Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           18    1135
NP_000242                                                              18    1135
XP_005264389                                                           18    1135
NP_000631                                                              17    3301
NP_694996                                                              17    4312
NP_001265227                                                           17    4312
NP_848634                                                              16    5631
XP_006723231                                                           16    5631
XP_005258877                                                           16    5631
XP_005258876                                                           16    5631
XP_006719433                                                           16    5631
NP_054756                                                              16    5631
NP_001074924                                                           16    7355
NP_066580                                                              16    7355
NP_060474                                                              16    7355
NP_001157932                                                           16    7355
XP_005253535                                                           16    7355
XP_005253534                                                           16    7355
XP_005253531                                                           16    7355
XP_006713895                                                           16    7355
XP_005247980                                                           16    7355
XP_005247979                                                           16    7355
XP_005247978                                                           16    7355
XP_005247626                                                           16    7355
XP_005247625                                                           16    7355
NP_602307                                                              16    7355
NP_055694                                                              16    7355
NP_877435                                                              15    9605
XP_005249642                                                           15    9605
XP_005249641                                                           15    9605
NP_066939                                                              15    9605
NP_001005323                                                           15    9605
NP_001028191                                                           15    9605
>NP_001245210
          Length = 868

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLLLVVFVT 9
           KLLL VFVT
Sbjct: 364 KLLLAVFVT 372
>NP_000242
          Length = 934

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLLLVVFVT 9
           KLLL VFVT
Sbjct: 430 KLLLAVFVT 438
>XP_005264389
          Length = 921

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KLLLVVFVT 9
           KLLL VFVT
Sbjct: 430 KLLLAVFVT 438
>NP_000631
          Length = 380

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           L+LV+FVT
Sbjct: 352 LILVIFVT 359
>NP_694996
          Length = 2526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 KLLLVVFV 8
         K+LL++FV
Sbjct: 2 KILLIIFV 9
>NP_001265227
          Length = 2614

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 KLLLVVFV 8
         K+LL++FV
Sbjct: 2 KILLIIFV 9
>NP_848634
          Length = 131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KLLLVVFV 8
          KLL+++F+
Sbjct: 13 KLLIIIFI 20
>XP_006723231
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           +LL++FVT
Sbjct: 621 VLLIIFVT 628
>XP_005258877
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           +LL++FVT
Sbjct: 621 VLLIIFVT 628
>XP_005258876
          Length = 818

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           +LL++FVT
Sbjct: 703 VLLIIFVT 710
>XP_006719433
          Length = 131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  KLLLVVFV 8
          KLL+++F+
Sbjct: 13 KLLIIIFI 20
>NP_054756
          Length = 736

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           +LL++FVT
Sbjct: 621 VLLIIFVT 628
>NP_001074924
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLVVFVT 9
           LLL+VF T
Sbjct: 200 LLLIVFYT 207
>NP_066580
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LLLVVFVT 9
          LLL++FV+
Sbjct: 70 LLLIIFVS 77
>NP_060474
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           L+LVVF+T
Sbjct: 156 LVLVVFLT 163
>NP_001157932
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLLLVVF 7
           KLLL++F
Sbjct: 334 KLLLIIF 340
>XP_005253535
          Length = 579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LLLVVFVT 9
          LLL++FV+
Sbjct: 68 LLLIIFVS 75
>XP_005253534
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LLLVVFVT 9
          LLL++FV+
Sbjct: 50 LLLIIFVS 57
>XP_005253531
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LLLVVFVT 9
          LLL++FV+
Sbjct: 70 LLLIIFVS 77
>XP_006713895
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLVVFVT 9
           LLL+VF T
Sbjct: 200 LLLIVFYT 207
>XP_005247980
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLVVFVT 9
           LLL+VF T
Sbjct: 200 LLLIVFYT 207
>XP_005247979
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLVVFVT 9
           LLL+VF T
Sbjct: 200 LLLIVFYT 207
>XP_005247978
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLVVFVT 9
           LLL+VF T
Sbjct: 200 LLLIVFYT 207
>XP_005247626
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           L+LVVF+T
Sbjct: 172 LVLVVFLT 179
>XP_005247625
          Length = 291

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   LLLVVFVT 9
           L+LVVF+T
Sbjct: 172 LVLVVFLT 179
>NP_602307
          Length = 670

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  LLLVVFVT 9
          LLL++FV+
Sbjct: 70 LLLIIFVS 77
>NP_055694
          Length = 338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LLLVVFVT 9
           LLL+VF T
Sbjct: 200 LLLIVFYT 207
>NP_877435
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   KLLLVVF 7
           +LLLVVF
Sbjct: 226 RLLLVVF 232
>XP_005249642
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLLVVFVT 9
           +LLLV FV+
Sbjct: 165 QLLLVTFVS 173
>XP_005249641
          Length = 979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLLVVFVT 9
           +LLLV FV+
Sbjct: 165 QLLLVTFVS 173
>NP_066939
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLLLVVFVT 9
           +LLLV FV+
Sbjct: 165 QLLLVTFVS 173
>NP_001005323
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LLLVVFV 8
           +LLVVFV
Sbjct: 197 MLLVVFV 203
>NP_001028191
          Length = 66

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1 KLLLVVFV 8
         K LLVVFV
Sbjct: 2 KPLLVVFV 9
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.348    0.160    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 321,760
Number of extensions: 537
Number of successful extensions: 33
Number of sequences better than 10000.0: 33
Number of HSP's gapped: 33
Number of HSP's successfully gapped: 33
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.7 bits)
S2: 28 (15.4 bits)

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