Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001013433                                                           18    1135
NP_060785                                                              18    1135
NP_361014                                                              18    1135
NP_542401                                                              17    2528
NP_001006608                                                           17    4312
NP_955372                                                              17    4312
NP_055649                                                              17    4312
XP_005275724                                                           17    4312
XP_005275722                                                           17    4312
XP_005275721                                                           17    4312
XP_006725345                                                           17    4312
XP_006725344                                                           17    4312
XP_005275719                                                           17    4312
XP_006725343                                                           17    4312
XP_006725342                                                           17    4312
XP_005275717                                                           17    4312
XP_005275716                                                           17    4312
XP_005257941                                                           17    4312
XP_005257940                                                           17    4312
XP_006722274                                                           17    4312
XP_006722273                                                           17    4312
XP_005257939                                                           17    4312
XP_006722272                                                           17    4312
XP_005257937                                                           17    4312
XP_005257936                                                           17    4312
XP_005257935                                                           17    4312
XP_006722271                                                           17    4312
XP_005272075                                                           17    4312
NP_057688                                                              17    4312
NP_006460                                                              16    5631
NP_065961                                                              16    5631
NP_001158137                                                           16    5631
XP_006716134                                                           16    5631
XP_005244900                                                           16    5631
NP_060606                                                              16    7355
NP_055317                                                              16    7355
NP_001193775                                                           16    7355
NP_001240658                                                           16    7355
NP_001240657                                                           16    7355
NP_001240656                                                           16    7355
NP_001240659                                                           16    7355
NP_001240662                                                           16    7355
NP_001240661                                                           16    7355
NP_067647                                                              16    7355
NP_036265                                                              16    7355
NP_001276962                                                           16    7355
NP_057212                                                              16    7355
NP_008835                                                              15    9605
NP_001075109                                                           15    9605
NP_001165375                                                           15    9605
NP_055518                                                              15    9605
NP_001017408                                                           15    9605
NP_065132                                                              15    9605
NP_056436                                                              15    9605
NP_722576                                                              15    9605
XP_005262424                                                           15    9605
XP_005261392                                                           15    9605
XP_005276812                                                           15    9605
XP_006713491                                                           15    9605
XP_005276811                                                           15    9605
XP_006713490                                                           15    9605
XP_005276810                                                           15    9605
XP_005276809                                                           15    9605
XP_006713489                                                           15    9605
XP_005276808                                                           15    9605
NP_689639                                                              15    9605
NP_689631                                                              15    9605
>NP_001013433
          Length = 589

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHQSAVTRL 9
           KHQSAVT L
Sbjct: 504 KHQSAVTCL 512
>NP_060785
          Length = 627

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHQSAVTRL 9
           KHQSAVT L
Sbjct: 542 KHQSAVTCL 550
>NP_361014
          Length = 707

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   KHQSAVTRL 9
           KHQSAVT L
Sbjct: 622 KHQSAVTCL 630
>NP_542401
          Length = 324

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KHQSAVTRL 9
           KH S++TRL
Sbjct: 272 KHGSSITRL 280
>NP_001006608
          Length = 1700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>NP_955372
          Length = 1634

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>NP_055649
          Length = 1700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005275724
          Length = 894

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005275722
          Length = 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005275721
          Length = 1018

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006725345
          Length = 1600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006725344
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 341 HQEATTRL 348
>XP_005275719
          Length = 1625

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006725343
          Length = 1635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006725342
          Length = 1651

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005275717
          Length = 1665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005275716
          Length = 1676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005257941
          Length = 969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005257940
          Length = 1018

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006722274
          Length = 1576

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006722273
          Length = 1600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005257939
          Length = 1606

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 341 HQEATTRL 348
>XP_006722272
          Length = 1635

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005257937
          Length = 1651

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005257936
          Length = 1665

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005257935
          Length = 1676

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_006722271
          Length = 1700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           HQ A TRL
Sbjct: 435 HQEATTRL 442
>XP_005272075
          Length = 1561

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HQSAVTRL 9
           HQ ++TRL
Sbjct: 221 HQDSITRL 228
>NP_057688
          Length = 1761

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HQSAVTRL 9
           HQ ++TRL
Sbjct: 221 HQDSITRL 228
>NP_006460
          Length = 642

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHQSAVTRL 9
           +HQSAV  L
Sbjct: 502 RHQSAVCEL 510
>NP_065961
          Length = 1934

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HQSAVTRL 9
           H+SAVT L
Sbjct: 762 HESAVTAL 769
>NP_001158137
          Length = 1950

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HQSAVTRL 9
           H+SAVT L
Sbjct: 762 HESAVTAL 769
>XP_006716134
          Length = 1847

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HQSAVTRL 9
           H+SAVT L
Sbjct: 686 HESAVTAL 693
>XP_005244900
          Length = 424

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHQSAVTRL 9
           +HQSAV  L
Sbjct: 284 RHQSAVCEL 292
>NP_060606
          Length = 3477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KHQSAVTRL 9
            KH   VTRL
Sbjct: 3274 KHLEVVTRL 3282
>NP_055317
          Length = 504

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HQSAVTRL 9
           H+SAVT L
Sbjct: 305 HESAVTGL 312
>NP_001193775
          Length = 1892

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    KHQSAVTRL 9
            KH   VTRL
Sbjct: 1689 KHLEVVTRL 1697
>NP_001240658
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 559 HQSAIT 564
>NP_001240657
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 574 HQSAIT 579
>NP_001240656
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 634 HQSAIT 639
>NP_001240659
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 476 HQSAIT 481
>NP_001240662
          Length = 601

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 451 HQSAIT 456
>NP_001240661
          Length = 625

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 475 HQSAIT 480
>NP_067647
          Length = 757

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HQSAVT 7
           HQSA+T
Sbjct: 607 HQSAIT 612
>NP_036265
          Length = 871

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KHQSAVT 7
           KH SAVT
Sbjct: 317 KHPSAVT 323
>NP_001276962
          Length = 726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KHQSAVT 7
           KH SAVT
Sbjct: 317 KHPSAVT 323
>NP_057212
          Length = 874

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   KHQSAVT 7
           KH SAVT
Sbjct: 317 KHPSAVT 323
>NP_008835
          Length = 4128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HQSAVTRL 9
            HQS +T+L
Sbjct: 3122 HQSRLTKL 3129
>NP_001075109
          Length = 4097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    HQSAVTRL 9
            HQS +T+L
Sbjct: 3122 HQSRLTKL 3129
>NP_001165375
          Length = 1506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1133 HNSAITHL 1140
>NP_055518
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>NP_001017408
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHQSAVTRL 9
           KH+ AVT L
Sbjct: 340 KHKEAVTIL 348
>NP_065132
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHQSAVTRL 9
           KH+ AVT L
Sbjct: 348 KHKEAVTIL 356
>NP_056436
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  KHQSAVTRL 9
          +HQ  +TR+
Sbjct: 55 RHQKDITRI 63
>NP_722576
          Length = 3080

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KHQSAVTR 8
           K QSAVT+
Sbjct: 392 KSQSAVTK 399
>XP_005262424
          Length = 2875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KHQSAVTR 8
           K QSAVT+
Sbjct: 187 KSQSAVTK 194
>XP_005261392
          Length = 217

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  KHQSAVTR 8
          KH SAV R
Sbjct: 43 KHHSAVFR 50
>XP_005276812
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>XP_006713491
          Length = 1425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1052 HNSAITHL 1059
>XP_005276811
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>XP_006713490
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>XP_005276810
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>XP_005276809
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>XP_006713489
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>XP_005276808
          Length = 1507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HQSAVTRL 9
            H SA+T L
Sbjct: 1134 HNSAITHL 1141
>NP_689639
          Length = 386

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   KHQSAVTR 8
           KH SAV R
Sbjct: 239 KHHSAVFR 246
>NP_689631
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HQSAVTRL 9
           H SAVT L
Sbjct: 269 HDSAVTSL 276
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.117    0.306 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 405,379
Number of extensions: 493
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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