Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_955452                                                              17    4312
XP_006713543                                                           17    4312
NP_001092882                                                           16    5631
NP_006757                                                              16    5631
NP_001092883                                                           16    5631
XP_006716734                                                           16    5631
XP_006716732                                                           16    5631
XP_006716731                                                           16    5631
XP_006716730                                                           16    5631
XP_005273706                                                           16    5631
NP_652760                                                              16    7355
NP_001263191                                                           16    7355
NP_001269851                                                           16    7355
NP_001269852                                                           16    7355
NP_001263189                                                           16    7355
NP_602299                                                              16    7355
NP_001263190                                                           16    7355
NP_652759                                                              16    7355
NP_570613                                                              16    7355
NP_001136017                                                           16    7355
NP_065928                                                              16    7355
NP_065154                                                              16    7355
XP_005256527                                                           16    7355
XP_005267943                                                           16    7355
XP_005267942                                                           16    7355
XP_006717293                                                           16    7355
XP_006717292                                                           16    7355
XP_006717291                                                           16    7355
XP_006717290                                                           16    7355
XP_006717289                                                           16    7355
XP_006717288                                                           16    7355
XP_006717287                                                           16    7355
XP_006717285                                                           16    7355
XP_006717284                                                           16    7355
XP_006717283                                                           16    7355
XP_006717282                                                           16    7355
NP_001360                                                              15    9605
NP_001035351                                                           15    9605
NP_001035350                                                           15    9605
NP_001182345                                                           15    9605
NP_004725                                                              15    9605
NP_001182344                                                           15    9605
NP_001269828                                                           15    9605
NP_001269829                                                           15    9605
NP_001269830                                                           15    9605
NP_001093867                                                           15    9605
NP_008954                                                              15    9605
NP_004724                                                              15    9605
NP_001177921                                                           15    9605
NP_741996                                                              15    9605
NP_001264307                                                           15    9605
XP_006719956                                                           15    9605
XP_005266649                                                           15    9605
XP_005248319                                                           15    9605
XP_005262843                                                           15    9605
XP_005262842                                                           15    9605
XP_006713885                                                           15    9605
XP_006712269                                                           15    9605
XP_006712268                                                           15    9605
XP_005246303                                                           15    9605
>NP_955452
          Length = 2590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KKNEISI 7
            KKNE+S+
Sbjct: 1431 KKNEVSV 1437
>XP_006713543
          Length = 2591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KKNEISI 7
            KKNE+S+
Sbjct: 1432 KKNEVSV 1438
>NP_001092882
          Length = 2004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           +KN IS+F
Sbjct: 572 RKNNISVF 579
>NP_006757
          Length = 2004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           +KN IS+F
Sbjct: 572 RKNNISVF 579
>NP_001092883
          Length = 2004

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           +KN IS+F
Sbjct: 572 RKNNISVF 579
>XP_006716734
          Length = 264

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KKNEISIF 8
          KKNE+S F
Sbjct: 18 KKNELSNF 25
>XP_006716732
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KKNEISIF 8
          KKNE+S F
Sbjct: 18 KKNELSNF 25
>XP_006716731
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KKNEISIF 8
          KKNE+S F
Sbjct: 18 KKNELSNF 25
>XP_006716730
          Length = 300

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KKNEISIF 8
          KKNE+S F
Sbjct: 18 KKNELSNF 25
>XP_005273706
          Length = 1997

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           +KN IS+F
Sbjct: 565 RKNNISVF 572
>NP_652760
          Length = 311

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 145 KNKLGIFR 152
>NP_001263191
          Length = 168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 KNEISIFR 9
         KN++ IFR
Sbjct: 2 KNKLGIFR 9
>NP_001269851
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>NP_001269852
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 922 KNKLGIFR 929
>NP_001263189
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>NP_602299
          Length = 168

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2 KNEISIFR 9
         KN++ IFR
Sbjct: 2 KNKLGIFR 9
>NP_001263190
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 425 KNKLGIFR 432
>NP_652759
          Length = 1198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    KNEISIFR 9
            KN++ IFR
Sbjct: 1032 KNKLGIFR 1039
>NP_570613
          Length = 917

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 751 KNKLGIFR 758
>NP_001136017
          Length = 455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KKNEISIFR 9
           KKN  S FR
Sbjct: 402 KKNTCSFFR 410
>NP_065928
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KKNEISI 7
            KKN++SI
Sbjct: 1683 KKNQVSI 1689
>NP_065154
          Length = 523

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KKNEISIFR 9
           KKN  S FR
Sbjct: 470 KKNTCSFFR 478
>XP_005256527
          Length = 4427

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KKNEISI 7
            KKN++SI
Sbjct: 1683 KKNQVSI 1689
>XP_005267943
          Length = 457

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KKNEISIFR 9
           KKN  S FR
Sbjct: 404 KKNTCSFFR 412
>XP_005267942
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KKNEISIFR 9
           KKN  S FR
Sbjct: 431 KKNTCSFFR 439
>XP_006717293
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>XP_006717292
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>XP_006717291
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>XP_006717290
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>XP_006717289
          Length = 519

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 353 KNKLGIFR 360
>XP_006717288
          Length = 521

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 355 KNKLGIFR 362
>XP_006717287
          Length = 537

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 371 KNKLGIFR 378
>XP_006717285
          Length = 824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 658 KNKLGIFR 665
>XP_006717284
          Length = 961

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 795 KNKLGIFR 802
>XP_006717283
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 920 KNKLGIFR 927
>XP_006717282
          Length = 1094

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           KN++ IFR
Sbjct: 928 KNKLGIFR 935
>NP_001360
          Length = 4624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKNEISIFR 9
            K+N + IFR
Sbjct: 1003 KQNSLPIFR 1011
>NP_001035351
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 455 ENEVSILR 462
>NP_001035350
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 438 ENEVSILR 445
>NP_001182345
          Length = 433

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 127 QNEVSILR 134
>NP_004725
          Length = 729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 434 QNEVSILR 441
>NP_001182344
          Length = 422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 127 QNEVSILR 134
>NP_001269828
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 571 KPNDVSVF 578
>NP_001269829
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 553 KPNDVSVF 560
>NP_001269830
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 504 KPNDVSVF 511
>NP_001093867
          Length = 867

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 580 KPNDVSVF 587
>NP_008954
          Length = 1011

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 724 KPNDVSVF 731
>NP_004724
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KKNEISIFR 9
           K+NE+S+ +
Sbjct: 280 KENEVSVVK 288
>NP_001177921
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KKNEISIFR 9
           K+NE+S+ +
Sbjct: 280 KENEVSVVK 288
>NP_741996
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KKNEISIFR 9
            K NEIS+ +
Sbjct: 1226 KNNEISVIQ 1234
>NP_001264307
          Length = 358

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NEISIFR 9
           +E+SIFR
Sbjct: 209 HEVSIFR 215
>XP_006719956
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 434 QNEVSILR 441
>XP_005266649
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 434 QNEVSILR 441
>XP_005248319
          Length = 4609

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KKNEISIFR 9
           K+N + IFR
Sbjct: 988 KQNSLPIFR 996
>XP_005262843
          Length = 765

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 437 ENEVSILR 444
>XP_005262842
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KNEISIFR 9
           +NE+SI R
Sbjct: 454 ENEVSILR 461
>XP_006713885
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   KKNEISIFR 9
           K+NE+S+ +
Sbjct: 280 KENEVSVVK 288
>XP_006712269
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 551 KPNDVSVF 558
>XP_006712268
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 553 KPNDVSVF 560
>XP_005246303
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KKNEISIF 8
           K N++S+F
Sbjct: 706 KPNDVSVF 713
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.138    0.351 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 418,092
Number of extensions: 625
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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