Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     509
NP_005913                                                              20     509
XP_005267046                                                           20     509
XP_005267045                                                           20     509
NP_078863                                                              16    7355
NP_001245221                                                           16    7355
NP_001129493                                                           16    7355
NP_001363                                                              16    7355
XP_006721530                                                           16    7355
XP_006721529                                                           16    7355
XP_006721528                                                           16    7355
XP_005271253                                                           16    7355
XP_005271252                                                           16    7355
XP_005271251                                                           16    7355
NP_055032                                                              15    9605
NP_078988                                                              15    9605
NP_001017425                                                           15    9605
NP_001017424                                                           15    9605
>NP_006715
          Length = 1558

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLRIMGTVV 9
           KLRIMGTV+
Sbjct: 406 KLRIMGTVL 414
>NP_005913
          Length = 1608

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLRIMGTVV 9
           KLRIMGTV+
Sbjct: 406 KLRIMGTVL 414
>XP_005267046
          Length = 1554

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLRIMGTVV 9
           KLRIMGTV+
Sbjct: 406 KLRIMGTVL 414
>XP_005267045
          Length = 1604

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLRIMGTVV 9
           KLRIMGTV+
Sbjct: 406 KLRIMGTVL 414
>NP_078863
          Length = 277

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLRIMGTV 8
           +LR++GT+
Sbjct: 134 RLRVVGTI 141
>NP_001245221
          Length = 905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LRIMGTV 8
          LRIMG+V
Sbjct: 15 LRIMGSV 21
>NP_001129493
          Length = 901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LRIMGTV 8
          LRIMG+V
Sbjct: 15 LRIMGSV 21
>NP_001363
          Length = 4486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KLRIMGTVV 9
          +LR++GT V
Sbjct: 24 RLRLLGTYV 32
>XP_006721530
          Length = 2746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KLRIMGTVV 9
          +LR++GT V
Sbjct: 24 RLRLLGTYV 32
>XP_006721529
          Length = 2817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KLRIMGTVV 9
          +LR++GT V
Sbjct: 24 RLRLLGTYV 32
>XP_006721528
          Length = 3869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KLRIMGTVV 9
          +LR++GT V
Sbjct: 24 RLRLLGTYV 32
>XP_005271253
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KLRIMGTV 8
          +LR++GT+
Sbjct: 61 RLRVVGTI 68
>XP_005271252
          Length = 246

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLRIMGTV 8
           +LR++GT+
Sbjct: 103 RLRVVGTI 110
>XP_005271251
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KLRIMGTV 8
           +LR++GT+
Sbjct: 104 RLRVVGTI 111
>NP_055032
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLRIMGTVV 9
           K+RI+ T++
Sbjct: 205 KIRIISTII 213
>NP_078988
          Length = 773

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LRIMGTVV 9
           L+I+GT++
Sbjct: 179 LQILGTII 186
>NP_001017425
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLRIMGTVV 9
           K+RI+ T++
Sbjct: 220 KIRIISTII 228
>NP_001017424
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KLRIMGTVV 9
           K+RI+ T++
Sbjct: 216 KIRIISTII 224
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.148    0.388 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 368,716
Number of extensions: 468
Number of successful extensions: 18
Number of sequences better than 10000.0: 18
Number of HSP's gapped: 18
Number of HSP's successfully gapped: 18
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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