Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     390
NP_001075109                                                           20     390
NP_004787                                                              17    4312
NP_705618                                                              17    4312
NP_004289                                                              17    4312
NP_001265241                                                           17    4312
XP_006720386                                                           17    4312
XP_006720385                                                           17    4312
XP_005268275                                                           17    4312
NP_001164009                                                           16    7355
NP_001131074                                                           16    7355
NP_057039                                                              16    7355
NP_775814                                                              16    7355
XP_005247256                                                           16    7355
XP_006713590                                                           16    7355
XP_006713589                                                           16    7355
XP_005247255                                                           16    7355
XP_005264409                                                           16    7355
XP_005264408                                                           16    7355
NP_001018048                                                           15    9605
NP_004159                                                              15    9605
NP_056001                                                              15    9605
NP_001018047                                                           15    9605
NP_000415                                                              15    9605
NP_150648                                                              15    9605
NP_001032249                                                           15    9605
NP_005547                                                              15    9605
NP_001269657                                                           15    9605
NP_689495                                                              15    9605
NP_004527                                                              15    9605
NP_075043                                                              15    9605
NP_060385                                                              15    9605
NP_004684                                                              15    9605
NP_116176                                                              15    9605
NP_787028                                                              15    9605
NP_001129737                                                           15    9605
NP_036553                                                              15    9605
NP_476429                                                              15    9605
NP_775487                                                              15    9605
XP_006725521                                                           15    9605
XP_006725520                                                           15    9605
XP_006725519                                                           15    9605
XP_006725518                                                           15    9605
XP_006725517                                                           15    9605
XP_006725516                                                           15    9605
XP_005276858                                                           15    9605
XP_005276857                                                           15    9605
XP_006726285                                                           15    9605
XP_006726284                                                           15    9605
XP_006726283                                                           15    9605
XP_006726282                                                           15    9605
XP_006719533                                                           15    9605
XP_006719456                                                           15    9605
XP_005268916                                                           15    9605
XP_006719455                                                           15    9605
XP_005268753                                                           15    9605
XP_005268752                                                           15    9605
XP_006714693                                                           15    9605
XP_005248580                                                           15    9605
XP_006714692                                                           15    9605
XP_006714691                                                           15    9605
XP_006714690                                                           15    9605
XP_006714689                                                           15    9605
XP_005248386                                                           15    9605
XP_005247960                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLYGELALK 9
           K YGELALK
Sbjct: 155 KFYGELALK 163
>NP_001075109
          Length = 4097

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLYGELALK 9
           K YGELALK
Sbjct: 155 KFYGELALK 163
>NP_004787
          Length = 1061

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KLYGELALK 9
          K+YGE+  K
Sbjct: 58 KIYGEVVFK 66
>NP_705618
          Length = 1391

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KLYGELA 7
            KLYGE A
Sbjct: 1187 KLYGEFA 1193
>NP_004289
          Length = 1332

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KLYGELA 7
            KLYGE A
Sbjct: 1128 KLYGEFA 1134
>NP_001265241
          Length = 1327

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    KLYGELA 7
            KLYGE A
Sbjct: 1123 KLYGEFA 1129
>XP_006720386
          Length = 1571

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLYGELALK 9
           K+YGE+  K
Sbjct: 431 KIYGEVVFK 439
>XP_006720385
          Length = 1683

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLYGELALK 9
           K+YGE+  K
Sbjct: 439 KIYGEVVFK 447
>XP_005268275
          Length = 1684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLYGELALK 9
           K+YGE+  K
Sbjct: 443 KIYGEVVFK 451
>NP_001164009
          Length = 539

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYGE+
Sbjct: 262 KLYGEI 267
>NP_001131074
          Length = 274

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KLYGEL 6
          K+YGEL
Sbjct: 85 KIYGEL 90
>NP_057039
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           K+YGEL
Sbjct: 108 KIYGEL 113
>NP_775814
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYGE+
Sbjct: 262 KLYGEI 267
>XP_005247256
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KLYGEL 6
          KLYGE+
Sbjct: 45 KLYGEI 50
>XP_006713590
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYGE+
Sbjct: 262 KLYGEI 267
>XP_006713589
          Length = 778

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYGE+
Sbjct: 262 KLYGEI 267
>XP_005247255
          Length = 795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYGE+
Sbjct: 290 KLYGEI 295
>XP_005264409
          Length = 170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           K+YGEL
Sbjct: 108 KIYGEL 113
>XP_005264408
          Length = 297

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           K+YGEL
Sbjct: 108 KIYGEL 113
>NP_001018048
          Length = 3069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLYGELAL 8
           K+YG+L L
Sbjct: 765 KIYGKLPL 772
>NP_004159
          Length = 664

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYG+L
Sbjct: 541 KLYGDL 546
>NP_056001
          Length = 3095

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLYGELAL 8
           K+YG+L L
Sbjct: 765 KIYGKLPL 772
>NP_001018047
          Length = 3135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLYGELAL 8
           K+YG+L L
Sbjct: 765 KIYGKLPL 772
>NP_000415
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 421 GELALK 426
>NP_150648
          Length = 3174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLYGELAL 8
           K+YG+L L
Sbjct: 765 KIYGKLPL 772
>NP_001032249
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KLYGELA 7
           K YGE+A
Sbjct: 273 KTYGEMA 279
>NP_005547
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 343 GELALK 348
>NP_001269657
          Length = 442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KLYGELA 7
           K YGE+A
Sbjct: 235 KTYGEMA 241
>NP_689495
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KLYGELA 7
           K YGE+A
Sbjct: 273 KTYGEMA 279
>NP_004527
          Length = 1403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>NP_075043
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 531 GELALK 536
>NP_060385
          Length = 579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLYGELA 7
           +LYG+LA
Sbjct: 546 RLYGKLA 552
>NP_004684
          Length = 551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 402 GELALK 407
>NP_116176
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LYGELALK 9
           LYGE+ L+
Sbjct: 125 LYGEIELQ 132
>NP_787028
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 397 GELALK 402
>NP_001129737
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  LYGELAL 8
          L+GE+AL
Sbjct: 6  LFGEMAL 12
>NP_036553
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    GELALK 9
            GELALK
Sbjct: 1872 GELALK 1877
>NP_476429
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGELALK 9
           +GE+ALK
Sbjct: 452 HGEMALK 458
>NP_775487
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 364 GELALK 369
>XP_006725521
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_006725520
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 305 GELALK 310
>XP_006725519
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 429 GELALK 434
>XP_006725518
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 509 GELALK 514
>XP_006725517
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_006725516
          Length = 1352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_005276858
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_005276857
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 305 GELALK 310
>XP_006726285
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 429 GELALK 434
>XP_006726284
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 509 GELALK 514
>XP_006726283
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_006726282
          Length = 1352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_006719533
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLYGELA 7
           +LYG+LA
Sbjct: 489 RLYGKLA 495
>XP_006719456
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGELALK 9
           +GE+ALK
Sbjct: 404 HGEMALK 410
>XP_005268916
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGELALK 9
           +GE+ALK
Sbjct: 430 HGEMALK 436
>XP_006719455
          Length = 616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   YGELALK 9
           +GE+ALK
Sbjct: 440 HGEMALK 446
>XP_005268753
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 135 GELALK 140
>XP_005268752
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 254 GELALK 259
>XP_006714693
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_005248580
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 305 GELALK 310
>XP_006714692
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 429 GELALK 434
>XP_006714691
          Length = 1219

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 509 GELALK 514
>XP_006714690
          Length = 1348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_006714689
          Length = 1352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   GELALK 9
           GELALK
Sbjct: 693 GELALK 698
>XP_005248386
          Length = 668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLYGEL 6
           KLYG+L
Sbjct: 541 KLYGDL 546
>XP_005247960
          Length = 463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   KLYGELA 7
           K YGE+A
Sbjct: 256 KTYGEMA 262
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.143    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 452,437
Number of extensions: 547
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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