Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_065681                                                              21     229
NP_066124                                                              21     229
XP_006717999                                                           21     229
NP_008864                                                              18    1935
NP_982271                                                              17    4312
NP_001153774                                                           17    4312
NP_109592                                                              17    4312
NP_003886                                                              17    4312
NP_002839                                                              17    4312
NP_001153778                                                           17    4312
XP_005261137                                                           17    4312
XP_006724126                                                           17    4312
XP_006724125                                                           17    4312
XP_006724124                                                           17    4312
XP_005261133                                                           17    4312
XP_006724123                                                           17    4312
XP_006724122                                                           17    4312
XP_006724121                                                           17    4312
XP_006722785                                                           17    4312
NP_059976                                                              17    4312
NP_001005190                                                           17    4312
NP_001001957                                                           17    4312
NP_996803                                                              17    4312
NP_008835                                                              16    5631
NP_001075109                                                           16    5631
NP_060109                                                              16    5631
NP_055895                                                              16    5631
NP_787079                                                              16    5631
XP_006718807                                                           16    5631
NP_001231509                                                           16    7355
NP_003487                                                              16    7355
NP_056414                                                              16    7355
NP_001186846                                                           16    7355
NP_001186848                                                           16    7355
XP_006721876                                                           16    7355
XP_005257269                                                           16    7355
XP_006721875                                                           16    7355
XP_005257264                                                           16    7355
XP_005256370                                                           16    7355
XP_006715635                                                           16    7355
XP_005248785                                                           16    7355
XP_006715567                                                           16    7355
NP_001186847                                                           16    7355
NP_057293                                                              16    7355
NP_114155                                                              16    7355
NP_056469                                                              16    7355
NP_001001912                                                           15    9605
NP_055178                                                              15    9605
NP_003613                                                              15    9605
NP_001264984                                                           15    9605
NP_001185845                                                           15    9605
NP_803193                                                              15    9605
NP_001005512                                                           15    9605
NP_001185844                                                           15    9605
XP_005266395                                                           15    9605
XP_006719224                                                           15    9605
XP_006719222                                                           15    9605
XP_005253573                                                           15    9605
XP_005253572                                                           15    9605
XP_005253571                                                           15    9605
XP_005253568                                                           15    9605
XP_005253567                                                           15    9605
XP_005253566                                                           15    9605
XP_005253565                                                           15    9605
XP_005253564                                                           15    9605
XP_005253563                                                           15    9605
XP_005253562                                                           15    9605
XP_006718293                                                           15    9605
NP_001004698                                                           15    9605
NP_001005486                                                           15    9605
>NP_065681
          Length = 1072

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLHYMVVAT 9
           +LHYMVVAT
Sbjct: 480 ELHYMVVAT 488
>NP_066124
          Length = 1114

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLHYMVVAT 9
           +LHYMVVAT
Sbjct: 480 ELHYMVVAT 488
>XP_006717999
          Length = 1207

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLHYMVVAT 9
           +LHYMVVAT
Sbjct: 573 ELHYMVVAT 581
>NP_008864
          Length = 718

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LHYMVVAT 9
           +HYM VAT
Sbjct: 509 IHYMYVAT 516
>NP_982271
          Length = 1350

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LHYMVVAT 9
           LHY+V+ T
Sbjct: 114 LHYLVLVT 121
>NP_001153774
          Length = 1295

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>NP_109592
          Length = 1216

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LHYMVVA 8
           LH+MVVA
Sbjct: 666 LHWMVVA 672
>NP_003886
          Length = 1612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LHYMVVAT 9
           LHY+V+ T
Sbjct: 114 LHYLVLVT 121
>NP_002839
          Length = 1188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LHYMVVA 8
           LH+MVVA
Sbjct: 666 LHWMVVA 672
>NP_001153778
          Length = 1526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_005261137
          Length = 1264

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006724126
          Length = 1313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006724125
          Length = 1313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006724124
          Length = 1534

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_005261133
          Length = 1557

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006724123
          Length = 1560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006724122
          Length = 1568

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006724121
          Length = 1576

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LHYMVVAT 9
          LHY+V+ T
Sbjct: 75 LHYLVLVT 82
>XP_006722785
          Length = 363

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHYMV+
Sbjct: 174 LHYMVI 179
>NP_059976
          Length = 319

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHYMV+
Sbjct: 130 LHYMVI 135
>NP_001005190
          Length = 309

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHYMV+
Sbjct: 130 LHYMVI 135
>NP_001001957
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHYMV+
Sbjct: 130 LHYMVI 135
>NP_996803
          Length = 1137

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HYMVVAT 9
           HYMVV T
Sbjct: 777 HYMVVDT 783
>NP_008835
          Length = 4128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LHYMVV 7
            +HYMVV
Sbjct: 2182 IHYMVV 2187
>NP_001075109
          Length = 4097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    LHYMVV 7
            +HYMVV
Sbjct: 2182 IHYMVV 2187
>NP_060109
          Length = 2916

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLHYMVVA 8
           KLH+ +VA
Sbjct: 983 KLHFSIVA 990
>NP_055895
          Length = 1712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           KLHY+V
Sbjct: 395 KLHYLV 400
>NP_787079
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHYM++
Sbjct: 130 LHYMII 135
>XP_006718807
          Length = 1464

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           KLHY+V
Sbjct: 147 KLHYLV 152
>NP_001231509
          Length = 3859

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           KLHY+V
Sbjct: 911 KLHYVV 916
>NP_003487
          Length = 3830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           KLHY+V
Sbjct: 911 KLHYVV 916
>NP_056414
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           +LHYMV
Sbjct: 161 QLHYMV 166
>NP_001186846
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           +LHYMV
Sbjct: 189 QLHYMV 194
>NP_001186848
          Length = 566

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           +LHYMV
Sbjct: 161 QLHYMV 166
>XP_006721876
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           KLH+  VAT
Sbjct: 127 KLHFEQVAT 135
>XP_005257269
          Length = 176

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           KLH+  VAT
Sbjct: 127 KLHFEQVAT 135
>XP_006721875
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           KLH+  VAT
Sbjct: 157 KLHFEQVAT 165
>XP_005257264
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           KLH+  VAT
Sbjct: 157 KLHFEQVAT 165
>XP_005256370
          Length = 164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  KLHYMV 6
          K HYMV
Sbjct: 52 KFHYMV 57
>XP_006715635
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           K+H MV+ T
Sbjct: 271 KIHRMVILT 279
>XP_005248785
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KLHYMV 6
          +LHYMV
Sbjct: 80 QLHYMV 85
>XP_006715567
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KLHYMV 6
           +LHYMV
Sbjct: 189 QLHYMV 194
>NP_001186847
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KLHYMV 6
          +LHYMV
Sbjct: 80 QLHYMV 85
>NP_057293
          Length = 140

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  KLHYMV 6
          K HYMV
Sbjct: 27 KFHYMV 32
>NP_114155
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           K+H MV+ T
Sbjct: 344 KIHRMVILT 352
>NP_056469
          Length = 207

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KLHYMVVAT 9
           KLH+  VAT
Sbjct: 158 KLHFEQVAT 166
>NP_001001912
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HYMVVA 8
           H+MVVA
Sbjct: 243 HFMVVA 248
>NP_055178
          Length = 4579

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    LHYMV 6
            LHYMV
Sbjct: 3365 LHYMV 3369
>NP_003613
          Length = 1005

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 744 LHYMTV 749
>NP_001264984
          Length = 4432

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    LHYMV 6
            LHYMV
Sbjct: 3218 LHYMV 3222
>NP_001185845
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 719 LHYMTV 724
>NP_803193
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 750 LHYMTV 755
>NP_001005512
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHY+V+
Sbjct: 128 LHYLVI 133
>NP_001185844
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 597 LHYMTV 602
>XP_005266395
          Length = 4588

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2    LHYMV 6
            LHYMV
Sbjct: 3374 LHYMV 3378
>XP_006719224
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 730 LHYMTV 735
>XP_006719222
          Length = 883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 622 LHYMTV 627
>XP_005253573
          Length = 991

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 730 LHYMTV 735
>XP_005253572
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 733 LHYMTV 738
>XP_005253571
          Length = 1002

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 741 LHYMTV 746
>XP_005253568
          Length = 1014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 753 LHYMTV 758
>XP_005253567
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 764 LHYMTV 769
>XP_005253566
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 764 LHYMTV 769
>XP_005253565
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 765 LHYMTV 770
>XP_005253564
          Length = 1033

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 772 LHYMTV 777
>XP_005253563
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 775 LHYMTV 780
>XP_005253562
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 775 LHYMTV 780
>XP_006718293
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   LHYMVV 7
           LHY+V+
Sbjct: 128 LHYLVI 133
>NP_001004698
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 130 LHYMAV 135
>NP_001005486
          Length = 348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   LHYMVV 7
           LHYM V
Sbjct: 154 LHYMTV 159
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.333    0.133    0.386 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 479,713
Number of extensions: 420
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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