Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_002430                                                              19     665
NP_001008723                                                           18    1935
NP_001138508                                                           17    4312
NP_031383                                                              17    4312
NP_000069                                                              16    7355
NP_001273014                                                           16    7355
NP_004504                                                              16    7355
NP_001165599                                                           16    7355
NP_757366                                                              16    7355
NP_733751                                                              16    7355
NP_001128128                                                           16    7355
NP_997287                                                              16    7355
XP_006721187                                                           16    7355
XP_005254403                                                           16    7355
XP_005254402                                                           16    7355
XP_005254401                                                           16    7355
XP_005254400                                                           16    7355
XP_005254399                                                           16    7355
XP_006716142                                                           16    7355
XP_005250088                                                           16    7355
XP_006716141                                                           16    7355
XP_005250085                                                           16    7355
XP_006716140                                                           16    7355
XP_005250084                                                           16    7355
XP_005250083                                                           16    7355
XP_005250082                                                           16    7355
NP_001035820                                                           15    9605
NP_001035822                                                           15    9605
NP_001035816                                                           15    9605
NP_001035823                                                           15    9605
NP_001035818                                                           15    9605
NP_056420                                                              15    9605
NP_001035817                                                           15    9605
NP_001278017                                                           15    9605
NP_114157                                                              15    9605
NP_001258579                                                           15    9605
NP_071906                                                              15    9605
NP_001276018                                                           15    9605
NP_079048                                                              15    9605
NP_001276019                                                           15    9605
NP_001276017                                                           15    9605
NP_001276020                                                           15    9605
NP_001127905                                                           15    9605
NP_055592                                                              15    9605
NP_001127904                                                           15    9605
XP_006726580                                                           15    9605
XP_006726579                                                           15    9605
XP_006723474                                                           15    9605
XP_005259362                                                           15    9605
XP_005270372                                                           15    9605
XP_006717817                                                           15    9605
XP_005277709                                                           15    9605
XP_005265449                                                           15    9605
XP_005273417                                                           15    9605
XP_005271279                                                           15    9605
XP_005271277                                                           15    9605
XP_005271276                                                           15    9605
XP_005271275                                                           15    9605
XP_005271273                                                           15    9605
>NP_002430
          Length = 1137

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KILNEQTAK 9
           KILNEQ AK
Sbjct: 687 KILNEQAAK 695
>NP_001008723
          Length = 872

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   KILNEQTAK 9
           KILNE+ AK
Sbjct: 264 KILNERAAK 272
>NP_001138508
          Length = 737

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KILNEQTAK 9
           KILN Q++K
Sbjct: 145 KILNSQSSK 153
>NP_031383
          Length = 738

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KILNEQTAK 9
           KILN Q++K
Sbjct: 145 KILNSQSSK 153
>NP_000069
          Length = 493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ILNEQTAK 9
          +LN +TAK
Sbjct: 39 VLNHETAK 46
>NP_001273014
          Length = 433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ILNEQTAK 9
          +LN +TAK
Sbjct: 39 VLNHETAK 46
>NP_004504
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KILNEQTAK 9
           K+L+E+T+K
Sbjct: 277 KLLDEKTSK 285
>NP_001165599
          Length = 1331

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KILNEQTAK 9
           K+L+E+T+K
Sbjct: 978 KLLDEKTSK 986
>NP_757366
          Length = 1332

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KILNEQTAK 9
           K+L+E+T+K
Sbjct: 978 KLLDEKTSK 986
>NP_733751
          Length = 4911

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 1989 VVSEQTAK 1996
>NP_001128128
          Length = 452

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KILNEQ 6
           KILNEQ
Sbjct: 210 KILNEQ 215
>NP_997287
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   KILNEQ 6
           KILNEQ
Sbjct: 184 KILNEQ 189
>XP_006721187
          Length = 266

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  ILNEQTAK 9
          +LN +TAK
Sbjct: 39 VLNHETAK 46
>XP_005254403
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KILNEQTAK 9
           K+L+E+T+K
Sbjct: 277 KLLDEKTSK 285
>XP_005254402
          Length = 721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KILNEQTAK 9
           K+L+E+T+K
Sbjct: 368 KLLDEKTSK 376
>XP_005254401
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1   KILNEQTAK 9
           K+L+E+T+K
Sbjct: 368 KLLDEKTSK 376
>XP_005254400
          Length = 1378

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    KILNEQTAK 9
            K+L+E+T+K
Sbjct: 1025 KLLDEKTSK 1033
>XP_005254399
          Length = 1379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 9/9 (100%)

Query: 1    KILNEQTAK 9
            K+L+E+T+K
Sbjct: 1025 KLLDEKTSK 1033
>XP_006716142
          Length = 4927

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>XP_005250088
          Length = 4928

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>XP_006716141
          Length = 4959

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>XP_005250085
          Length = 4979

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>XP_006716140
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>XP_005250084
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>XP_005250083
          Length = 4982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2005 VVSEQTAK 2012
>XP_005250082
          Length = 4983

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    ILNEQTAK 9
            +++EQTAK
Sbjct: 2006 VVSEQTAK 2013
>NP_001035820
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KILNEQTA 8
           KIL E+TA
Sbjct: 139 KILEEKTA 146
>NP_001035822
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KILNEQTA 8
          KIL E+TA
Sbjct: 67 KILEEKTA 74
>NP_001035816
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KILNEQTA 8
           KIL E+TA
Sbjct: 148 KILEEKTA 155
>NP_001035823
          Length = 145

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KILNEQTA 8
          KIL E+TA
Sbjct: 67 KILEEKTA 74
>NP_001035818
          Length = 269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KILNEQTA 8
           KIL E+TA
Sbjct: 139 KILEEKTA 146
>NP_056420
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KILNEQTA 8
           KIL E+TA
Sbjct: 148 KILEEKTA 155
>NP_001035817
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KILNEQTA 8
           KIL E+TA
Sbjct: 139 KILEEKTA 146
>NP_001278017
          Length = 2912

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KILNEQT 7
            K++NE+T
Sbjct: 1239 KVINEET 1245
>NP_114157
          Length = 2873

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KILNEQT 7
            K++NE+T
Sbjct: 1200 KVINEET 1206
>NP_001258579
          Length = 280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KILNEQ 6
          K+LNEQ
Sbjct: 10 KVLNEQ 15
>NP_071906
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KILNEQ 6
           K+LNEQ
Sbjct: 122 KVLNEQ 127
>NP_001276018
          Length = 1123

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 986 LNETTAK 992
>NP_079048
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    LNEQTAK 9
            LNE TAK
Sbjct: 1005 LNETTAK 1011
>NP_001276019
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    LNEQTAK 9
            LNE TAK
Sbjct: 1005 LNETTAK 1011
>NP_001276017
          Length = 1142

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3    LNEQTAK 9
            LNE TAK
Sbjct: 1005 LNETTAK 1011
>NP_001276020
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 645 LNETTAK 651
>NP_001127905
          Length = 232

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KILNEQ 6
           K+LNEQ
Sbjct: 122 KVLNEQ 127
>NP_055592
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KILNEQTAK 9
           KI+NE+ A+
Sbjct: 101 KIINERVAE 109
>NP_001127904
          Length = 243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KILNEQ 6
           K+LNEQ
Sbjct: 122 KVLNEQ 127
>XP_006726580
          Length = 116

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KILNEQTA 8
          KIL E+TA
Sbjct: 67 KILEEKTA 74
>XP_006726579
          Length = 139

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KILNEQTA 8
          KIL E+TA
Sbjct: 67 KILEEKTA 74
>XP_006723474
          Length = 2737

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KILNEQT 7
            K++NE+T
Sbjct: 1064 KVINEET 1070
>XP_005259362
          Length = 2855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KILNEQT 7
            K++NE+T
Sbjct: 1182 KVINEET 1188
>XP_005270372
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KILNEQTA 8
          KIL E+TA
Sbjct: 67 KILEEKTA 74
>XP_006717817
          Length = 206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KILNEQTA 8
           KIL E+TA
Sbjct: 148 KILEEKTA 155
>XP_005277709
          Length = 339

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  KILNEQTA 8
          KIL E+TA
Sbjct: 67 KILEEKTA 74
>XP_005265449
          Length = 392

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KILNEQ 6
           K+LNEQ
Sbjct: 122 KVLNEQ 127
>XP_005273417
          Length = 1487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KILNEQTAK 9
           KI+NE+ A+
Sbjct: 101 KIINERVAE 109
>XP_005271279
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 645 LNETTAK 651
>XP_005271277
          Length = 951

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 814 LNETTAK 820
>XP_005271276
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 930 LNETTAK 936
>XP_005271275
          Length = 1067

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 930 LNETTAK 936
>XP_005271273
          Length = 1130

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   LNEQTAK 9
           LNE TAK
Sbjct: 993 LNETTAK 999
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.300    0.116    0.271 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 391,081
Number of extensions: 642
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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