Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001185761                                                           19     869
NP_055459                                                              19     869
XP_006726410                                                           19     869
XP_006711719                                                           19     869
XP_006711716                                                           19     869
XP_005273038                                                           19     869
XP_006711164                                                           19     869
NP_002356                                                              17    2528
NP_001185763                                                           17    2528
XP_006726436                                                           17    2528
XP_005274567                                                           17    2528
XP_006711784                                                           17    2528
XP_006711718                                                           17    2528
XP_006711717                                                           17    2528
XP_006711715                                                           17    2528
XP_006711714                                                           17    2528
XP_006711713                                                           17    2528
XP_006711712                                                           17    2528
XP_006711711                                                           17    2528
XP_006711710                                                           17    2528
XP_006711709                                                           17    2528
XP_005277503                                                           17    2528
XP_006711708                                                           17    2528
XP_005277500                                                           17    2528
XP_006711707                                                           17    2528
XP_005277499                                                           17    2528
XP_006711706                                                           17    2528
XP_006711705                                                           17    2528
XP_005276114                                                           17    2528
XP_006710122                                                           17    2528
NP_001138501                                                           17    4312
XP_006722388                                                           17    4312
NP_001157853                                                           16    5631
NP_055208                                                              16    5631
NP_001157857                                                           16    5631
NP_001157856                                                           16    5631
NP_001157852                                                           16    5631
NP_001157854                                                           16    5631
NP_001157855                                                           16    5631
NP_694590                                                              15    9605
NP_005493                                                              15    9605
NP_002805                                                              15    9605
XP_006717060                                                           15    9605
XP_005251847                                                           15    9605
XP_005251846                                                           15    9605
XP_005251837                                                           15    9605
XP_005251835                                                           15    9605
XP_006717058                                                           15    9605
XP_005251833                                                           15    9605
XP_005251831                                                           15    9605
XP_005251830                                                           15    9605
>NP_001185761
          Length = 2240

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2220 KKARTNLEV 2228
>NP_055459
          Length = 2346

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2326 KKARTNLEV 2334
>XP_006726410
          Length = 2087

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2067 KKARTNLEV 2075
>XP_006711719
          Length = 2302

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2282 KKARTNLEV 2290
>XP_006711716
          Length = 2411

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2391 KKARTNLEV 2399
>XP_005273038
          Length = 2509

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2489 KKARTNLEV 2497
>XP_006711164
          Length = 2087

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    KKASTNLEV 9
            KKA TNLEV
Sbjct: 2067 KKARTNLEV 2075
>NP_002356
          Length = 346

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKASTNLEV 9
           KKAS N+EV
Sbjct: 154 KKASFNMEV 162
>NP_001185763
          Length = 2362

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2326 KKARTNLE 2333
>XP_006726436
          Length = 178

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KKASTNLE 8
           KKA TNLE
Sbjct: 104 KKARTNLE 111
>XP_005274567
          Length = 346

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KKASTNLEV 9
           KKAS N+EV
Sbjct: 154 KKASFNMEV 162
>XP_006711784
          Length = 178

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KKASTNLE 8
           KKA TNLE
Sbjct: 104 KKARTNLE 111
>XP_006711718
          Length = 1436

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 1333 KKARTNLE 1340
>XP_006711717
          Length = 2385

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2282 KKARTNLE 2289
>XP_006711715
          Length = 2428

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2325 KKARTNLE 2332
>XP_006711714
          Length = 2429

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2326 KKARTNLE 2333
>XP_006711713
          Length = 2432

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2329 KKARTNLE 2336
>XP_006711712
          Length = 2473

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2370 KKARTNLE 2377
>XP_006711711
          Length = 2482

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2379 KKARTNLE 2386
>XP_006711710
          Length = 2494

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2391 KKARTNLE 2398
>XP_006711709
          Length = 2495

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2392 KKARTNLE 2399
>XP_005277503
          Length = 2498

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2489 KKARTNLE 2496
>XP_006711708
          Length = 2512

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2409 KKARTNLE 2416
>XP_005277500
          Length = 2525

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2489 KKARTNLE 2496
>XP_006711707
          Length = 2553

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2450 KKARTNLE 2457
>XP_005277499
          Length = 2561

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2489 KKARTNLE 2496
>XP_006711706
          Length = 2591

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2488 KKARTNLE 2495
>XP_006711705
          Length = 2592

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1    KKASTNLE 8
            KKA TNLE
Sbjct: 2489 KKARTNLE 2496
>XP_005276114
          Length = 134

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1  KKASTNLE 8
          KKA TNLE
Sbjct: 74 KKARTNLE 81
>XP_006710122
          Length = 126

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   KKASTNLE 8
           KKA TNLE
Sbjct: 104 KKARTNLE 111
>NP_001138501
          Length = 1392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KASTNLEV 9
           KASTN++V
Sbjct: 404 KASTNVDV 411
>XP_006722388
          Length = 1511

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   KASTNLEV 9
           KASTN++V
Sbjct: 404 KASTNVDV 411
>NP_001157853
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 344 KASTNLQ 350
>NP_055208
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 344 KASTNLQ 350
>NP_001157857
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 338 KASTNLQ 344
>NP_001157856
          Length = 479

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 344 KASTNLQ 350
>NP_001157852
          Length = 570

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 376 KASTNLQ 382
>NP_001157854
          Length = 504

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 272 KASTNLQ 278
>NP_001157855
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTNL+
Sbjct: 204 KASTNLQ 210
>NP_694590
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KKASTNLEV 9
           KKA+TN ++
Sbjct: 157 KKANTNTDL 165
>NP_005493
          Length = 2261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKASTNLEV 9
           KK+S+NL++
Sbjct: 136 KKSSSNLKL 144
>NP_002805
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KASTNLE 8
           KASTN++
Sbjct: 162 KASTNIQ 168
>XP_006717060
          Length = 343

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KKASTNLEV 9
           KKA+TN ++
Sbjct: 158 KKANTNTDL 166
>XP_005251847
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KKASTNLEV 9
           KKA+TN ++
Sbjct: 183 KKANTNTDL 191
>XP_005251846
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KKASTNLEV 9
           KKA+TN ++
Sbjct: 184 KKANTNTDL 192
>XP_005251837
          Length = 1659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKASTNLEV 9
           KK+S+NL++
Sbjct: 136 KKSSSNLKL 144
>XP_005251835
          Length = 2074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKASTNLEV 9
           KK+S+NL++
Sbjct: 136 KKSSSNLKL 144
>XP_006717058
          Length = 2100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKASTNLEV 9
           KK+S+NL++
Sbjct: 136 KKSSSNLKL 144
>XP_005251833
          Length = 2203

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1  KKASTNLEV 9
          KK+S+NL++
Sbjct: 76 KKSSSNLKL 84
>XP_005251831
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKASTNLEV 9
           KK+S+NL++
Sbjct: 136 KKSSSNLKL 144
>XP_005251830
          Length = 2263

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KKASTNLEV 9
           KK+S+NL++
Sbjct: 136 KKSSSNLKL 144
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.290    0.106    0.238 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 269,961
Number of extensions: 364
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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