Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001239049                                                           17    4312
NP_055963                                                              17    4312
NP_001239053                                                           17    4312
NP_001239051                                                           17    4312
NP_001239048                                                           17    4312
XP_005247048                                                           17    4312
XP_005247047                                                           17    4312
XP_006725868                                                           16    5631
XP_006725749                                                           16    5631
NP_056127                                                              16    7355
XP_006714407                                                           16    7355
XP_006714406                                                           16    7355
XP_006714405                                                           16    7355
XP_005263349                                                           16    7355
XP_005263348                                                           16    7355
XP_005263347                                                           16    7355
XP_005263346                                                           16    7355
XP_005263345                                                           16    7355
XP_005263344                                                           16    7355
XP_005263343                                                           16    7355
XP_005263342                                                           16    7355
XP_005263341                                                           16    7355
XP_005263340                                                           16    7355
XP_005263339                                                           16    7355
NP_006436                                                              15    9605
NP_001073932                                                           15    9605
NP_001368                                                              15    9605
NP_612201                                                              15    9605
XP_006721797                                                           15    9605
XP_006721796                                                           15    9605
XP_006718966                                                           15    9605
>NP_001239049
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KLVMESHSS 9
            +LVME H S
Sbjct: 1078 QLVMEKHGS 1086
>NP_055963
          Length = 1323

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KLVMESHSS 9
            +LVME H S
Sbjct: 1078 QLVMEKHGS 1086
>NP_001239053
          Length = 1143

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KLVMESHSS 9
            +LVME H S
Sbjct: 1078 QLVMEKHGS 1086
>NP_001239051
          Length = 1288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KLVMESHSS 9
            +LVME H S
Sbjct: 1043 QLVMEKHGS 1051
>NP_001239048
          Length = 1330

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KLVMESHSS 9
            +LVME H S
Sbjct: 1078 QLVMEKHGS 1086
>XP_005247048
          Length = 1107

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVMESHSS 9
           +LVME H S
Sbjct: 862 QLVMEKHGS 870
>XP_005247047
          Length = 1137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLVMESHSS 9
           +LVME H S
Sbjct: 892 QLVMEKHGS 900
>XP_006725868
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VMESHSS 9
          +M+SHSS
Sbjct: 23 IMQSHSS 29
>XP_006725749
          Length = 315

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VMESHSS 9
          +M+SHSS
Sbjct: 23 IMQSHSS 29
>NP_056127
          Length = 5005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_006714407
          Length = 5004

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3056 KYIMEEHDS 3064
>XP_006714406
          Length = 3680

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_006714405
          Length = 4103

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 2134 KYIMEEHDS 2142
>XP_005263349
          Length = 4410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 2441 KYIMEEHDS 2449
>XP_005263348
          Length = 4443

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 2474 KYIMEEHDS 2482
>XP_005263347
          Length = 4640

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_005263346
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3014 KYIMEEHDS 3022
>XP_005263345
          Length = 4991

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_005263344
          Length = 5005

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_005263343
          Length = 5009

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3040 KYIMEEHDS 3048
>XP_005263342
          Length = 5025

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3056 KYIMEEHDS 3064
>XP_005263341
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_005263340
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>XP_005263339
          Length = 5026

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KLVMESHSS 9
            K +ME H S
Sbjct: 3057 KYIMEEHDS 3065
>NP_006436
          Length = 2335

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLVMESH 7
           KLV++SH
Sbjct: 555 KLVVDSH 561
>NP_001073932
          Length = 4314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KLVMESH 7
            +L+MESH
Sbjct: 1019 ELMMESH 1025
>NP_001368
          Length = 4307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KLVMESH 7
            +L+MESH
Sbjct: 1019 ELMMESH 1025
>NP_612201
          Length = 404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VMESHSS 9
          ++ESHSS
Sbjct: 62 LLESHSS 68
>XP_006721797
          Length = 362

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VMESHSS 9
          ++ESHSS
Sbjct: 20 LLESHSS 26
>XP_006721796
          Length = 396

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  VMESHSS 9
          ++ESHSS
Sbjct: 54 LLESHSS 60
>XP_006718966
          Length = 4300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KLVMESH 7
            +L+MESH
Sbjct: 1019 ELMMESH 1025
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.107    0.254 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 565,068
Number of extensions: 688
Number of successful extensions: 31
Number of sequences better than 10000.0: 31
Number of HSP's gapped: 31
Number of HSP's successfully gapped: 31
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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