Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055491                                                              16    5631
NP_001018494                                                           16    5631
NP_065798                                                              16    7355
XP_005272097                                                           16    7355
XP_005272096                                                           16    7355
XP_006714725                                                           16    7355
XP_005272095                                                           16    7355
XP_005272094                                                           16    7355
NP_079052                                                              15    9605
NP_597721                                                              15    9605
NP_001103132                                                           15    9605
NP_001269166                                                           15    9605
NP_001269167                                                           15    9605
NP_203751                                                              15    9605
NP_075049                                                              15    9605
NP_002190                                                              15    9605
NP_001138648                                                           15    9605
NP_001273551                                                           15    9605
NP_612808                                                              15    9605
XP_005254732                                                           15    9605
XP_005254731                                                           15    9605
XP_006720754                                                           15    9605
XP_005254729                                                           15    9605
XP_005254730                                                           15    9605
XP_005254728                                                           15    9605
XP_005254727                                                           15    9605
XP_006714457                                                           15    9605
XP_006714456                                                           15    9605
XP_005263376                                                           15    9605
XP_005263043                                                           15    9605
XP_005263041                                                           15    9605
NP_001005174                                                           15    9605
>NP_055491
          Length = 1186

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KLMSSSLTP 9
           K  SSSLTP
Sbjct: 718 KRTSSSLTP 726
>NP_001018494
          Length = 1188

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   KLMSSSLTP 9
           K  SSSLTP
Sbjct: 718 KRTSSSLTP 726
>NP_065798
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSSLTP
Sbjct: 316 ISSSLTP 322
>XP_005272097
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  MSSSLTP 9
          +SSSLTP
Sbjct: 28 ISSSLTP 34
>XP_005272096
          Length = 1511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSSLTP
Sbjct: 316 ISSSLTP 322
>XP_006714725
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSSLTP
Sbjct: 316 ISSSLTP 322
>XP_005272095
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSSLTP
Sbjct: 316 ISSSLTP 322
>XP_005272094
          Length = 1512

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSSLTP
Sbjct: 316 ISSSLTP 322
>NP_079052
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>NP_597721
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 479 SSSLTP 484
>NP_001103132
          Length = 4284

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    SSSLTP 9
            SSSLTP
Sbjct: 3340 SSSLTP 3345
>NP_001269166
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 255 SSSLTP 260
>NP_001269167
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 184 SSSLTP 189
>NP_203751
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 721 SSSLTP 726
>NP_075049
          Length = 823

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 185 SSSLTP 190
>NP_002190
          Length = 349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSS+TP
Sbjct: 313 LSSSMTP 319
>NP_001138648
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 245 SSSLTP 250
>NP_001273551
          Length = 136

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SSSLTP 9
          SSSLTP
Sbjct: 5  SSSLTP 10
>NP_612808
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 256 SSSLTP 261
>XP_005254732
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_005254731
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_006720754
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_005254729
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_005254730
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_005254728
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_005254727
          Length = 1746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 511 SSSLTP 516
>XP_006714457
          Length = 809

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 387 SSSLTP 392
>XP_006714456
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 721 SSSLTP 726
>XP_005263376
          Length = 1143

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SSSLTP 9
           SSSLTP
Sbjct: 721 SSSLTP 726
>XP_005263043
          Length = 187

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSS+TP
Sbjct: 151 LSSSMTP 157
>XP_005263041
          Length = 347

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MSSSLTP 9
           +SSS+TP
Sbjct: 311 LSSSMTP 317
>NP_001005174
          Length = 321

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  SSSLTP 9
          SSSLTP
Sbjct: 6  SSSLTP 11
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.301    0.111    0.270 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 352,304
Number of extensions: 456
Number of successful extensions: 32
Number of sequences better than 10000.0: 32
Number of HSP's gapped: 32
Number of HSP's successfully gapped: 32
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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