Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              19     869
NP_444254                                                              19     869
NP_444253                                                              19     869
NP_444255                                                              19     869
XP_005247551                                                           19     869
XP_005247550                                                           19     869
XP_006713712                                                           19     869
XP_005247549                                                           19     869
NP_001243239                                                           17    2528
NP_055720                                                              17    2528
XP_005246524                                                           17    2528
XP_006712499                                                           17    2528
XP_006712498                                                           17    2528
NP_963844                                                              17    4312
NP_004620                                                              16    5631
NP_004044                                                              16    7355
NP_001161212                                                           16    7355
NP_001164160                                                           16    7355
NP_543151                                                              16    7355
NP_001164157                                                           16    7355
NP_001164158                                                           16    7355
NP_001164159                                                           16    7355
NP_689424                                                              16    7355
NP_057060                                                              16    7355
XP_005273285                                                           16    7355
XP_006710741                                                           16    7355
XP_006710740                                                           16    7355
XP_006710438                                                           16    7355
XP_006710437                                                           16    7355
XP_006710436                                                           16    7355
XP_006710435                                                           16    7355
XP_006710434                                                           16    7355
XP_006710433                                                           16    7355
XP_006710432                                                           16    7355
XP_006710431                                                           16    7355
XP_006710430                                                           16    7355
XP_006710429                                                           16    7355
NP_899234                                                              16    7355
NP_001277238                                                           15    9605
NP_001894                                                              15    9605
NP_001277236                                                           15    9605
XP_005248822                                                           15    9605
XP_006714599                                                           15    9605
NP_078852                                                              15    9605
>NP_444256
          Length = 1794

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1627 KTGNAVRAI 1635
>NP_444254
          Length = 1845

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1678 KTGNAVRAI 1686
>NP_444253
          Length = 1914

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1747 KTGNAVRAI 1755
>NP_444255
          Length = 1863

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1696 KTGNAVRAI 1704
>XP_005247551
          Length = 1855

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1688 KTGNAVRAI 1696
>XP_005247550
          Length = 1856

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1689 KTGNAVRAI 1697
>XP_006713712
          Length = 1923

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1757 KTGNAVRAI 1765
>XP_005247549
          Length = 1924

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KMGNAVRAI 9
            K GNAVRAI
Sbjct: 1757 KTGNAVRAI 1765
>NP_001243239
          Length = 598

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMGNAVRAI 9
           KMGN+V+ I
Sbjct: 507 KMGNSVKGI 515
>NP_055720
          Length = 669

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMGNAVRAI 9
           KMGN+V+ I
Sbjct: 507 KMGNSVKGI 515
>XP_005246524
          Length = 559

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMGNAVRAI 9
           KMGN+V+ I
Sbjct: 507 KMGNSVKGI 515
>XP_006712499
          Length = 604

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMGNAVRAI 9
           KMGN+V+ I
Sbjct: 507 KMGNSVKGI 515
>XP_006712498
          Length = 661

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KMGNAVRAI 9
           KMGN+V+ I
Sbjct: 507 KMGNSVKGI 515
>NP_963844
          Length = 277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 MGNAVRAI 9
         MGN +RA+
Sbjct: 1 MGNTIRAL 8
>NP_004620
          Length = 622

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KMGNAVRAI 9
           KMGN  RA+
Sbjct: 258 KMGNPQRAL 266
>NP_004044
          Length = 437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  GNAVRA 8
          GNAVRA
Sbjct: 26 GNAVRA 31
>NP_001161212
          Length = 428

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KMGNAVRAI 9
          K GN +RA+
Sbjct: 13 KRGNGLRAV 21
>NP_001164160
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 377 LGNAARAL 384
>NP_543151
          Length = 1070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 557 LGNAARAL 564
>NP_001164157
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 553 LGNAARAL 560
>NP_001164158
          Length = 1056

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 543 LGNAARAL 550
>NP_001164159
          Length = 1005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 492 LGNAARAL 499
>NP_689424
          Length = 396

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMGNAVRAI 9
           +MG  VRA+
Sbjct: 173 RMGQTVRAV 181
>NP_057060
          Length = 451

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMGNAVRAI 9
           +MG  VRA+
Sbjct: 228 RMGQTVRAV 236
>XP_005273285
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KMGNAVRAI 9
          K GN +RA+
Sbjct: 13 KRGNGLRAV 21
>XP_006710741
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMGNAVRAI 9
           +MG  VRA+
Sbjct: 164 RMGQTVRAV 172
>XP_006710740
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KMGNAVRAI 9
           +MG  VRA+
Sbjct: 250 RMGQTVRAV 258
>XP_006710438
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 463 LGNAARAL 470
>XP_006710437
          Length = 1009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 463 LGNAARAL 470
>XP_006710436
          Length = 1023

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 477 LGNAARAL 484
>XP_006710435
          Length = 1034

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 521 LGNAARAL 528
>XP_006710434
          Length = 1103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 557 LGNAARAL 564
>XP_006710433
          Length = 1169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 656 LGNAARAL 663
>XP_006710432
          Length = 1202

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 656 LGNAARAL 663
>XP_006710431
          Length = 1205

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 692 LGNAARAL 699
>XP_006710430
          Length = 1226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 713 LGNAARAL 720
>XP_006710429
          Length = 1238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   MGNAVRAI 9
           +GNA RA+
Sbjct: 692 LGNAARAL 699
>NP_899234
          Length = 1134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KMGNAVRAI 9
           K GNAV+ I
Sbjct: 150 KFGNAVQPI 158
>NP_001277238
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  KMGNAVRA 8
          K GN VRA
Sbjct: 17 KRGNMVRA 24
>NP_001894
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMGNAVRA 8
           K GN VRA
Sbjct: 120 KRGNMVRA 127
>NP_001277236
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMGNAVRA 8
           K GN VRA
Sbjct: 120 KRGNMVRA 127
>XP_005248822
          Length = 452

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMGNAVRAI 9
           K GN  RA+
Sbjct: 213 KTGNVARAV 221
>XP_006714599
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KMGNAVRA 8
           K GN VRA
Sbjct: 120 KRGNMVRA 127
>NP_078852
          Length = 451

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KMGNAVRAI 9
           K GN  RA+
Sbjct: 212 KTGNVARAV 220
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.132    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 373,343
Number of extensions: 421
Number of successful extensions: 44
Number of sequences better than 10000.0: 44
Number of HSP's gapped: 44
Number of HSP's successfully gapped: 44
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package