Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     299
NP_001091680                                                           20     299
NP_001091679                                                           20     299
XP_006713048                                                           20     299
XP_006713047                                                           20     299
XP_006713046                                                           20     299
XP_005264943                                                           20     299
NP_054735                                                              18    1482
NP_000375                                                              17    2528
NP_060764                                                              16    5631
NP_940905                                                              16    5631
NP_001274748                                                           16    5631
NP_001274749                                                           16    5631
NP_065873                                                              16    5631
NP_064450                                                              16    5631
NP_001258932                                                           16    5631
XP_006717257                                                           16    5631
XP_006717256                                                           16    5631
XP_005273257                                                           16    5631
XP_006711358                                                           16    5631
XP_006711357                                                           16    5631
NP_075252                                                              16    7355
NP_998812                                                              16    7355
NP_002002                                                              16    7355
NP_056163                                                              16    7355
XP_005265895                                                           16    7355
XP_005265894                                                           16    7355
XP_005263969                                                           16    7355
XP_005263968                                                           16    7355
XP_005263967                                                           16    7355
XP_005263966                                                           16    7355
NP_931045                                                              15    9605
NP_001137499                                                           15    9605
NP_055249                                                              15    9605
NP_001137500                                                           15    9605
NP_001137498                                                           15    9605
NP_031375                                                              15    9605
NP_001431                                                              15    9605
XP_006717822                                                           15    9605
XP_006717119                                                           15    9605
XP_005266123                                                           15    9605
XP_006716365                                                           15    9605
XP_005249598                                                           15    9605
XP_005249596                                                           15    9605
XP_005249594                                                           15    9605
XP_005249593                                                           15    9605
>NP_001895
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 133 KHAVVNLIN 141
>NP_001091680
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 133 KHAVVNLIN 141
>NP_001091679
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 133 KHAVVNLIN 141
>XP_006713048
          Length = 720

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 133 KHAVVNLIN 141
>XP_006713047
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 126 KHAVVNLIN 134
>XP_006713046
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 126 KHAVVNLIN 134
>XP_005264943
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           KH VVNLIN
Sbjct: 133 KHAVVNLIN 141
>NP_054735
          Length = 587

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KHVVVNLIN 9
           K V++NLIN
Sbjct: 301 KQVIINLIN 309
>NP_000375
          Length = 4563

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KHVVVNLI 8
            KH V+NLI
Sbjct: 2318 KHFVINLI 2325
>NP_060764
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KHVVVNL 7
           KH+VVN+
Sbjct: 339 KHLVVNI 345
>NP_940905
          Length = 1135

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 174 KHALENMIN 182
>NP_001274748
          Length = 1111

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 174 KHALENMIN 182
>NP_001274749
          Length = 1068

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 174 KHALENMIN 182
>NP_065873
          Length = 1235

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 246 KHALENMIN 254
>NP_064450
          Length = 1722

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KHVVVNLIN 9
            +H VVNL N
Sbjct: 1383 QHAVVNLDN 1391
>NP_001258932
          Length = 1211

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 198 KHALENMIN 206
>XP_006717257
          Length = 1083

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KHVVVNLIN 9
          KH + N+IN
Sbjct: 73 KHALENMIN 81
>XP_006717256
          Length = 1172

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 162 KHALENMIN 170
>XP_005273257
          Length = 1726

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    KHVVVNLIN 9
            +H VVNL N
Sbjct: 1387 QHAVVNLDN 1395
>XP_006711358
          Length = 1118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 174 KHALENMIN 182
>XP_006711357
          Length = 1142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHVVVNLIN 9
           KH + N+IN
Sbjct: 174 KHALENMIN 182
>NP_075252
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KHVVVN 6
           KH+V+N
Sbjct: 285 KHIVIN 290
>NP_998812
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KHVVVN 6
           KH+V+N
Sbjct: 285 KHIVIN 290
>NP_002002
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KHVVVN 6
           KH+V+N
Sbjct: 285 KHIVIN 290
>NP_056163
          Length = 1883

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KHVVVNLI 8
           +H+++NLI
Sbjct: 922 RHLILNLI 929
>XP_005265895
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KHVVVN 6
           KH+V+N
Sbjct: 285 KHIVIN 290
>XP_005265894
          Length = 834

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KHVVVN 6
           KH+V+N
Sbjct: 317 KHIVIN 322
>XP_005263969
          Length = 1844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KHVVVNLI 8
           +H+++NLI
Sbjct: 883 RHLILNLI 890
>XP_005263968
          Length = 1861

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KHVVVNLI 8
           +H+++NLI
Sbjct: 900 RHLILNLI 907
>XP_005263967
          Length = 1899

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KHVVVNLI 8
           +H+++NLI
Sbjct: 939 RHLILNLI 946
>XP_005263966
          Length = 1900

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   KHVVVNLI 8
           +H+++NLI
Sbjct: 939 RHLILNLI 946
>NP_931045
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  KHVVVNLIN 9
          KH++VN  N
Sbjct: 28 KHLLVNHFN 36
>NP_001137499
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VVNLIN 9
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_055249
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VVNLIN 9
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_001137500
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VVNLIN 9
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_001137498
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VVNLIN 9
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_031375
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KHVVVNLIN 9
           +H+V+NL++
Sbjct: 804 QHLVLNLLD 812
>NP_001431
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   HVVVNL 7
           HV++NL
Sbjct: 273 HVIINL 278
>XP_006717822
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   KHVVVNLI 8
           KH +VN++
Sbjct: 780 KHQIVNVV 787
>XP_006717119
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VVNLIN 9
          VVNLIN
Sbjct: 45 VVNLIN 50
>XP_005266123
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  VVNLIN 9
          VVNLIN
Sbjct: 45 VVNLIN 50
>XP_006716365
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   HVVVNL 7
           HV++NL
Sbjct: 273 HVIINL 278
>XP_005249598
          Length = 1027

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KHVVVNLIN 9
           +H+V+NL++
Sbjct: 757 QHLVLNLLD 765
>XP_005249596
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KHVVVNLIN 9
           +H+V+NL++
Sbjct: 770 QHLVLNLLD 778
>XP_005249594
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KHVVVNLIN 9
           +H+V+NL++
Sbjct: 770 QHLVLNLLD 778
>XP_005249593
          Length = 1074

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   KHVVVNLIN 9
           +H+V+NL++
Sbjct: 804 QHLVLNLLD 812
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.141    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 455,465
Number of extensions: 825
Number of successful extensions: 46
Number of sequences better than 10000.0: 46
Number of HSP's gapped: 46
Number of HSP's successfully gapped: 46
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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