Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_078951                                                              17    2528
NP_001231639                                                           17    2528
NP_002047                                                              17    2528
NP_006690                                                              17    3301
XP_006710365                                                           17    3301
NP_004949                                                              17    4312
NP_001171559                                                           17    4312
NP_003889                                                              17    4312
NP_001261                                                              17    4312
XP_005267257                                                           17    4312
XP_005267256                                                           17    4312
XP_005267255                                                           17    4312
XP_006715655                                                           17    4312
XP_005267254                                                           17    4312
XP_006715654                                                           17    4312
XP_005271924                                                           17    4312
XP_005271923                                                           17    4312
XP_005263496                                                           17    4312
XP_005263495                                                           17    4312
NP_036381                                                              16    5631
NP_065768                                                              16    5631
NP_116178                                                              16    5631
XP_006724654                                                           16    5631
XP_006724653                                                           16    5631
XP_005251138                                                           16    5631
XP_005264286                                                           16    5631
NP_899234                                                              16    5631
NP_001127845                                                           16    7355
NP_036361                                                              16    7355
NP_001159734                                                           16    7355
NP_690876                                                              16    7355
NP_001159733                                                           16    7355
NP_001159735                                                           16    7355
XP_006719836                                                           16    7355
XP_006719835                                                           16    7355
XP_006719834                                                           16    7355
XP_005266340                                                           16    7355
XP_005269693                                                           16    7355
XP_005269692                                                           16    7355
XP_005269691                                                           16    7355
XP_005269690                                                           16    7355
XP_005269689                                                           16    7355
NP_005111                                                              15    9605
NP_060626                                                              15    9605
NP_056193                                                              15    9605
NP_997244                                                              15    9605
NP_009049                                                              15    9605
NP_001189404                                                           15    9605
NP_001874                                                              15    9605
NP_001189411                                                           15    9605
NP_061836                                                              15    9605
NP_001189410                                                           15    9605
NP_060959                                                              15    9605
NP_663630                                                              15    9605
NP_387505                                                              15    9605
XP_005262376                                                           15    9605
XP_005262374                                                           15    9605
XP_005261051                                                           15    9605
XP_006715714                                                           15    9605
XP_006714558                                                           15    9605
XP_005245393                                                           15    9605
XP_006711515                                                           15    9605
XP_006711514                                                           15    9605
XP_006711513                                                           15    9605
>NP_078951
          Length = 1186

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  KHAIKKT 7
          KH+IKKT
Sbjct: 45 KHSIKKT 51
>NP_001231639
          Length = 699

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HAIKKTAG 9
           H IK+TAG
Sbjct: 310 HRIKRTAG 317
>NP_002047
          Length = 681

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   HAIKKTAG 9
           H IK+TAG
Sbjct: 292 HRIKRTAG 299
>NP_006690
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHAIKKTAG 9
           KH IKK+ G
Sbjct: 432 KHLIKKSRG 440
>XP_006710365
          Length = 637

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   KHAIKKTAG 9
           KH IKK+ G
Sbjct: 432 KHLIKKSRG 440
>NP_004949
          Length = 2549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KHAIKKTAG 9
            +HA+  TAG
Sbjct: 2288 EHAVNNTAG 2296
>NP_001171559
          Length = 1259

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 573 KHPFDKTAG 581
>NP_003889
          Length = 1496

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 810 KHPFDKTAG 818
>NP_001261
          Length = 1710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KHAIKK 6
            KHAIKK
Sbjct: 1498 KHAIKK 1503
>XP_005267257
          Length = 909

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 223 KHPFDKTAG 231
>XP_005267256
          Length = 1113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 427 KHPFDKTAG 435
>XP_005267255
          Length = 1165

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 479 KHPFDKTAG 487
>XP_006715655
          Length = 1288

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 810 KHPFDKTAG 818
>XP_005267254
          Length = 1443

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 757 KHPFDKTAG 765
>XP_006715654
          Length = 1495

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH   KTAG
Sbjct: 809 KHPFDKTAG 817
>XP_005271924
          Length = 1710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KHAIKK 6
            KHAIKK
Sbjct: 1498 KHAIKK 1503
>XP_005271923
          Length = 1798

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    KHAIKK 6
            KHAIKK
Sbjct: 1586 KHAIKK 1591
>XP_005263496
          Length = 2322

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KHAIKKTAG 9
            +HA+  TAG
Sbjct: 2061 EHAVNNTAG 2069
>XP_005263495
          Length = 2549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    KHAIKKTAG 9
            +HA+  TAG
Sbjct: 2288 EHAVNNTAG 2296
>NP_036381
          Length = 205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH +KK  G
Sbjct: 187 KHTVKKRIG 195
>NP_065768
          Length = 1493

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1    KHAIKKT 7
            KHA+KK+
Sbjct: 1028 KHALKKS 1034
>NP_116178
          Length = 1025

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHAIKKTAG 9
           KHA+ +T G
Sbjct: 274 KHALLRTGG 282
>XP_006724654
          Length = 1335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KHAIKKT 7
           KHA+KK+
Sbjct: 870 KHALKKS 876
>XP_006724653
          Length = 1377

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KHAIKKT 7
           KHA+KK+
Sbjct: 912 KHALKKS 918
>XP_005251138
          Length = 1037

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   KHAIKKTAG 9
           KHA+ +T G
Sbjct: 286 KHALLRTGG 294
>XP_005264286
          Length = 118

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   KHAIKKTAG 9
           KH +KK  G
Sbjct: 100 KHTVKKRIG 108
>NP_899234
          Length = 1134

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   KHAIKKTAG 9
           +H+ +KTAG
Sbjct: 911 RHSKRKTAG 919
>NP_001127845
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>NP_036361
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>NP_001159734
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>NP_690876
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>NP_001159733
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>NP_001159735
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_006719836
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_006719835
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_006719834
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_005266340
          Length = 278

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  KHAIKKTA 8
          KH ++KTA
Sbjct: 26 KHILQKTA 33
>XP_005269693
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269692
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269691
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269690
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>XP_005269689
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  KHAIKK 6
          KHA+KK
Sbjct: 21 KHALKK 26
>NP_005111
          Length = 2177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAIKK 6
           +HAIKK
Sbjct: 768 RHAIKK 773
>NP_060626
          Length = 4363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KHAIKKT 7
            KH+++KT
Sbjct: 2085 KHSLRKT 2091
>NP_056193
          Length = 4388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KHAIKKT 7
            KH+++KT
Sbjct: 2085 KHSLRKT 2091
>NP_997244
          Length = 3169

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1    KHAIKKT 7
            KH+++KT
Sbjct: 1285 KHSVEKT 1291
>NP_009049
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KHAIKKT 7
           +HAI+KT
Sbjct: 954 QHAIEKT 960
>NP_001189404
          Length = 438

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAIKKTA 8
           H+IK+TA
Sbjct: 430 HSIKQTA 436
>NP_001874
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAIKKTA 8
           H+IK+TA
Sbjct: 403 HSIKQTA 409
>NP_001189411
          Length = 410

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAIKKTA 8
           H+IK+TA
Sbjct: 402 HSIKQTA 408
>NP_061836
          Length = 2320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HAIKKTAG 9
            HA  +TAG
Sbjct: 1767 HACNRTAG 1774
>NP_001189410
          Length = 397

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAIKKTA 8
           H+IK+TA
Sbjct: 389 HSIKQTA 395
>NP_060959
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KHAIKKTAG 9
            KH +KK  G
Sbjct: 2314 KHKLKKRRG 2322
>NP_663630
          Length = 402

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   HAIKKT 7
           HAIK+T
Sbjct: 224 HAIKRT 229
>NP_387505
          Length = 2269

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HAIKKTAG 9
            HA  +TAG
Sbjct: 1767 HACNRTAG 1774
>XP_005262376
          Length = 2155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAIKK 6
           +HAIKK
Sbjct: 768 RHAIKK 773
>XP_005262374
          Length = 2180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   KHAIKK 6
           +HAIKK
Sbjct: 768 RHAIKK 773
>XP_005261051
          Length = 2242

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    HAIKKTAG 9
            HA  +TAG
Sbjct: 1689 HACNRTAG 1696
>XP_006715714
          Length = 411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   HAIKKTA 8
           H+IK+TA
Sbjct: 403 HSIKQTA 409
>XP_006714558
          Length = 2612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   KHAIKKT 7
           +HAI+KT
Sbjct: 469 QHAIEKT 475
>XP_005245393
          Length = 2663

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KHAIKKTAG 9
            KH +KK  G
Sbjct: 2314 KHKLKKRRG 2322
>XP_006711515
          Length = 2904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KHAIKKTAG 9
            KH +KK  G
Sbjct: 2254 KHKLKKRRG 2262
>XP_006711514
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KHAIKKTAG 9
            KH +KK  G
Sbjct: 2314 KHKLKKRRG 2322
>XP_006711513
          Length = 2964

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    KHAIKKTAG 9
            KH +KK  G
Sbjct: 2314 KHKLKKRRG 2322
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.121    0.331 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 490,358
Number of extensions: 928
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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