Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              19     665
XP_005266703                                                           19     665
NP_001243779                                                           18    1135
NP_596869                                                              18    1135
XP_006712787                                                           18    1135
XP_006712786                                                           18    1135
NP_001254479                                                           18    1135
NP_001599                                                              17    2528
NP_116161                                                              17    2528
XP_005246574                                                           17    2528
NP_056520                                                              17    3301
XP_005276377                                                           17    3301
XP_005261636                                                           17    3301
XP_005261634                                                           17    3301
XP_005261632                                                           17    3301
XP_005261631                                                           17    3301
XP_005261630                                                           17    3301
XP_005261629                                                           17    3301
NP_001229326                                                           17    4312
NP_002813                                                              17    4312
NP_000897                                                              17    4312
XP_005245275                                                           17    4312
XP_006711406                                                           17    4312
XP_006711405                                                           17    4312
NP_006454                                                              16    5631
NP_998787                                                              16    5631
NP_964010                                                              16    5631
XP_005264148                                                           16    5631
XP_005264145                                                           16    5631
XP_006711984                                                           16    5631
XP_006711983                                                           16    5631
NP_078948                                                              16    7355
XP_006721518                                                           16    7355
XP_005263278                                                           16    7355
XP_005263277                                                           16    7355
NP_653303                                                              15    9605
NP_006759                                                              15    9605
NP_699181                                                              15    9605
NP_001265246                                                           15    9605
NP_004681                                                              15    9605
NP_001010906                                                           15    9605
NP_055387                                                              15    9605
NP_036436                                                              15    9605
XP_005255189                                                           15    9605
XP_005266399                                                           15    9605
XP_005254001                                                           15    9605
XP_005273560                                                           15    9605
XP_005273559                                                           15    9605
XP_005273558                                                           15    9605
XP_006715666                                                           15    9605
XP_005248330                                                           15    9605
XP_006711253                                                           15    9605
XP_006711252                                                           15    9605
XP_006711251                                                           15    9605
XP_006711248                                                           15    9605
XP_005244983                                                           15    9605
>NP_443179
          Length = 2170

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLTDVGIET 9
            KLTDVGI T
Sbjct: 2087 KLTDVGIAT 2095
>XP_005266703
          Length = 1501

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLTDVGIET 9
            KLTDVGI T
Sbjct: 1418 KLTDVGIAT 1426
>NP_001243779
          Length = 34350

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    KLTDVGIE 8
            +LTDVGIE
Sbjct: 5285 RLTDVGIE 5292
>NP_596869
          Length = 33423

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    KLTDVGIE 8
            +LTDVGIE
Sbjct: 4358 RLTDVGIE 4365
>XP_006712787
          Length = 33978

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    KLTDVGIE 8
            +LTDVGIE
Sbjct: 5286 RLTDVGIE 5293
>XP_006712786
          Length = 35484

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    KLTDVGIE 8
            +LTDVGIE
Sbjct: 5286 RLTDVGIE 5293
>NP_001254479
          Length = 35991

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1    KLTDVGIE 8
            +LTDVGIE
Sbjct: 5602 RLTDVGIE 5609
>NP_001599
          Length = 430

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KLTDVGI 7
          KLTD+GI
Sbjct: 43 KLTDIGI 49
>NP_116161
          Length = 646

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           KL+D+G+E
Sbjct: 163 KLSDIGVE 170
>XP_005246574
          Length = 409

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KLTDVGI 7
          KLTD+GI
Sbjct: 22 KLTDIGI 28
>NP_056520
          Length = 749

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 361 LTDVAVET 368
>XP_005276377
          Length = 328

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  TDVGIET 9
          TD+G+ET
Sbjct: 23 TDIGLET 29
>XP_005261636
          Length = 596

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 294 LTDVAVET 301
>XP_005261634
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 361 LTDVAVET 368
>XP_005261632
          Length = 699

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 294 LTDVAVET 301
>XP_005261631
          Length = 739

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 361 LTDVAVET 368
>XP_005261630
          Length = 756

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 361 LTDVAVET 368
>XP_005261629
          Length = 766

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LTDVGIET 9
           LTDV +ET
Sbjct: 361 LTDVAVET 368
>NP_001229326
          Length = 357

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TDVGIET 9
           TDVG++T
Sbjct: 171 TDVGVDT 177
>NP_002813
          Length = 350

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TDVGIET 9
           TDVG++T
Sbjct: 164 TDVGVDT 170
>NP_000897
          Length = 1061

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+TD G+E+
Sbjct: 675 KITDYGLES 683
>XP_005245275
          Length = 1035

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+TD G+E+
Sbjct: 649 KITDYGLES 657
>XP_006711406
          Length = 1036

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+TD G+E+
Sbjct: 650 KITDYGLES 658
>XP_006711405
          Length = 1062

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+TD G+E+
Sbjct: 676 KITDYGLES 684
>NP_006454
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 378 KLTDHGLE 385
>NP_998787
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 378 KLTDHGLE 385
>NP_964010
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 378 KLTDHGLE 385
>XP_005264148
          Length = 289

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 243 KLTDHGLE 250
>XP_005264145
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 378 KLTDHGLE 385
>XP_006711984
          Length = 457

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 425 KLTDHGLE 432
>XP_006711983
          Length = 471

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           KLTD G+E
Sbjct: 425 KLTDHGLE 432
>NP_078948
          Length = 903

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLTDVGI 7
           KL+D+GI
Sbjct: 360 KLSDIGI 366
>XP_006721518
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   LTDVGI 7
           LTDVGI
Sbjct: 339 LTDVGI 344
>XP_005263278
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  KLTDVGI 7
          KL+D+GI
Sbjct: 77 KLSDIGI 83
>XP_005263277
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLTDVGI 7
           KL+D+GI
Sbjct: 216 KLSDIGI 222
>NP_653303
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           ++T+VG+E
Sbjct: 483 RITEVGLE 490
>NP_006759
          Length = 592

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  KLTDVGIET 9
          ++TDV IET
Sbjct: 68 EMTDVIIET 76
>NP_699181
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           K+TD G+E
Sbjct: 332 KVTDDGVE 339
>NP_001265246
          Length = 444

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLTDVGI 7
           ++TDVGI
Sbjct: 315 RVTDVGI 321
>NP_004681
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTDVGIET 9
           KLTD G+ T
Sbjct: 843 KLTDFGLCT 851
>NP_001010906
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+T++GI +
Sbjct: 613 KMTEIGIRS 621
>NP_055387
          Length = 1088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTDVGIET 9
           KLTD G+ T
Sbjct: 806 KLTDFGLCT 814
>NP_036436
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLTDVGI 7
           ++TDVGI
Sbjct: 362 RVTDVGI 368
>XP_005255189
          Length = 479

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLTDVGIE 8
           K+TD G+E
Sbjct: 332 KVTDDGVE 339
>XP_005266399
          Length = 1088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTDVGIET 9
           KLTD G+ T
Sbjct: 806 KLTDFGLCT 814
>XP_005254001
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           ++TDV IET
Sbjct: 109 EMTDVIIET 117
>XP_005273560
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+T++GI +
Sbjct: 489 KMTEIGIRS 497
>XP_005273559
          Length = 701

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+T++GI +
Sbjct: 518 KMTEIGIRS 526
>XP_005273558
          Length = 796

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLTDVGIET 9
           K+T++GI +
Sbjct: 613 KMTEIGIRS 621
>XP_006715666
          Length = 886

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLTDVGIET 9
           KLTD G+ T
Sbjct: 843 KLTDFGLCT 851
>XP_005248330
          Length = 486

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLTDVGI 7
           ++TDVGI
Sbjct: 357 RVTDVGI 363
>XP_006711253
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           ++T+VG+E
Sbjct: 269 RITEVGLE 276
>XP_006711252
          Length = 345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           ++T+VG+E
Sbjct: 269 RITEVGLE 276
>XP_006711251
          Length = 466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           ++T+VG+E
Sbjct: 390 RITEVGLE 397
>XP_006711248
          Length = 533

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           ++T+VG+E
Sbjct: 457 RITEVGLE 464
>XP_005244983
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLTDVGIE 8
           ++T+VG+E
Sbjct: 484 RITEVGLE 491
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.134    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 434,660
Number of extensions: 812
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package