Sbjct: 1235 RIRFSTIQC 1243
>XP_005256620
          Length = 2339

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KMMFETIQC 9
            ++ F TIQC
Sbjct: 1235 RIRFSTIQC 1243
>NP_001274141
          Length = 929

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  MFETIQC 9
          +FE++QC
Sbjct: 21 VFESVQC 27
>NP_003226
          Length = 2768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>NP_065867
          Length = 1029

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MFETIQC 9
           +FE++QC
Sbjct: 121 VFESVQC 127
>NP_001116291
          Length = 1028

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MFETIQC 9
           +FE++QC
Sbjct: 121 VFESVQC 127
>XP_005251100
          Length = 2103

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>XP_006716686
          Length = 2111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>XP_005251099
          Length = 2121

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>XP_005251097
          Length = 2178

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>XP_005251095
          Length = 2704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>XP_006716685
          Length = 2747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  FETIQC 9
          F+T+QC
Sbjct: 58 FQTVQC 63
>XP_006716433
          Length = 3069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KMMFETIQ 8
            +MM ETIQ
Sbjct: 1974 QMMMETIQ 1981
>XP_005273633
          Length = 3069

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KMMFETIQ 8
            +MM ETIQ
Sbjct: 1974 QMMMETIQ 1981
>XP_006716432
          Length = 3172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KMMFETIQ 8
            +MM ETIQ
Sbjct: 2077 QMMMETIQ 2084
>XP_005273632
          Length = 3172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KMMFETIQ 8
            +MM ETIQ
Sbjct: 2077 QMMMETIQ 2084
>XP_005246008
          Length = 984

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MFETIQC 9
           +FE++QC
Sbjct: 121 VFESVQC 127
>XP_005246007
          Length = 985

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   MFETIQC 9
           +FE++QC
Sbjct: 121 VFESVQC 127
>NP_112561
          Length = 2789

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KMMFETIQ 8
            +MM ETIQ
Sbjct: 1694 QMMMETIQ 1701
>NP_055112
          Length = 254

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  KMMFETIQC 9
          + MFE + C
Sbjct: 26 RQMFEPVSC 34
>NP_001167558
          Length = 1423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           +  +ET+QC
Sbjct: 218 RQRYETMQC 226
>NP_858045
          Length = 1424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           +  +ET+QC
Sbjct: 218 RQRYETMQC 226
>NP_006525
          Length = 1420

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           +  +ET+QC
Sbjct: 218 RQRYETMQC 226
>NP_001167559
          Length = 1415

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KMMFETIQC 9
           +  +ET+QC
Sbjct: 218 RQRYETMQC 226
>XP_005274573
          Length = 382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMMFETIQ 8
           K+MF T+Q
Sbjct: 350 KLMFRTMQ 357
>NP_001165907
          Length = 1151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>NP_002628
          Length = 1223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>NP_000283
          Length = 1235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>NP_071324
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3   MFETIQC 9
           +FE+++C
Sbjct: 434 LFESVEC 440
>NP_001116142
          Length = 1210

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>NP_006531
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
>NP_071761
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KMMFETIQ 8
           K +FETI+
Sbjct: 371 KTLFETIE 378
>NP_758872
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   MMFETIQC 9
           M F+T+ C
Sbjct: 595 MEFQTVHC 602
>NP_060875
          Length = 184

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMMFETIQ 8
           KM+FET Q
Sbjct: 171 KMVFETGQ 178
>NP_055670
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   MMFETIQC 9
           ++FE  QC
Sbjct: 677 LLFEVTQC 684
>NP_002229
          Length = 962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2   MMFETIQC 9
           M F+T+ C
Sbjct: 568 MEFQTVHC 575
>XP_006724724
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>XP_006724561
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 138 LFENIEC 144
>XP_005274607
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>XP_005274605
          Length = 1217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>XP_006724560
          Length = 1225

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>XP_006724559
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   MFETIQC 9
           +FE I+C
Sbjct: 320 LFENIEC 326
>XP_005258057
          Length = 172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KMMFETIQ 8
           KM+FET Q
Sbjct: 159 KMVFETGQ 166
>XP_005251190
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
>XP_005251188
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
>XP_005251189
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
>XP_005251187
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
>XP_005251186
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
>XP_005251185
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   FETIQC 9
           +ET+QC
Sbjct: 224 YETMQC 229
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.342    0.136    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 383,229
Number of extensions: 530
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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