Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              18    1935
NP_001035957                                                           18    1935
XP_006721991                                                           18    1935
XP_006721990                                                           18    1935
XP_006721989                                                           18    1935
XP_005258041                                                           18    1935
XP_006721988                                                           18    1935
XP_006721987                                                           18    1935
XP_006721986                                                           18    1935
XP_005258040                                                           18    1935
XP_006721985                                                           18    1935
NP_001036216                                                           16    5631
NP_001036214                                                           16    5631
NP_006594                                                              16    5631
NP_001036215                                                           16    5631
NP_001269347                                                           16    5631
NP_001273574                                                           16    5631
NP_001110                                                              16    5631
NP_054909                                                              16    5631
NP_054908                                                              16    5631
NP_789771                                                              16    5631
XP_006724791                                                           16    5631
XP_005262418                                                           16    5631
XP_005262417                                                           16    5631
XP_005262416                                                           16    5631
XP_005262415                                                           16    5631
XP_006724790                                                           16    5631
XP_005262414                                                           16    5631
XP_005247994                                                           16    5631
XP_005247993                                                           16    5631
XP_005247992                                                           16    5631
XP_005247991                                                           16    5631
XP_005247990                                                           16    5631
>NP_000258
          Length = 2818

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1419 KLMSKILQS 1427
>NP_001035957
          Length = 2839

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1440 KLMSKILQS 1448
>XP_006721991
          Length = 1632

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1450 KLMSKILQS 1458
>XP_006721990
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1450 KLMSKILQS 1458
>XP_006721989
          Length = 2823

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1450 KLMSKILQS 1458
>XP_005258041
          Length = 2836

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1419 KLMSKILQS 1427
>XP_006721988
          Length = 2846

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1429 KLMSKILQS 1437
>XP_006721987
          Length = 2849

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1450 KLMSKILQS 1458
>XP_006721986
          Length = 2854

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1437 KLMSKILQS 1445
>XP_005258040
          Length = 2857

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1440 KLMSKILQS 1448
>XP_006721985
          Length = 2867

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KLMSMILQS 9
            KLMS ILQS
Sbjct: 1450 KLMSKILQS 1458
>NP_001036216
          Length = 1231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>NP_001036214
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>NP_006594
          Length = 1231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>NP_001036215
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>NP_001269347
          Length = 1231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>NP_001273574
          Length = 662

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>NP_001110
          Length = 737

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>NP_054909
          Length = 631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>NP_054908
          Length = 768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>NP_789771
          Length = 662

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>XP_006724791
          Length = 1199

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 323 KLLTLVLQS 331
>XP_005262418
          Length = 1231

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>XP_005262417
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>XP_005262416
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>XP_005262415
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>XP_006724790
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>XP_005262414
          Length = 1268

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLMSMILQS 9
           KL++++LQS
Sbjct: 392 KLLTLVLQS 400
>XP_005247994
          Length = 662

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>XP_005247993
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>XP_005247992
          Length = 768

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>XP_005247991
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
>XP_005247990
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  KLMSMILQS 9
          K +SMILQS
Sbjct: 56 KRVSMILQS 64
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.328    0.128    0.284 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 202,767
Number of extensions: 226
Number of successful extensions: 33
Number of sequences better than 10000.0: 33
Number of HSP's gapped: 33
Number of HSP's successfully gapped: 33
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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