Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              18    1482
NP_001075109                                                           18    1482
NP_057531                                                              18    1935
XP_005249832                                                           18    1935
XP_006715803                                                           18    1935
XP_006715802                                                           18    1935
XP_006715801                                                           18    1935
NP_000360                                                              17    2528
XP_005268094                                                           17    2528
NP_060485                                                              17    3301
NP_001171711                                                           17    3301
NP_852111                                                              17    4312
NP_000136                                                              17    4312
NP_001167554                                                           17    4312
NP_001167553                                                           17    4312
NP_060322                                                              17    4312
NP_001167552                                                           17    4312
NP_008880                                                              16    5631
NP_001258963                                                           16    5631
NP_001120868                                                           16    5631
XP_006722914                                                           16    5631
NP_001087199                                                           16    5631
NP_001127923                                                           16    7355
NP_001127922                                                           16    7355
NP_690877                                                              16    7355
NP_002842                                                              16    7355
NP_001193767                                                           16    7355
XP_006716139                                                           16    7355
XP_005250576                                                           16    7355
NP_001193768                                                           16    7355
NP_001128302                                                           15    9605
NP_060121                                                              15    9605
NP_001128303                                                           15    9605
NP_001128304                                                           15    9605
NP_001156909                                                           15    9605
NP_149106                                                              15    9605
NP_001156908                                                           15    9605
NP_001277697                                                           15    9605
NP_001156907                                                           15    9605
NP_071431                                                              15    9605
NP_000048                                                              15    9605
NP_001274177                                                           15    9605
NP_001274176                                                           15    9605
NP_001274175                                                           15    9605
NP_653259                                                              15    9605
XP_005262426                                                           15    9605
XP_005262425                                                           15    9605
XP_006720695                                                           15    9605
XP_005267096                                                           15    9605
XP_006715570                                                           15    9605
>NP_008835
          Length = 4128

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLL ITVRN
Sbjct: 668 KLLSITVRN 676
>NP_001075109
          Length = 4097

 Score = 18.1 bits (35), Expect =  1482
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLL ITVRN
Sbjct: 668 KLLSITVRN 676
>NP_057531
          Length = 540

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           K++Y+T RN
Sbjct: 308 KMMYLTTRN 316
>XP_005249832
          Length = 428

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           K++Y+T RN
Sbjct: 196 KMMYLTTRN 204
>XP_006715803
          Length = 540

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           K++Y+T RN
Sbjct: 308 KMMYLTTRN 316
>XP_006715802
          Length = 540

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           K++Y+T RN
Sbjct: 308 KMMYLTTRN 316
>XP_006715801
          Length = 540

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           K++Y+T RN
Sbjct: 308 KMMYLTTRN 316
>NP_000360
          Length = 764

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LYITVRN 9
           +YITVRN
Sbjct: 604 IYITVRN 610
>XP_005268094
          Length = 764

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LYITVRN 9
           +YITVRN
Sbjct: 604 IYITVRN 610
>NP_060485
          Length = 855

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLLY+T  N
Sbjct: 454 KLLYLTTTN 462
>NP_001171711
          Length = 758

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLLY+T  N
Sbjct: 454 KLLYLTTTN 462
>NP_852111
          Length = 669

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LYITVRN 9
           +Y+TVRN
Sbjct: 526 IYLTVRN 532
>NP_000136
          Length = 695

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LYITVRN 9
           +Y+TVRN
Sbjct: 552 IYLTVRN 558
>NP_001167554
          Length = 1039

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLLY T+R+
Sbjct: 806 KLLYTTLRH 814
>NP_001167553
          Length = 1040

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLLY T+R+
Sbjct: 807 KLLYTTLRH 815
>NP_060322
          Length = 1062

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLLY T+R+
Sbjct: 829 KLLYTTLRH 837
>NP_001167552
          Length = 1062

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLLY T+R+
Sbjct: 829 KLLYTTLRH 837
>NP_008880
          Length = 593

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLYITVRN 9
           LLYI +RN
Sbjct: 408 LLYILLRN 415
>NP_001258963
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLYITVRN 9
           LLYI +RN
Sbjct: 419 LLYILLRN 426
>NP_001120868
          Length = 590

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLYITVRN 9
           LLYI +RN
Sbjct: 405 LLYILLRN 412
>XP_006722914
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLYITVRN 9
           LLYI +RN
Sbjct: 381 LLYILLRN 388
>NP_001087199
          Length = 578

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLYITVRN 9
           KLL+ T+RN
Sbjct: 285 KLLFRTLRN 293
>NP_001127923
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LLYITVRN 9
           ++Y+T+RN
Sbjct: 255 IMYMTLRN 262
>NP_001127922
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LLYITVRN 9
           ++Y+T+RN
Sbjct: 357 IMYMTLRN 364
>NP_690877
          Length = 423

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   LLYITVRN 9
           ++Y+T+RN
Sbjct: 357 IMYMTLRN 364
>NP_002842
          Length = 2315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LLYITVRN 9
            L Y TVRN
Sbjct: 1862 LAYYTVRN 1869
>NP_001193767
          Length = 1455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LLYITVRN 9
            L Y TVRN
Sbjct: 1002 LAYYTVRN 1009
>XP_006716139
          Length = 1869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LLYITVRN 9
            L Y TVRN
Sbjct: 1416 LAYYTVRN 1423
>XP_005250576
          Length = 2308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LLYITVRN 9
            L Y TVRN
Sbjct: 1855 LAYYTVRN 1862
>NP_001193768
          Length = 1448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LLYITVRN 9
            L Y TVRN
Sbjct: 995  LAYYTVRN 1002
>NP_001128302
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LYITVR 8
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_060121
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LYITVR 8
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_001128303
          Length = 1196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LYITVR 8
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_001128304
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LYITVR 8
           LY+TVR
Sbjct: 530 LYVTVR 535
>NP_001156909
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLL + +RN
Sbjct: 754 KLLVVDIRN 762
>NP_149106
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLL + +RN
Sbjct: 730 KLLVVDIRN 738
>NP_001156908
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLL + +RN
Sbjct: 793 KLLVVDIRN 801
>NP_001277697
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLL + +RN
Sbjct: 621 KLLVVDIRN 629
>NP_001156907
          Length = 893

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLLYITVRN 9
           KLL + +RN
Sbjct: 793 KLLVVDIRN 801
>NP_071431
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LLYITVRN 9
           +LY ++RN
Sbjct: 94  ILYFSIRN 101
>NP_000048
          Length = 1417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLLYIT 6
           KLLY+T
Sbjct: 761 KLLYVT 766
>NP_001274177
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLLYIT 6
           KLLY+T
Sbjct: 386 KLLYVT 391
>NP_001274176
          Length = 1286

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLLYIT 6
           KLLY+T
Sbjct: 761 KLLYVT 766
>NP_001274175
          Length = 1417

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLLYIT 6
           KLLY+T
Sbjct: 761 KLLYVT 766
>NP_653259
          Length = 2073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLYITVRN 9
            LLY+ +RN
Sbjct: 1504 LLYLLMRN 1511
>XP_005262426
          Length = 2055

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLYITVRN 9
            LLY+ +RN
Sbjct: 1486 LLYLLMRN 1493
>XP_005262425
          Length = 2086

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LLYITVRN 9
            LLY+ +RN
Sbjct: 1517 LLYLLMRN 1524
>XP_006720695
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLLYIT 6
           KLLY+T
Sbjct: 107 KLLYVT 112
>XP_005267096
          Length = 1168

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LYITVR 8
           LY+TVR
Sbjct: 530 LYVTVR 535
>XP_006715570
          Length = 1179

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LYITVR 8
           LY+TVR
Sbjct: 530 LYVTVR 535
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.147    0.398 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 388,519
Number of extensions: 647
Number of successful extensions: 50
Number of sequences better than 10000.0: 50
Number of HSP's gapped: 50
Number of HSP's successfully gapped: 50
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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