Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138390                                                           21     175
NP_001138386                                                           21     175
NP_001138387                                                           21     175
NP_000132                                                              21     175
NP_075259                                                              21     175
NP_001138388                                                           21     175
NP_001138391                                                           21     175
NP_001138385                                                           21     175
NP_075418                                                              21     175
XP_006717776                                                           21     175
XP_006717775                                                           21     175
XP_006717774                                                           21     175
XP_006717773                                                           21     175
XP_006717772                                                           21     175
XP_006717771                                                           21     175
NP_001171486                                                           17    4312
NP_001171487                                                           17    4312
XP_005246753                                                           17    4312
XP_005246752                                                           17    4312
XP_005246751                                                           17    4312
XP_006712706                                                           17    4312
XP_006712705                                                           17    4312
XP_006712704                                                           17    4312
XP_005246750                                                           17    4312
NP_071341                                                              17    4312
NP_114032                                                              16    5631
NP_004492                                                              16    5631
NP_006286                                                              16    5631
XP_005275347                                                           16    5631
XP_005275078                                                           16    5631
XP_005272926                                                           16    5631
XP_005274943                                                           16    5631
XP_005249419                                                           16    5631
NP_060469                                                              16    5631
NP_001122391                                                           16    7355
NP_722576                                                              16    7355
XP_005262424                                                           16    7355
NP_113605                                                              15    9605
NP_001243757                                                           15    9605
NP_001269255                                                           15    9605
NP_001243756                                                           15    9605
NP_060045                                                              15    9605
NP_078898                                                              15    9605
NP_001268405                                                           15    9605
NP_055642                                                              15    9605
NP_665698                                                              15    9605
NP_001098983                                                           15    9605
XP_005256628                                                           15    9605
XP_006721556                                                           15    9605
XP_005256626                                                           15    9605
XP_006713075                                                           15    9605
XP_005264984                                                           15    9605
XP_005264983                                                           15    9605
XP_005264982                                                           15    9605
XP_005264981                                                           15    9605
XP_005264980                                                           15    9605
XP_006713074                                                           15    9605
XP_005264979                                                           15    9605
XP_005264978                                                           15    9605
XP_006712813                                                           15    9605
XP_005245703                                                           15    9605
XP_006711736                                                           15    9605
XP_005245701                                                           15    9605
XP_005245700                                                           15    9605
>NP_001138390
          Length = 704

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 302 KLTKRIPLR 310
>NP_001138386
          Length = 709

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 305 KLTKRIPLR 313
>NP_001138387
          Length = 707

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 328 KLTKRIPLR 336
>NP_000132
          Length = 821

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 417 KLTKRIPLR 425
>NP_075259
          Length = 822

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 418 KLTKRIPLR 426
>NP_001138388
          Length = 706

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 302 KLTKRIPLR 310
>NP_001138391
          Length = 680

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 329 KLTKRIPLR 337
>NP_001138385
          Length = 769

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 418 KLTKRIPLR 426
>NP_075418
          Length = 732

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 328 KLTKRIPLR 336
>XP_006717776
          Length = 806

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 436 KLTKRIPLR 444
>XP_006717775
          Length = 726

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 322 KLTKRIPLR 330
>XP_006717774
          Length = 752

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 348 KLTKRIPLR 356
>XP_006717773
          Length = 807

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 437 KLTKRIPLR 445
>XP_006717772
          Length = 838

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 436 KLTKRIPLR 444
>XP_006717771
          Length = 839

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           KLTKR+PLR
Sbjct: 437 KLTKRIPLR 445
>NP_001171486
          Length = 1118

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 228 KLTNRIPI 235
>NP_001171487
          Length = 1099

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 239 KLTNRIPI 246
>XP_005246753
          Length = 619

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 297 KLTNRIPI 304
>XP_005246752
          Length = 1117

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 239 KLTNRIPI 246
>XP_005246751
          Length = 1147

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 239 KLTNRIPI 246
>XP_006712706
          Length = 1148

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 240 KLTNRIPI 247
>XP_006712705
          Length = 1174

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 297 KLTNRIPI 304
>XP_006712704
          Length = 1204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 297 KLTNRIPI 304
>XP_005246750
          Length = 1205

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 297 KLTNRIPI 304
>NP_071341
          Length = 1088

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT R+P+
Sbjct: 228 KLTNRIPI 235
>NP_114032
          Length = 825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           K+T+++P+R
Sbjct: 339 KVTEKIPVR 347
>NP_004492
          Length = 806

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KLTKRVPLR 9
           K+T+++P+R
Sbjct: 320 KVTEKIPVR 328
>NP_006286
          Length = 1264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTKRVPLR 9
           KLT R+P R
Sbjct: 839 KLTGRLPFR 847
>XP_005275347
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTKRVPLR 9
           KLT R+P R
Sbjct: 840 KLTGRLPFR 848
>XP_005275078
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTKRVPLR 9
           KLT R+P R
Sbjct: 840 KLTGRLPFR 848
>XP_005272926
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTKRVPLR 9
           KLT R+P R
Sbjct: 840 KLTGRLPFR 848
>XP_005274943
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTKRVPLR 9
           KLT R+P R
Sbjct: 840 KLTGRLPFR 848
>XP_005249419
          Length = 1265

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTKRVPLR 9
           KLT R+P R
Sbjct: 840 KLTGRLPFR 848
>NP_060469
          Length = 1072

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KLTKRVPL 8
            KLT+ VPL
Sbjct: 1056 KLTEEVPL 1063
>NP_001122391
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLTKRVP 7
           KLT+R+P
Sbjct: 611 KLTRRLP 617
>NP_722576
          Length = 3080

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTKRVPL 8
            LT+R+PL
Sbjct: 2613 LTERIPL 2619
>XP_005262424
          Length = 2875

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LTKRVPL 8
            LT+R+PL
Sbjct: 2408 LTERIPL 2414
>NP_113605
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT+RV L
Sbjct: 622 KLTRRVTL 629
>NP_001243757
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LT+ VP+R
Sbjct: 492 LTRNVPVR 499
>NP_001269255
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LT+ VP+R
Sbjct: 311 LTRNVPVR 318
>NP_001243756
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LT+ VP+R
Sbjct: 492 LTRNVPVR 499
>NP_060045
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LTKRVPLR 9
            LT+ VP+R
Sbjct: 1400 LTRNVPVR 1407
>NP_078898
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT+ +PL
Sbjct: 292 KLTEMIPL 299
>NP_001268405
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT+ +PL
Sbjct: 292 KLTEMIPL 299
>NP_055642
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>NP_665698
          Length = 1320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 868 RILKRVPL 875
>NP_001098983
          Length = 1272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 820 RILKRVPL 827
>XP_005256628
          Length = 511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LT+ VP+R
Sbjct: 492 LTRNVPVR 499
>XP_006721556
          Length = 1357

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LTKRVPLR 9
            LT+ VP+R
Sbjct: 1338 LTRNVPVR 1345
>XP_005256626
          Length = 1388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LTKRVPLR 9
            LT+ VP+R
Sbjct: 1369 LTRNVPVR 1376
>XP_006713075
          Length = 1019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 861 RILKRVPL 868
>XP_005264984
          Length = 1140

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 674 RILKRVPL 681
>XP_005264983
          Length = 1209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 743 RILKRVPL 750
>XP_005264982
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 820 RILKRVPL 827
>XP_005264981
          Length = 1290

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 824 RILKRVPL 831
>XP_005264980
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 861 RILKRVPL 868
>XP_006713074
          Length = 1318

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 861 RILKRVPL 868
>XP_005264979
          Length = 1322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 861 RILKRVPL 868
>XP_005264978
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           ++ KRVPL
Sbjct: 861 RILKRVPL 868
>XP_006712813
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTKRVPL 8
           KLT+ +PL
Sbjct: 269 KLTEMIPL 276
>XP_005245703
          Length = 474

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LTKR+P +
Sbjct: 272 LTKRLPTK 279
>XP_006711736
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>XP_005245701
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
>XP_005245700
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LTKRVPLR 9
           LTKR+P +
Sbjct: 608 LTKRLPTK 615
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.327    0.142    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 546,897
Number of extensions: 779
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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