Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001001557                                                           19     665
NP_689707                                                              17    2528
NP_001137159                                                           17    2528
NP_061881                                                              17    3301
NP_002154                                                              17    4312
NP_006075                                                              17    4312
NP_001136028                                                           17    4312
NP_036616                                                              17    4312
NP_002451                                                              17    4312
NP_001182215                                                           17    4312
NP_001136029                                                           17    4312
NP_036617                                                              17    4312
XP_005260860                                                           17    4312
XP_005260859                                                           17    4312
XP_005260858                                                           17    4312
XP_005260857                                                           17    4312
XP_006723671                                                           17    4312
XP_006723670                                                           17    4312
XP_005260854                                                           17    4312
XP_006723669                                                           17    4312
XP_006721250                                                           17    4312
XP_006715153                                                           17    4312
NP_071927                                                              17    4312
XP_003846671                                                           16    5631
NP_079350                                                              16    7355
NP_057427                                                              16    7355
NP_114113                                                              16    7355
NP_277037                                                              16    7355
NP_065685                                                              16    7355
NP_438170                                                              16    7355
NP_077015                                                              16    7355
XP_006719018                                                           16    7355
XP_006719016                                                           16    7355
XP_006719015                                                           16    7355
XP_006715212                                                           16    7355
XP_006715211                                                           16    7355
XP_006715210                                                           16    7355
XP_006715209                                                           16    7355
XP_006715208                                                           16    7355
XP_006715207                                                           16    7355
XP_006715206                                                           16    7355
XP_005249280                                                           16    7355
XP_006714380                                                           16    7355
XP_006714379                                                           16    7355
XP_006714378                                                           16    7355
XP_006714377                                                           16    7355
NP_001244899                                                           16    7355
NP_001124334                                                           16    7355
NP_006470                                                              16    7355
NP_006556                                                              15    9605
NP_009122                                                              15    9605
NP_599152                                                              15    9605
NP_443166                                                              15    9605
NP_001269864                                                           15    9605
NP_001269862                                                           15    9605
NP_116208                                                              15    9605
NP_079527                                                              15    9605
NP_065827                                                              15    9605
NP_065789                                                              15    9605
XP_005258376                                                           15    9605
XP_005258375                                                           15    9605
XP_005258374                                                           15    9605
XP_006722574                                                           15    9605
XP_006722573                                                           15    9605
XP_005258372                                                           15    9605
XP_005255832                                                           15    9605
XP_006716724                                                           15    9605
XP_006711207                                                           15    9605
>NP_001001557
          Length = 455

 Score = 19.2 bits (38), Expect =   665
 Identities = 7/8 (87%), Positives = 8/8 (100%)

Query: 1   KKSKLRCS 8
           KKS+LRCS
Sbjct: 348 KKSRLRCS 355
>NP_689707
          Length = 706

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KSKLRCS 8
           K+KLRCS
Sbjct: 243 KTKLRCS 249
>NP_001137159
          Length = 681

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KSKLRCS 8
           K+KLRCS
Sbjct: 218 KTKLRCS 224
>NP_061881
          Length = 463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKSKLRCSL 9
           KKS+LR SL
Sbjct: 127 KKSRLRMSL 135
>NP_002154
          Length = 426

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSKLRCSL 9
          K++LRC+L
Sbjct: 79 KTRLRCAL 86
>NP_006075
          Length = 393

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSKLRCSL 9
          K++LRC+L
Sbjct: 81 KTRLRCAL 88
>NP_001136028
          Length = 725

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SKLRCSL 9
           SKLRC L
Sbjct: 657 SKLRCQL 663
>NP_036616
          Length = 724

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SKLRCSL 9
           SKLRC L
Sbjct: 656 SKLRCQL 662
>NP_002451
          Length = 451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KSKLRCSL 9
           K++LRC+L
Sbjct: 94  KTRLRCAL 101
>NP_001182215
          Length = 450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KSKLRCSL 9
           K++LRC+L
Sbjct: 94  KTRLRCAL 101
>NP_001136029
          Length = 638

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SKLRCSL 9
           SKLRC L
Sbjct: 570 SKLRCQL 576
>NP_036617
          Length = 709

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SKLRCSL 9
           SKLRC L
Sbjct: 641 SKLRCQL 647
>XP_005260860
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_005260859
          Length = 545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_005260858
          Length = 643

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_005260857
          Length = 677

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_006723671
          Length = 684

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_006723670
          Length = 711

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_005260854
          Length = 711

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_006723669
          Length = 718

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_006721250
          Length = 436

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  KSKLRCSL 9
          K++LRC+L
Sbjct: 89 KTRLRCAL 96
>XP_006715153
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KSKLRCSL 9
           K++LRC+L
Sbjct: 94  KTRLRCAL 101
>NP_071927
          Length = 711

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           KKS  +CS+
Sbjct: 313 KKSNFKCSI 321
>XP_003846671
          Length = 607

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SKLRCSL 9
           SKLRC L
Sbjct: 450 SKLRCPL 456
>NP_079350
          Length = 4012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KKSKLRCS 8
            + SK+RCS
Sbjct: 3075 RTSKVRCS 3082
>NP_057427
          Length = 3114

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KKSKLRCSL 9
            K SKL C L
Sbjct: 1049 KNSKLECLL 1057
>NP_114113
          Length = 913

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KKSKLRCS 8
           KKSK  CS
Sbjct: 204 KKSKADCS 211
>NP_277037
          Length = 1200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>NP_065685
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SKLRCSL 9
           ++LRCSL
Sbjct: 223 ARLRCSL 229
>NP_438170
          Length = 434

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           +KSK+ C L
Sbjct: 97  QKSKMACQL 105
>NP_077015
          Length = 1004

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           +KSK+ C L
Sbjct: 334 QKSKMACQL 342
>XP_006719018
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           KKSK +C+
Sbjct: 113 KKSKSKCN 120
>XP_006719016
          Length = 265

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           KKSK +C+
Sbjct: 161 KKSKSKCN 168
>XP_006719015
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           KKSK +C+
Sbjct: 231 KKSKSKCN 238
>XP_006715212
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  KSKLRCSL 9
          K+KL CS+
Sbjct: 30 KNKLTCSI 37
>XP_006715211
          Length = 1117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_006715210
          Length = 1129

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_006715209
          Length = 1131

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_006715208
          Length = 1200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_006715207
          Length = 1212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_006715206
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_005249280
          Length = 1220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KSKLRCSL 9
           K+KL CS+
Sbjct: 509 KNKLTCSI 516
>XP_006714380
          Length = 3897

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KKSKLRCS 8
            + SK+RCS
Sbjct: 2960 RTSKVRCS 2967
>XP_006714379
          Length = 3936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KKSKLRCS 8
            + SK+RCS
Sbjct: 2999 RTSKVRCS 3006
>XP_006714378
          Length = 3965

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KKSKLRCS 8
            + SK+RCS
Sbjct: 3028 RTSKVRCS 3035
>XP_006714377
          Length = 4010

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    KKSKLRCS 8
            + SK+RCS
Sbjct: 3073 RTSKVRCS 3080
>NP_001244899
          Length = 740

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           +KSK+ C L
Sbjct: 334 QKSKMACQL 342
>NP_001124334
          Length = 352

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           KKSK +C+
Sbjct: 248 KKSKSKCN 255
>NP_006470
          Length = 335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           KKSK +C+
Sbjct: 231 KKSKSKCN 238
>NP_006556
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KKSKLR 6
           KKSKLR
Sbjct: 208 KKSKLR 213
>NP_009122
          Length = 379

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KSKLRCS 8
           KSK +CS
Sbjct: 291 KSKCKCS 297
>NP_599152
          Length = 887

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           +KSKL C +
Sbjct: 457 RKSKLDCCI 465
>NP_443166
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           +KSKL C +
Sbjct: 457 RKSKLDCCI 465
>NP_001269864
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KKSKLRCS 8
           K  KL+CS
Sbjct: 228 KAQKLKCS 235
>NP_001269862
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KKSKLRCS 8
           K  KL+CS
Sbjct: 318 KAQKLKCS 325
>NP_116208
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KKSKLRCS 8
           K  KL+CS
Sbjct: 311 KAQKLKCS 318
>NP_079527
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KKSKLR 6
           KKSKLR
Sbjct: 855 KKSKLR 860
>NP_065827
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           +KS L+CS
Sbjct: 196 RKSTLQCS 203
>NP_065789
          Length = 1771

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KKSKLRCSL 9
            KKS   CSL
Sbjct: 1650 KKSPSECSL 1658
>XP_005258376
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KKSKLRCS 8
          +KS L+CS
Sbjct: 88 RKSTLQCS 95
>XP_005258375
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           +KS L+CS
Sbjct: 151 RKSTLQCS 158
>XP_005258374
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           +KS L+CS
Sbjct: 192 RKSTLQCS 199
>XP_006722574
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           +KS L+CS
Sbjct: 196 RKSTLQCS 203
>XP_006722573
          Length = 609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           +KS L+CS
Sbjct: 192 RKSTLQCS 199
>XP_005258372
          Length = 613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKSKLRCS 8
           +KS L+CS
Sbjct: 196 RKSTLQCS 203
>XP_005255832
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KKSKLR 6
           KKSKLR
Sbjct: 208 KKSKLR 213
>XP_006716724
          Length = 970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KKSKLR 6
           KKSKLR
Sbjct: 711 KKSKLR 716
>XP_006711207
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKSKLRCSL 9
           +KSKL C +
Sbjct: 457 RKSKLDCCI 465
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.320    0.126    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 710,650
Number of extensions: 1066
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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