Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           20     299
NP_055903                                                              20     299
NP_115818                                                              17    4312
NP_001005408                                                           17    4312
NP_009041                                                              16    5631
NP_663778                                                              16    5631
NP_663777                                                              16    5631
NP_001186356                                                           16    5631
NP_003291                                                              16    5631
XP_006720307                                                           16    5631
XP_005268084                                                           16    5631
NP_653249                                                              16    5631
NP_006420                                                              16    7355
NP_001159757                                                           16    7355
NP_001129588                                                           16    7355
NP_006835                                                              16    7355
XP_005259774                                                           16    7355
XP_005265965                                                           16    7355
NP_996555                                                              15    9605
NP_001241649                                                           15    9605
NP_001241647                                                           15    9605
NP_001241650                                                           15    9605
NP_001241652                                                           15    9605
NP_002456                                                              15    9605
NP_001241651                                                           15    9605
NP_996557                                                              15    9605
NP_001241648                                                           15    9605
NP_996556                                                              15    9605
NP_001019764                                                           15    9605
NP_699193                                                              15    9605
NP_001163894                                                           15    9605
NP_001161846                                                           15    9605
NP_001161849                                                           15    9605
NP_001010986                                                           15    9605
NP_001161848                                                           15    9605
NP_001239257                                                           15    9605
NP_775965                                                              15    9605
NP_055624                                                              15    9605
NP_620138                                                              15    9605
NP_003626                                                              15    9605
NP_001161847                                                           15    9605
XP_006725000                                                           15    9605
XP_006724816                                                           15    9605
XP_006724815                                                           15    9605
XP_006724814                                                           15    9605
XP_005262462                                                           15    9605
XP_006719474                                                           15    9605
XP_005268933                                                           15    9605
XP_006719473                                                           15    9605
XP_006719472                                                           15    9605
XP_006719471                                                           15    9605
XP_006719470                                                           15    9605
XP_006719469                                                           15    9605
XP_006719468                                                           15    9605
XP_005270313                                                           15    9605
XP_005270312                                                           15    9605
XP_006718109                                                           15    9605
XP_006715351                                                           15    9605
XP_006715350                                                           15    9605
XP_006715349                                                           15    9605
XP_005249561                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLIVDGSDM 9
           K+IVDGSDM
Sbjct: 189 KVIVDGSDM 197
>NP_055903
          Length = 1723

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLIVDGSDM 9
           K+IVDGSDM
Sbjct: 189 KVIVDGSDM 197
>NP_115818
          Length = 1562

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVDGSDM 9
            ++VDG DM
Sbjct: 1050 ILVDGEDM 1057
>NP_001005408
          Length = 1560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    LIVDGSDM 9
            ++VDG DM
Sbjct: 1048 ILVDGEDM 1055
>NP_009041
          Length = 2627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LIVDGSD 8
            LI+DG+D
Sbjct: 1263 LIIDGAD 1269
>NP_663778
          Length = 543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLIVDGSDM 9
           K+IVD SD+
Sbjct: 532 KVIVDTSDL 540
>NP_663777
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLIVDGSDM 9
           K+IVD SD+
Sbjct: 557 KVIVDTSDL 565
>NP_001186356
          Length = 485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLIVDGSDM 9
           K+IVD SD+
Sbjct: 474 KVIVDTSDL 482
>NP_003291
          Length = 568

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLIVDGSDM 9
           K+IVD SD+
Sbjct: 557 KVIVDTSDL 565
>XP_006720307
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KLIVDGSDM 9
           K+IVD SD+
Sbjct: 530 KVIVDTSDL 538
>XP_005268084
          Length = 2627

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    LIVDGSD 8
            LI+DG+D
Sbjct: 1263 LIIDGAD 1269
>NP_653249
          Length = 825

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KLIVDGSDM 9
           KLI+DG+++
Sbjct: 219 KLILDGNEI 227
>NP_006420
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  KLIVDG 6
          KLIVDG
Sbjct: 47 KLIVDG 52
>NP_001159757
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1 KLIVDG 6
         KLIVDG
Sbjct: 3 KLIVDG 8
>NP_001129588
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLIVDGS 7
           KLI+DG+
Sbjct: 106 KLIIDGT 112
>NP_006835
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LIVDGSD 8
           L+VDG D
Sbjct: 464 LVVDGGD 470
>XP_005259774
          Length = 632

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LIVDGSD 8
           L+VDG D
Sbjct: 464 LVVDGGD 470
>XP_005265965
          Length = 563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KLIVDGS 7
           KLI+DG+
Sbjct: 106 KLIIDGT 112
>NP_996555
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 548 KIILDGLD 555
>NP_001241649
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 511 KIILDGLD 518
>NP_001241647
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 523 KIILDGLD 530
>NP_001241650
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 504 KIILDGLD 511
>NP_001241652
          Length = 1139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 510 KIILDGLD 517
>NP_002456
          Length = 1171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 548 KIILDGLD 555
>NP_001241651
          Length = 1120

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 497 KIILDGLD 504
>NP_996557
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 523 KIILDGLD 530
>NP_001241648
          Length = 1146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 523 KIILDGLD 530
>NP_996556
          Length = 1141

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 523 KIILDGLD 530
>NP_001019764
          Length = 460

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KLIVDG 6
          KL+VDG
Sbjct: 74 KLVVDG 79
>NP_699193
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  IVDGSDM 9
          ++DGS+M
Sbjct: 17 LIDGSEM 23
>NP_001163894
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3  IVDGSDM 9
          ++DGS+M
Sbjct: 17 LIDGSEM 23
>NP_001161846
          Length = 1063

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 757 VIDGSD 762
>NP_001161849
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 766 VIDGSD 771
>NP_001010986
          Length = 1119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LI+DGS +
Sbjct: 752 LIIDGSTL 759
>NP_001161848
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 721 VIDGSD 726
>NP_001239257
          Length = 483

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 177 VIDGSD 182
>NP_775965
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LI+DGS +
Sbjct: 752 LIIDGSTL 759
>NP_055624
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 766 VIDGSD 771
>NP_620138
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VDGSDM 9
           +DGSDM
Sbjct: 430 LDGSDM 435
>NP_003626
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LIVDG ++
Sbjct: 773 LIVDGQEL 780
>NP_001161847
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 766 VIDGSD 771
>XP_006725000
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  KLIVDGSDM 9
          +L +DGSD+
Sbjct: 58 RLSLDGSDI 66
>XP_006724816
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LI+DGS +
Sbjct: 749 LIIDGSTL 756
>XP_006724815
          Length = 1105

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LI+DGS +
Sbjct: 749 LIIDGSTL 756
>XP_006724814
          Length = 1116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LI+DGS +
Sbjct: 749 LIIDGSTL 756
>XP_005262462
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LI+DGS +
Sbjct: 749 LIIDGSTL 756
>XP_006719474
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 523 KIILDGLD 530
>XP_005268933
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 536 KIILDGLD 543
>XP_006719473
          Length = 1166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 548 KIILDGLD 555
>XP_006719472
          Length = 1170

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 523 KIILDGLD 530
>XP_006719471
          Length = 1177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 548 KIILDGLD 555
>XP_006719470
          Length = 1183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 536 KIILDGLD 543
>XP_006719469
          Length = 1189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 548 KIILDGLD 555
>XP_006719468
          Length = 1195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLIVDGSD 8
           K+I+DG D
Sbjct: 548 KIILDGLD 555
>XP_005270313
          Length = 509

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LIVDG ++
Sbjct: 399 LIVDGQEL 406
>XP_005270312
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LIVDG ++
Sbjct: 773 LIVDGQEL 780
>XP_006718109
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIVDGSDM 9
           LIVDG ++
Sbjct: 711 LIVDGQEL 718
>XP_006715351
          Length = 920

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 614 VIDGSD 619
>XP_006715350
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 828 VIDGSD 833
>XP_006715349
          Length = 1101

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 795 VIDGSD 800
>XP_005249561
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   IVDGSD 8
           ++DGSD
Sbjct: 828 VIDGSD 833
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.142    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 569,910
Number of extensions: 1214
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package