Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006197                                                              18    1135
XP_006714104                                                           18    1135
XP_005265800                                                           18    1135
XP_006714103                                                           18    1135
XP_006714102                                                           18    1135
NP_004357                                                              17    4312
NP_001164560                                                           17    4312
NP_001164559                                                           17    4312
NP_001164558                                                           17    4312
NP_005968                                                              17    4312
NP_036430                                                              17    4312
NP_898865                                                              17    4312
NP_898864                                                              17    4312
XP_005266543                                                           17    4312
XP_005266542                                                           17    4312
XP_006713552                                                           17    4312
XP_006713551                                                           17    4312
NP_001155971                                                           17    4312
NP_001180442                                                           16    5631
NP_001180443                                                           16    5631
NP_060434                                                              16    5631
NP_001180444                                                           16    5631
XP_006712111                                                           16    5631
XP_006712110                                                           16    5631
XP_006712109                                                           16    5631
NP_000531                                                              16    7355
NP_001036188                                                           16    7355
NP_001158238                                                           16    7355
NP_116176                                                              16    7355
NP_008816                                                              16    7355
NP_443152                                                              16    7355
XP_006723382                                                           16    7355
XP_006723381                                                           16    7355
XP_006723380                                                           16    7355
XP_005256014                                                           16    7355
XP_005247896                                                           16    7355
XP_006713857                                                           16    7355
XP_006711992                                                           16    7355
NP_803237                                                              16    7355
NP_115605                                                              15    9605
>NP_006197
          Length = 1089

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLVSTLTVP 9
           KLV TLTVP
Sbjct: 270 KLVYTLTVP 278
>XP_006714104
          Length = 832

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLVSTLTVP 9
           KLV TLTVP
Sbjct: 295 KLVYTLTVP 303
>XP_005265800
          Length = 1089

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLVSTLTVP 9
           KLV TLTVP
Sbjct: 270 KLVYTLTVP 278
>XP_006714103
          Length = 1111

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLVSTLTVP 9
           KLV TLTVP
Sbjct: 292 KLVYTLTVP 300
>XP_006714102
          Length = 1114

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLVSTLTVP 9
           KLV TLTVP
Sbjct: 295 KLVYTLTVP 303
>NP_004357
          Length = 898

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           L+STLT P
Sbjct: 373 LISTLTFP 380
>NP_001164560
          Length = 869

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           L+STLT P
Sbjct: 373 LISTLTFP 380
>NP_001164559
          Length = 854

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           L+STLT P
Sbjct: 329 LISTLTFP 336
>NP_001164558
          Length = 881

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           L+STLT P
Sbjct: 373 LISTLTFP 380
>NP_005968
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSTLTVP 9
           VST+TVP
Sbjct: 457 VSTITVP 463
>NP_036430
          Length = 1119

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVSTLTVP 9
           KL+S LT P
Sbjct: 683 KLISLLTAP 691
>NP_898865
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSTLTVP 9
           VST+TVP
Sbjct: 457 VSTITVP 463
>NP_898864
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSTLTVP 9
           VST+TVP
Sbjct: 457 VSTITVP 463
>XP_005266543
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSTLTVP 9
           VST+TVP
Sbjct: 457 VSTITVP 463
>XP_005266542
          Length = 685

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VSTLTVP 9
           VST+TVP
Sbjct: 457 VSTITVP 463
>XP_006713552
          Length = 863

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           L+STLT P
Sbjct: 373 LISTLTFP 380
>XP_006713551
          Length = 872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           L+STLT P
Sbjct: 347 LISTLTFP 354
>NP_001155971
          Length = 1236

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVSTLTVP 9
           KL+S LT P
Sbjct: 776 KLISLLTAP 784
>NP_001180442
          Length = 501

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 363 LVSTLTV 369
>NP_001180443
          Length = 438

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 300 LVSTLTV 306
>NP_060434
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 323 LVSTLTV 329
>NP_001180444
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 294 LVSTLTV 300
>XP_006712111
          Length = 264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 126 LVSTLTV 132
>XP_006712110
          Length = 387

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 249 LVSTLTV 255
>XP_006712109
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 2   LVSTLTV 8
           LVSTLTV
Sbjct: 307 LVSTLTV 313
>NP_000531
          Length = 5038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KLVSTLTV 8
            KLVSTL V
Sbjct: 1843 KLVSTLLV 1850
>NP_001036188
          Length = 5033

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KLVSTLTV 8
            KLVSTL V
Sbjct: 1843 KLVSTLLV 1850
>NP_001158238
          Length = 2789

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLVSTLTVP 9
           KL+ T+T P
Sbjct: 370 KLIMTVTTP 378
>NP_116176
          Length = 797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KLVSTLTV 8
           K+VSTL+V
Sbjct: 669 KIVSTLSV 676
>NP_008816
          Length = 3703

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KLVSTLTVP 9
            KL+ T+T P
Sbjct: 1284 KLIMTVTTP 1292
>NP_443152
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           LVS +TVP
Sbjct: 665 LVSRMTVP 672
>XP_006723382
          Length = 5027

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KLVSTLTV 8
            KLVSTL V
Sbjct: 1843 KLVSTLLV 1850
>XP_006723381
          Length = 5031

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KLVSTLTV 8
            KLVSTL V
Sbjct: 1842 KLVSTLLV 1849
>XP_006723380
          Length = 5032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KLVSTLTV 8
            KLVSTL V
Sbjct: 1843 KLVSTLLV 1850
>XP_005256014
          Length = 3702

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KLVSTLTVP 9
            KL+ T+T P
Sbjct: 1283 KLIMTVTTP 1291
>XP_005247896
          Length = 502

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KLVSTLTV 8
           K+VSTL+V
Sbjct: 374 KIVSTLSV 381
>XP_006713857
          Length = 560

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1   KLVSTLTV 8
           K+VSTL+V
Sbjct: 432 KIVSTLSV 439
>XP_006711992
          Length = 875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LVSTLTVP 9
           LVS +TVP
Sbjct: 665 LVSRMTVP 672
>NP_803237
          Length = 826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  STLTVP 9
          STLTVP
Sbjct: 74 STLTVP 79
>NP_115605
          Length = 841

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KLVSTLTVP 9
          K+VS ++VP
Sbjct: 54 KMVSEISVP 62
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.127    0.328 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 327,904
Number of extensions: 614
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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