Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           20     509
NP_001257437                                                           20     509
NP_006281                                                              20     509
XP_005267176                                                           20     509
NP_001001521                                                           18    1935
NP_006750                                                              18    1935
XP_005264594                                                           18    1935
XP_005264595                                                           18    1935
XP_005251783                                                           17    2528
NP_001155097                                                           17    2528
NP_079498                                                              17    3301
NP_001276049                                                           16    7355
NP_001276048                                                           16    7355
NP_001276050                                                           16    7355
NP_115602                                                              16    7355
NP_005449                                                              16    7355
NP_079265                                                              16    7355
NP_619520                                                              16    7355
NP_055781                                                              16    7355
XP_005252373                                                           16    7355
XP_005251669                                                           16    7355
XP_005251668                                                           16    7355
XP_005251666                                                           16    7355
XP_005251665                                                           16    7355
XP_006713096                                                           16    7355
XP_006713095                                                           16    7355
XP_005246923                                                           16    7355
NP_783297                                                              15    9605
NP_003248                                                              15    9605
NP_689914                                                              15    9605
NP_542415                                                              15    9605
NP_542416                                                              15    9605
NP_542414                                                              15    9605
NP_006255                                                              15    9605
NP_006370                                                              15    9605
XP_006725623                                                           15    9605
XP_006725622                                                           15    9605
XP_006725621                                                           15    9605
XP_006725620                                                           15    9605
XP_006725619                                                           15    9605
XP_006725618                                                           15    9605
XP_006725617                                                           15    9605
XP_006725616                                                           15    9605
XP_005254678                                                           15    9605
XP_006720724                                                           15    9605
XP_005254677                                                           15    9605
XP_005254676                                                           15    9605
XP_005254675                                                           15    9605
XP_006720723                                                           15    9605
XP_005254674                                                           15    9605
XP_005254673                                                           15    9605
XP_005250170                                                           15    9605
XP_005263224                                                           15    9605
>NP_001257436
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KLVVLKTNG 9
          KLV LKTNG
Sbjct: 91 KLVALKTNG 99
>NP_001257437
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KLVVLKTNG 9
          KLV LKTNG
Sbjct: 91 KLVALKTNG 99
>NP_006281
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KLVVLKTNG 9
          KLV LKTNG
Sbjct: 91 KLVALKTNG 99
>XP_005267176
          Length = 790

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  KLVVLKTNG 9
          KLV LKTNG
Sbjct: 91 KLVALKTNG 99
>NP_001001521
          Length = 497

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KLVV+K NG
Sbjct: 96  KLVVVKLNG 104
>NP_006750
          Length = 508

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KLVV+K NG
Sbjct: 107 KLVVVKLNG 115
>XP_005264594
          Length = 497

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KLVV+K NG
Sbjct: 96  KLVVVKLNG 104
>XP_005264595
          Length = 497

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KLVV+K NG
Sbjct: 96  KLVVVKLNG 104
>XP_005251783
          Length = 156

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KLV++K NG
Sbjct: 114 KLVIVKQNG 122
>NP_001155097
          Length = 156

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KLV++K NG
Sbjct: 114 KLVIVKQNG 122
>NP_079498
          Length = 313

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLVVLKTNG 9
           KL+++ TNG
Sbjct: 207 KLILISTNG 215
>NP_001276049
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>NP_001276048
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>NP_001276050
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>NP_115602
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>NP_005449
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLVVLKTN 8
           KL+ L+TN
Sbjct: 743 KLITLRTN 750
>NP_079265
          Length = 922

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVL TNG
Sbjct: 482 VVLNTNG 488
>NP_619520
          Length = 1194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KLVVLKTNG 9
          KLV + TNG
Sbjct: 73 KLVYVHTNG 81
>NP_055781
          Length = 1155

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KLVVLKTNG 9
          KLV + TNG
Sbjct: 34 KLVYVHTNG 42
>XP_005252373
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLVVLKTN 8
           KL+ L+TN
Sbjct: 485 KLITLRTN 492
>XP_005251669
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>XP_005251668
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>XP_005251666
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>XP_005251665
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           K+ VLK NG
Sbjct: 397 KIKVLKKNG 405
>XP_006713096
          Length = 1162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  KLVVLKTNG 9
          KLV + TNG
Sbjct: 41 KLVYVHTNG 49
>XP_006713095
          Length = 1222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVVLKTNG 9
           KLV + TNG
Sbjct: 101 KLVYVHTNG 109
>XP_005246923
          Length = 748

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVL TNG
Sbjct: 308 VVLNTNG 314
>NP_783297
          Length = 1668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 228 VVLKING 234
>NP_003248
          Length = 1748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 228 VVLKING 234
>NP_689914
          Length = 5058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    VVLKTNG 9
            +VLKT+G
Sbjct: 3634 IVLKTSG 3640
>NP_542415
          Length = 2294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VVLKTNG 9
            V+LK NG
Sbjct: 1362 VILKVNG 1368
>NP_542416
          Length = 2490

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VVLKTNG 9
            V+LK NG
Sbjct: 1558 VILKVNG 1564
>NP_542414
          Length = 2485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VVLKTNG 9
            V+LK NG
Sbjct: 1553 VILKVNG 1559
>NP_006255
          Length = 2466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VVLKTNG 9
            V+LK NG
Sbjct: 1534 VILKVNG 1540
>NP_006370
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLVVLKTN 8
           K+VVL TN
Sbjct: 458 KVVVLPTN 465
>XP_006725623
          Length = 1766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 226 VVLKING 232
>XP_006725622
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 232 VVLKING 238
>XP_006725621
          Length = 1735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_006725620
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_006725619
          Length = 1768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 228 VVLKING 234
>XP_006725618
          Length = 1772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 232 VVLKING 238
>XP_006725617
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_006725616
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_005254678
          Length = 1766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 226 VVLKING 232
>XP_006720724
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 232 VVLKING 238
>XP_005254677
          Length = 1735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_005254676
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_005254675
          Length = 1768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 228 VVLKING 234
>XP_006720723
          Length = 1772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 232 VVLKING 238
>XP_005254674
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_005254673
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   VVLKTNG 9
           VVLK NG
Sbjct: 295 VVLKING 301
>XP_005250170
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLVVLKTN 8
           K+VVL TN
Sbjct: 400 KVVVLPTN 407
>XP_005263224
          Length = 2491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    VVLKTNG 9
            V+LK NG
Sbjct: 1559 VILKVNG 1565
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.314    0.137    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 445,427
Number of extensions: 840
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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