Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
NP_060552                                                              17    2528
NP_001154180                                                           17    2528
NP_001245283                                                           17    3301
NP_004238                                                              17    3301
NP_001245282                                                           17    3301
NP_001136077                                                           17    3301
NP_055289                                                              17    3301
NP_932348                                                              17    4312
XP_005256402                                                           17    4312
XP_006722342                                                           17    4312
NP_001155244                                                           16    7355
NP_000860                                                              16    7355
NP_116265                                                              16    7355
NP_998786                                                              16    7355
NP_001276026                                                           16    7355
NP_001139447                                                           16    7355
NP_003975                                                              16    7355
NP_004362                                                              16    7355
NP_001091868                                                           16    7355
XP_006722228                                                           16    7355
NP_783297                                                              15    9605
NP_003248                                                              15    9605
NP_000254                                                              15    9605
NP_001254489                                                           15    9605
NP_001243839                                                           15    9605
NP_004808                                                              15    9605
NP_001164101                                                           15    9605
NP_001165402                                                           15    9605
NP_001165401                                                           15    9605
NP_055724                                                              15    9605
NP_963923                                                              15    9605
NP_071407                                                              15    9605
NP_001163886                                                           15    9605
NP_060506                                                              15    9605
NP_004719                                                              15    9605
NP_003562                                                              15    9605
NP_001276863                                                           15    9605
NP_001254490                                                           15    9605
XP_006725623                                                           15    9605
XP_006725622                                                           15    9605
XP_006725621                                                           15    9605
XP_006725620                                                           15    9605
XP_006725619                                                           15    9605
XP_006725618                                                           15    9605
XP_006725617                                                           15    9605
XP_006725616                                                           15    9605
XP_006722787                                                           15    9605
XP_005259596                                                           15    9605
XP_005254678                                                           15    9605
XP_006720724                                                           15    9605
XP_005254677                                                           15    9605
XP_005254676                                                           15    9605
XP_005254675                                                           15    9605
XP_006720723                                                           15    9605
XP_005254674                                                           15    9605
XP_005254673                                                           15    9605
XP_006720250                                                           15    9605
XP_006718005                                                           15    9605
XP_006718004                                                           15    9605
XP_006718003                                                           15    9605
XP_005252372                                                           15    9605
XP_006717387                                                           15    9605
XP_005252371                                                           15    9605
XP_005252370                                                           15    9605
XP_005252369                                                           15    9605
XP_005252368                                                           15    9605
XP_005275746                                                           15    9605
XP_003403671                                                           15    9605
XP_006710003                                                           15    9605
NP_001163885                                                           15    9605
NP_001163887                                                           15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHAVLDRMA 9
           K+AVLDRMA
Sbjct: 607 KNAVLDRMA 615
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHAVLDRMA 9
           K+AVLDRMA
Sbjct: 607 KNAVLDRMA 615
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHAVLDRMA 9
           K+AVLDRMA
Sbjct: 607 KNAVLDRMA 615
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHAVLDRMA 9
           K+AVLDRMA
Sbjct: 607 KNAVLDRMA 615
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   KHAVLDRMA 9
           K+AVLDRMA
Sbjct: 607 KNAVLDRMA 615
>NP_060552
          Length = 1133

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    KHAVLDRM 8
            KH VLD+M
Sbjct: 1013 KHMVLDKM 1020
>NP_001154180
          Length = 1075

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KHAVLDRM 8
           KH VLD+M
Sbjct: 955 KHMVLDKM 962
>NP_001245283
          Length = 962

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           KHAV +R+A
Sbjct: 234 KHAVQERLA 242
>NP_004238
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           KHAV +R+A
Sbjct: 244 KHAVQERLA 252
>NP_001245282
          Length = 972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           KHAV +R+A
Sbjct: 244 KHAVQERLA 252
>NP_001136077
          Length = 937

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           KHAV +R+A
Sbjct: 209 KHAVQERLA 217
>NP_055289
          Length = 455

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HAVLDRMA 9
           H VLDR+A
Sbjct: 376 HTVLDRIA 383
>NP_932348
          Length = 915

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHAVLDRMA 9
           KH  LDR+A
Sbjct: 284 KHEELDRLA 292
>XP_005256402
          Length = 751

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHAVLDRMA 9
           KH  LDR+A
Sbjct: 284 KHEELDRLA 292
>XP_006722342
          Length = 762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHAVLDRMA 9
           KH  LDR+A
Sbjct: 295 KHEELDRLA 303
>NP_001155244
          Length = 463

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           +H VL+R+A
Sbjct: 329 RHLVLERIA 337
>NP_000860
          Length = 484

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           +H VL+R+A
Sbjct: 350 RHLVLERIA 358
>NP_116265
          Length = 538

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HAVLDRM 8
           HA LDR+
Sbjct: 208 HAALDRL 214
>NP_998786
          Length = 516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KHAVLDRMA 9
           +H VL+R+A
Sbjct: 382 RHLVLERIA 390
>NP_001276026
          Length = 369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HAVLDRM 8
           HA LDR+
Sbjct: 208 HAALDRL 214
>NP_001139447
          Length = 641

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAVLDRM 8
           HAVLD++
Sbjct: 202 HAVLDQL 208
>NP_003975
          Length = 592

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAVLDRM 8
           HAVLD++
Sbjct: 153 HAVLDQL 159
>NP_004362
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KHAVLDRM 8
           + AVLDRM
Sbjct: 425 RFAVLDRM 432
>NP_001091868
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   KHAVLDRM 8
           + AVLDRM
Sbjct: 425 RFAVLDRM 432
>XP_006722228
          Length = 549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAVLDRM 8
           HAVLD++
Sbjct: 109 HAVLDQL 115
>NP_783297
          Length = 1668

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 702 KHALLD 707
>NP_003248
          Length = 1748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 702 KHALLD 707
>NP_000254
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   KHAVLDRM 8
           +H VLD+M
Sbjct: 226 QHRVLDQM 233
>NP_001254489
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 672 KHALLD 677
>NP_001243839
          Length = 715

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KHAVLDRM 8
           KH VLD +
Sbjct: 266 KHVVLDEV 273
>NP_004808
          Length = 1190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 787 KHALLD 792
>NP_001164101
          Length = 993

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 787 KHALLD 792
>NP_001165402
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 837 HAMLDR 842
>NP_001165401
          Length = 1381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 837 HAMLDR 842
>NP_055724
          Length = 365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KH+VLD
Sbjct: 276 KHSVLD 281
>NP_963923
          Length = 1043

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 787 KHALLD 792
>NP_071407
          Length = 3354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 837 HAMLDR 842
>NP_001163886
          Length = 1157

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 791 KHALLD 796
>NP_060506
          Length = 2078

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   HAVLDRMA 9
           H++L+R+A
Sbjct: 858 HSILERIA 865
>NP_004719
          Length = 783

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   KHAVLDRM 8
           KH VLD +
Sbjct: 334 KHVVLDEV 341
>NP_003562
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 406 HALLDR 411
>NP_001276863
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 646 HALLDR 651
>NP_001254490
          Length = 928

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 681 KHALLD 686
>XP_006725623
          Length = 1766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 700 KHALLD 705
>XP_006725622
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 706 KHALLD 711
>XP_006725621
          Length = 1735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_006725620
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_006725619
          Length = 1768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 702 KHALLD 707
>XP_006725618
          Length = 1772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 706 KHALLD 711
>XP_006725617
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_006725616
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_006722787
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 672 KHALLD 677
>XP_005259596
          Length = 938

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 691 KHALLD 696
>XP_005254678
          Length = 1766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 700 KHALLD 705
>XP_006720724
          Length = 1692

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 706 KHALLD 711
>XP_005254677
          Length = 1735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_005254676
          Length = 1755

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_005254675
          Length = 1768

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 702 KHALLD 707
>XP_006720723
          Length = 1772

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 706 KHALLD 711
>XP_005254674
          Length = 1815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_005254673
          Length = 1835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 769 KHALLD 774
>XP_006720250
          Length = 2077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   HAVLDRMA 9
           H++L+R+A
Sbjct: 857 HSILERIA 864
>XP_006718005
          Length = 3397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 880 HAMLDR 885
>XP_006718004
          Length = 3399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 882 HAMLDR 887
>XP_006718003
          Length = 3419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 902 HAMLDR 907
>XP_005252372
          Length = 1102

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 846 KHALLD 851
>XP_006717387
          Length = 1188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 785 KHALLD 790
>XP_005252371
          Length = 1194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 791 KHALLD 796
>XP_005252370
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 846 KHALLD 851
>XP_005252369
          Length = 1213

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 810 KHALLD 815
>XP_005252368
          Length = 1249

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 846 KHALLD 851
>XP_005275746
          Length = 3352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 835 HAMLDR 840
>XP_003403671
          Length = 3354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 837 HAMLDR 842
>XP_006710003
          Length = 3374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAVLDR 7
           HA+LDR
Sbjct: 857 HAMLDR 862
>NP_001163885
          Length = 1020

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 764 KHALLD 769
>NP_001163887
          Length = 1221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAVLD 6
           KHA+LD
Sbjct: 818 KHALLD 823
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.131    0.370 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 476,881
Number of extensions: 852
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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