Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002515                                                              21     229
NP_997190                                                              20     390
XP_005247947                                                           20     390
XP_006713884                                                           20     390
NP_055168                                                              20     390
NP_789765                                                              19     665
NP_001123914                                                           19     665
NP_005334                                                              19     665
NP_004976                                                              19     665
NP_203524                                                              19     665
XP_006725199                                                           19     665
XP_006719132                                                           19     665
XP_006718280                                                           19     665
NP_660208                                                              18    1135
XP_006714180                                                           18    1135
XP_005262841                                                           18    1135
XP_005262840                                                           18    1135
NP_757344                                                              17    2528
NP_115670                                                              17    2528
NP_061882                                                              17    2528
XP_005256876                                                           17    2528
XP_006721651                                                           17    2528
XP_005256874                                                           17    2528
NP_757343                                                              17    2528
NP_775899                                                              17    3301
NP_937762                                                              17    4312
NP_001121189                                                           17    4312
XP_005276813                                                           17    4312
XP_005248455                                                           17    4312
NP_001790                                                              17    4312
NP_055830                                                              16    5631
NP_001277270                                                           16    5631
NP_001277272                                                           16    5631
NP_001277271                                                           16    5631
NP_001182465                                                           16    5631
NP_057494                                                              16    5631
NP_849164                                                              16    5631
NP_055478                                                              16    5631
NP_919274                                                              16    5631
XP_005259578                                                           16    5631
XP_006720497                                                           16    5631
XP_005271413                                                           16    5631
XP_005271412                                                           16    5631
XP_005271411                                                           16    5631
NP_000013                                                              16    7355
NP_005198                                                              16    7355
NP_001140168                                                           16    7355
NP_001140167                                                           16    7355
NP_055876                                                              16    7355
NP_001012747                                                           16    7355
NP_001140166                                                           16    7355
XP_005260293                                                           16    7355
XP_006723742                                                           16    7355
XP_006716804                                                           16    7355
NP_001035194                                                           16    7355
NP_060454                                                              15    9605
NP_006571                                                              15    9605
NP_001012651                                                           15    9605
NP_005361                                                              15    9605
NP_001244937                                                           15    9605
NP_057715                                                              15    9605
NP_037461                                                              15    9605
XP_006724130                                                           15    9605
XP_006724129                                                           15    9605
XP_005267654                                                           15    9605
XP_005250538                                                           15    9605
XP_005250537                                                           15    9605
XP_005250536                                                           15    9605
XP_006716103                                                           15    9605
XP_006716102                                                           15    9605
XP_006716101                                                           15    9605
XP_006716100                                                           15    9605
XP_006716099                                                           15    9605
XP_006716098                                                           15    9605
XP_006713542                                                           15    9605
>NP_002515
          Length = 189

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KLAKSYGIP 9
           +LAKSYGIP
Sbjct: 132 ELAKSYGIP 140
>NP_997190
          Length = 572

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           KL KSYG+P
Sbjct: 400 KLCKSYGLP 408
>XP_005247947
          Length = 437

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           KL KSYG+P
Sbjct: 400 KLCKSYGLP 408
>XP_006713884
          Length = 481

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           KL KSYG+P
Sbjct: 400 KLCKSYGLP 408
>NP_055168
          Length = 256

 Score = 20.0 bits (40), Expect =   390
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           KLAK YG+P
Sbjct: 194 KLAKEYGLP 202
>NP_789765
          Length = 170

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>NP_001123914
          Length = 189

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>NP_005334
          Length = 189

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>NP_004976
          Length = 188

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>NP_203524
          Length = 189

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>XP_006725199
          Length = 170

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>XP_006719132
          Length = 189

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>XP_006718280
          Length = 170

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 2   LAKSYGIP 9
           LA+SYGIP
Sbjct: 133 LARSYGIP 140
>NP_660208
          Length = 893

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           +L KSYGIP
Sbjct: 377 ELFKSYGIP 385
>XP_006714180
          Length = 799

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           +L KSYGIP
Sbjct: 377 ELFKSYGIP 385
>XP_005262841
          Length = 835

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           +L KSYGIP
Sbjct: 377 ELFKSYGIP 385
>XP_005262840
          Length = 892

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KLAKSYGIP 9
           +L KSYGIP
Sbjct: 376 ELFKSYGIP 384
>NP_757344
          Length = 520

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KLAKSYGIP 9
           KL K YG P
Sbjct: 163 KLLKQYGFP 171
>NP_115670
          Length = 505

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KLAKSYGIP 9
           KL K YG P
Sbjct: 163 KLLKQYGFP 171
>NP_061882
          Length = 274

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  KLAKSYGI 8
          KLAK+YG+
Sbjct: 63 KLAKNYGM 70
>XP_005256876
          Length = 432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  KLAKSYGIP 9
          KL K YG P
Sbjct: 52 KLLKQYGFP 60
>XP_006721651
          Length = 543

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KLAKSYGIP 9
           KL K YG P
Sbjct: 163 KLLKQYGFP 171
>XP_005256874
          Length = 543

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KLAKSYGIP 9
           KL K YG P
Sbjct: 163 KLLKQYGFP 171
>NP_757343
          Length = 505

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KLAKSYGIP 9
           KL K YG P
Sbjct: 163 KLLKQYGFP 171
>NP_775899
          Length = 4462

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LAKSYGIP 9
            L K YGIP
Sbjct: 2827 LKKGYGIP 2834
>NP_937762
          Length = 3333

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    AKSYGIP 9
            AKS+G+P
Sbjct: 1540 AKSFGLP 1546
>NP_001121189
          Length = 3277

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    AKSYGIP 9
            AKS+G+P
Sbjct: 1540 AKSFGLP 1546
>XP_005276813
          Length = 289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           LAKS+G P
Sbjct: 101 LAKSFGSP 108
>XP_005248455
          Length = 289

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           LAKS+G P
Sbjct: 101 LAKSFGSP 108
>NP_001790
          Length = 346

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           LAKS+G P
Sbjct: 158 LAKSFGSP 165
>NP_055830
          Length = 1096

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           + K YGIP
Sbjct: 250 ILKKYGIP 257
>NP_001277270
          Length = 394

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LAKSYGI 8
          LAKS+GI
Sbjct: 75 LAKSFGI 81
>NP_001277272
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LAKSYGI 8
          LAKS+GI
Sbjct: 64 LAKSFGI 70
>NP_001277271
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LAKSYGI 8
          LAKS+GI
Sbjct: 64 LAKSFGI 70
>NP_001182465
          Length = 171

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           L++SYG P
Sbjct: 149 LSRSYGTP 156
>NP_057494
          Length = 219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           L++SYG P
Sbjct: 149 LSRSYGTP 156
>NP_849164
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LAKSYGI 8
          LAKS+GI
Sbjct: 64 LAKSFGI 70
>NP_055478
          Length = 1064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           + K YGIP
Sbjct: 249 MLKKYGIP 256
>NP_919274
          Length = 509

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KLAKSYGI 8
           KLA +YGI
Sbjct: 427 KLAHAYGI 434
>XP_005259578
          Length = 1130

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           + K YGIP
Sbjct: 250 ILKKYGIP 257
>XP_006720497
          Length = 383

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  LAKSYGI 8
          LAKS+GI
Sbjct: 64 LAKSFGI 70
>XP_005271413
          Length = 973

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           + K YGIP
Sbjct: 158 MLKKYGIP 165
>XP_005271412
          Length = 1064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           + K YGIP
Sbjct: 249 MLKKYGIP 256
>XP_005271411
          Length = 1064

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           + K YGIP
Sbjct: 249 MLKKYGIP 256
>NP_000013
          Length = 363

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           L K+YG+P
Sbjct: 347 LYKAYGMP 354
>NP_005198
          Length = 303

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AKSYGIP 9
           + SYGIP
Sbjct: 195 SNSYGIP 201
>NP_001140168
          Length = 835

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   KSYGIP 9
           K YGIP
Sbjct: 275 KKYGIP 280
>NP_001140167
          Length = 813

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   KSYGIP 9
           K YGIP
Sbjct: 253 KKYGIP 258
>NP_055876
          Length = 1056

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   KSYGIP 9
           K YGIP
Sbjct: 253 KKYGIP 258
>NP_001012747
          Length = 204

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KLAKSYGIP 9
           +LAK  G+P
Sbjct: 133 ELAKEIGVP 141
>NP_001140166
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   KSYGIP 9
           K YGIP
Sbjct: 253 KKYGIP 258
>XP_005260293
          Length = 339

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           L K+YG+P
Sbjct: 323 LYKAYGMP 330
>XP_006723742
          Length = 354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LAKSYGIP 9
           L K+YG+P
Sbjct: 338 LYKAYGMP 345
>XP_006716804
          Length = 1089

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   KSYGIP 9
           K YGIP
Sbjct: 253 KKYGIP 258
>NP_001035194
          Length = 4493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    KLAKSYG 7
            K+AK YG
Sbjct: 4319 KMAKEYG 4325
>NP_060454
          Length = 648

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 323 AKQYGYP 329
>NP_006571
          Length = 305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           +AKSY  P
Sbjct: 284 MAKSYSAP 291
>NP_001012651
          Length = 131

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   KSYGIP 9
           KSYG P
Sbjct: 107 KSYGAP 112
>NP_005361
          Length = 207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KLAKSYGI 8
           KLA  YGI
Sbjct: 138 KLALDYGI 145
>NP_001244937
          Length = 524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 324 AKQYGYP 330
>NP_057715
          Length = 917

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   SYGIP 9
           SYGIP
Sbjct: 350 SYGIP 354
>NP_037461
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   SYGIP 9
           SYGIP
Sbjct: 350 SYGIP 354
>XP_006724130
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   SYGIP 9
           SYGIP
Sbjct: 350 SYGIP 354
>XP_006724129
          Length = 882

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   SYGIP 9
           SYGIP
Sbjct: 350 SYGIP 354
>XP_005267654
          Length = 212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KLAKSYGI 8
           +LAK YG+
Sbjct: 138 QLAKEYGM 145
>XP_005250538
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_005250537
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_005250536
          Length = 525

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_006716103
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_006716102
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_006716101
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 324 AKQYGYP 330
>XP_006716100
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 324 AKQYGYP 330
>XP_006716099
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_006716098
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 3   AKSYGIP 9
           AK YG P
Sbjct: 325 AKQYGYP 331
>XP_006713542
          Length = 250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   LAKSYGIP 9
           +AKSY  P
Sbjct: 229 MAKSYSAP 236
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.137    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 492,070
Number of extensions: 748
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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