Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results 
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done




                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000236                                                              22     134
NP_001120972                                                           22     134
XP_006716054                                                           22     134
XP_006716053                                                           22     134
XP_006716052                                                           22     134
XP_006716051                                                           22     134
NP_056998                                                              17    3301
NP_005042                                                              17    3301
NP_001259002                                                           17    3301
XP_005255403                                                           17    3301
NP_620448                                                              17    4312
NP_002744                                                              17    4312
XP_006714335                                                           17    4312
XP_006714334                                                           17    4312
XP_006714332                                                           17    4312
XP_005263192                                                           17    4312
XP_005263188                                                           17    4312
XP_005263187                                                           17    4312
XP_005263186                                                           17    4312
XP_006714330                                                           17    4312
NP_859526                                                              16    5631
NP_002543                                                              16    5631
NP_001177810                                                           16    5631
NP_001177808                                                           16    5631
NP_001177811                                                           16    5631
NP_859525                                                              16    5631
XP_006712619                                                           16    5631
NP_001019832                                                           16    7355
NP_001278309                                                           16    7355
NP_065816                                                              16    7355
NP_075390                                                              16    7355
NP_075389                                                              16    7355
NP_060101                                                              16    7355
XP_006725017                                                           16    7355
XP_006711144                                                           16    7355
XP_006710573                                                           16    7355
XP_006710572                                                           16    7355
XP_006710571                                                           16    7355
XP_006710570                                                           16    7355
XP_006710569                                                           16    7355
XP_006710568                                                           16    7355
XP_006710567                                                           16    7355
XP_006710566                                                           16    7355
XP_005245859                                                           16    7355
NP_003174                                                              15    9605
NP_065681                                                              15    9605
NP_066124                                                              15    9605
NP_004125                                                              15    9605
XP_006717999                                                           15    9605



>NP_000236
          Length = 1390

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHFNMSLII 9
           KHFNMS+II
Sbjct: 632 KHFNMSIII 640





>NP_001120972
          Length = 1408

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHFNMSLII 9
           KHFNMS+II
Sbjct: 632 KHFNMSIII 640





>XP_006716054
          Length = 960

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHFNMSLII 9
           KHFNMS+II
Sbjct: 202 KHFNMSIII 210





>XP_006716053
          Length = 960

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHFNMSLII 9
           KHFNMS+II
Sbjct: 202 KHFNMSIII 210





>XP_006716052
          Length = 1409

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHFNMSLII 9
           KHFNMS+II
Sbjct: 651 KHFNMSIII 659





>XP_006716051
          Length = 1427

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHFNMSLII 9
           KHFNMS+II
Sbjct: 651 KHFNMSIII 659





>NP_056998
          Length = 958

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KHFNMSLI 8
           +HFN SL+
Sbjct: 296 RHFNTSLV 303





>NP_005042
          Length = 775

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HFNMSLII 9
           HFNM L++
Sbjct: 143 HFNMGLLM 150





>NP_001259002
          Length = 764

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HFNMSLII 9
           HFNM L++
Sbjct: 132 HFNMGLLM 139





>XP_005255403
          Length = 744

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHFNMSLI 8
          +HFN SL+
Sbjct: 82 RHFNTSLV 89





>NP_620448
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>NP_002744
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_006714335
          Length = 245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_006714334
          Length = 245

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_006714332
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_005263192
          Length = 422

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_005263188
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_005263187
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_005263186
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>XP_006714330
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHFNMS 6
          KH+NMS
Sbjct: 35 KHYNMS 40





>NP_859526
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 268 KHFNIS 273





>NP_002543
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 268 KHFNIS 273





>NP_001177810
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 184 KHFNIS 189





>NP_001177808
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 268 KHFNIS 273





>NP_001177811
          Length = 362

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 194 KHFNIS 199





>NP_859525
          Length = 436

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 268 KHFNIS 273





>XP_006712619
          Length = 352

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KHFN+S
Sbjct: 184 KHFNIS 189





>NP_001019832
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KHFNMSLII 9
           KH N+S ++
Sbjct: 323 KHLNLSYVL 331





>NP_001278309
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KHFNMSLII 9
           KH N+S ++
Sbjct: 323 KHLNLSYVL 331





>NP_065816
          Length = 5183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>NP_075390
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KHFNMSLII 9
           KH N+S ++
Sbjct: 323 KHLNLSYVL 331





>NP_075389
          Length = 474

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   KHFNMSLII 9
           KH N+S ++
Sbjct: 323 KHLNLSYVL 331





>NP_060101
          Length = 1712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HFNMSLII 9
            HFN  L+I
Sbjct: 1057 HFNNKLVI 1064





>XP_006725017
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  KHFNMSLII 9
          KH N+S ++
Sbjct: 78 KHLNLSYVL 86





>XP_006711144
          Length = 229

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  KHFNMSLII 9
          KH N+S ++
Sbjct: 78 KHLNLSYVL 86





>XP_006710573
          Length = 5177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710572
          Length = 5188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710571
          Length = 5194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710570
          Length = 5195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710569
          Length = 5212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710568
          Length = 5221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710567
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_006710566
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>XP_005245859
          Length = 5223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HFNMSLI 8
           HFN SL+
Sbjct: 712 HFNHSLV 718





>NP_003174
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   KHFNMS 6
           KH+NM+
Sbjct: 296 KHYNMA 301





>NP_065681
          Length = 1072

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HFNMSLI 8
           HFN+S++
Sbjct: 392 HFNVSVL 398





>NP_066124
          Length = 1114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HFNMSLI 8
           HFN+S++
Sbjct: 392 HFNVSVL 398





>NP_004125
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1   KHFNMSL 7
           KH NM L
Sbjct: 340 KHLNMKL 346





>XP_006717999
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   HFNMSLI 8
           HFN+S++
Sbjct: 485 HFNVSVL 491





  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.341    0.146    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 439,725
Number of extensions: 463
Number of successful extensions: 49
Number of sequences better than 10000.0: 49
Number of HSP's gapped: 49
Number of HSP's successfully gapped: 49
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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